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Inherited retinal degenerative diseases (IRDs) are a group of rare diseases that lead to a progressive loss of photoreceptor cells and, ultimately, blindness. The overactivation of cGMP-dependent protein kinase G (PKG), one of the key effectors of cGMP-signaling, was previously found to be involved in photoreceptor cell death and was studied in murine IRD models to elucidate the pathophysiology of

Extraction of vitamin D, including its hydroxylated and esterified metabolites, from soft tissues such as the liver is challenging due to the lipophilic character of matrix and analytes that are expected in very low concentration levels. In this study, we aimed at the optimization of two-step extraction using solid–liquid extraction as the first step, followed by solid-phase extraction. Various so

Purpose: The aim was to investigate the use of multiple small VOIs for kidney dosimetry in [177Lu]Lu-DOTA-TATE therapy. Method: The study was based on patient and simulated SPECT images in anthropomorphic geometries. Images were reconstructed using two reconstruction programs (local LundaDose and commercial Hermia) using OS-EM with and without resolution recovery (RR). Five small VOIs were placed

Food Safety 4.0 is a term derived from Industry 4.0 that focuses on all aspects of food safety management based on cyber-physical systems. The premise of Food Safety 4.0 is that real-time information and the interconnectivity of things, complemented by novel technologies, will revolutionize the way food safety is managed. There is enormous potential in terms of advancing product traceability, dete

In normal colon tissue, oestrogen receptor alpha (ERα) is expressed at low levels, while oestrogen receptor beta (ERβ) is considered the dominant subtype. However, in colon carcinomas, the ERα/β ratio is often increased, an observation that prompted us to further investigate ERα’s role in colorectal cancer (CRC). Here, we assessed ERα nuclear expression in 351 CRC patients. Among them, 119 exhibit

Fat-soluble vitamin D is an essential bioactive compound important for human health. Insufficient vitamin D levels can result not only in bone disease but also in other disorders, such as cancer, metabolic disorders, and diseases related to poor immune function. The current methods commonly used for vitamin D analysis are often applied to determine the levels of the most abundant metabolite in pla

Program om Hawaiis historia från sent 1700-tal till tidigt med 1900-tal med fokus på Liliʻuokalani, ögruppens sista drottning.

AimsThe pathophysiology of orthostatic hypotension (OH), a common clinical condition, associated with adverse outcomes, is incompletely understood. We examined the relationship between OH and circulating endostatin, an endogenous angiogenesis inhibitor with antitumor effects proposed to be involved in blood pressure (BP) regulation.MethodsWe compared endostatin levels in 146 patients with OH and 1

Cu2AgBiI6 (CABI) is a promising perovskite-inspired absorber for solar cells due to its direct band gap and high absorption coefficient. However, the nonradiative recombination caused by the high extrinsic trap density limits the performance of CABI-based solar cells. In this work, we employ halide engineering by doping bromide anions (Br–) in CABI thin films, in turn significantly improving t

Photoelectrochemical water splitting and CO2 reduction provide an attractive route to produce solar fuels while reducing the level of CO2 emissions. Metal halide perovskites (MHPs) have been extensively studied for this purpose in recent years due to their suitable optoelectronic properties. In this review, we survey the recent achievements in the field. After a brief introduction to photoelectroc

This study focuses on children’s voices as they were presented in Swedish newspapers during the COVID-19 pandemic. It explores the ways in which journalists featured children’s experiences of everyday life during a time of crisis. A descriptive, thematic text analysis of 83 articles resulted in four prominent themes: children’s voices as a mouthpiece for or against school closure, children as cocr

Multidrug-resistant Pseudomonas aeruginosa is an increasing clinical problem worldwide. The aim of this study was to describe the first outbreak of a Verona integron-borne metallo-ß-lactamase (VIM)-2-producing P. aeruginosa strain in Sweden and its expansion in the region. A cluster of multidrug-resistant P. aeruginosa appeared at two neighbouring hospitals in 2006. The isolates were characterized

This book aims to provide practical aspects of, and an introduction to, the applications of various technological advancement tools, such as AI, machine learning to design, big data, cloud computing, and IoT, to model, characterize, optimize, forecast, and do performance prediction of renewable energy exploitation. It further discusses new avenues for energy sources such as hydrogen energy generat

Den 22 januari 2024 meddelade Högsta förvaltningsdomstolen dom i ännu ett mål avseende de riktade ränteavdragsbegränsningsreglerna. Skatterättsnämnden hade i ett förhandsbesked tidigare slagit fast att även 24 kap. 19 § första stycket IL var oförenlig med etableringsfriheten, vilket nu även bekräftas av Högsta förvaltningsdomstolen med stöd av argumentationen i Lexel-målet. Detta avgörande innebär

DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids. The process of DNA phase separation induced by positively charged species is often called DNA condensation. Generally, it refers to either intramolecular DNA compaction (coil-globule transition) or intermolecular D

This paper deals with the prediction of train-induced building vibrations by using a numerical framework. The framework is based on a sub-structure approach, where a sequence of different models are used. The free-field ground vibrations and the track receptance are calculated using 2.5D technique where the railway track is represented by finite elements that couple to a dynamic stiffness of the u

Humanitarian logistics (HL) is a relatively new research area that requires clear boundaries and a defined foundational perspective. Recent disasters have shown that the scope of HL is expanding, as in cases of cash-based interventions, outsourcing to commercial companies, and stronger involvement of local communities. These changes imply the importance of scrutinizing the old definitions of HL an