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Måttlig hypotermi efter perinatal asfyxi reducerar mortaliteten och risken för överlevnad med svårt handikapp, visar två randomiserade, kontrollerade studier. Fler studier pågår och förväntas bli publicerade inom de närmaste åren. Den publicerade studien visar dock att det endast är barn med måttlig hjärnskada som har effekt av hypotermi. Hypotermi efter perinatal asfyxi kan ännu inte rekommenderaTwo randomised controlled trials evaluating intervention with moderate hypothermia after perinatal asphyxia will probably be published this year. The first study, evaluating head cooling with a "cool cap" is already published, and preliminary data from the other study evaluating body cooling earlier have been presented. Both studies indicate that moderate hypothermia, initiated within 6 h after bi

Material and methods: In all, 237 consecutive patients with a perforated peptic ulcer admitted from 1974-1992 and 125 consecutive patients with an oesophageal perforation admitted from 1970-2006 to Lund University hospital were studied retrospectively. Prognostic factors were evaluated using the Cox proportional hazards model. All cases of gastro-duodenal ulcer perforations diagnosed in Sweden fr

Objectives: To evaluate the effects of cariporide on all-cause mortality or myocardial infarction at 36 days in patients at risk,of myocardial necrosis after coronary artery bypass graft surgery. Methods: In the coronary artery bypass graft cohort of the GUARD During Ischemia Against Necrosis trial, patients greater than or equal to 18 years who required urgent coronary artery bypass graft, repeat

The overall aim of this thesis was to provide a representative estimate of the potential impacts of climate change and increased atmospheric CO2 concentrations on Swedish forest ecosystems and the key ecosystem services they provide. In order to achieve this task, fi rst LPJ-GUESS, a process-based regional ecosystem modelling framework, was applied to explore how possible shifts in climatic zones

Popular Abstract in Swedish Denna avhandling beskriver olika metoder att förbättra motorstabilitet och minska skadliga avgasutsläpp från naturgasmotorer. Gasflöden inuti cylindern mättes med laserdiagnostik, även cylindertryck och avgassammansättning mättes. Sex olika förbränningsrum utvärderades med ovan angivna metoder. Ett högturbulent (brinner snabbt) förbränningsrum visade sig fungera bäst meThe objective of this thesis was to find ways to improve combustion and reduce emissions from supercharged natural gas engines. In-cylinder flow measurements were made with laser doppler velocimetry, LDV, heat release was calculated from cylinder pressures and emissions were measured at various locations. The original combustion chamber was a low turbulence-generating geometry, resulting in an ove

OBJECTIVE--To explore associations between exposure to asbestos cement dust and radiographic findings in lung parenchyma and pleura. METHODS--Radiographs from 174 blue collar workers and 29 white collar workers from an asbestos cement plant formed one part of the study. Progression of small opacities was further studied in those 124 blue collar workers, for whom two radiographs taken after the end

The aim of the study reported here was to investigate changes in the digestive enzyme content in the pancreas after food and secretagogue stimulation. Rats from which food had been withheld overnight were either fed (between 6 and 8 a.m.) or not before euthanasia and pancreatic excision (at 8 a.m.: 21 not fed and 21 fed) and at 4 (12 p.m.: six not fed and six fed) and 8 h later (4 p.m.: six not fe

An unprejudiced revision of the genus Pilosella (Asteraceae) in the Nordic countries has been attempted. A completely new system for the taxonomy of these mostly facultative apomicts is presented. It is argued that all existing systems are inappropriate in the light of the complicated, and largely unknown, reproductive biology of these taxa. Previous systems have either treated these taxa as oblig

Background. Genital prolapse is a common and handicapping form of pelvic floor dysfunction. To explain its genesis as a result of endopelvic connective tissue weakness, the collagen state was analyzed in women with and without genital prolapse. Methods. Punch biopsies from the paraurethral ligaments were obtained during the operation from 22 women undergoing surgery for genital prolapse. As contro

Objective: To assess the absorption of dietary selenium in humans, especially of milk selenium. Design: 1-day meal studies in subjects with ileostomy. Setting: Hospital outpatient clinics. Subjects: Three subjects in the pilot study and nine subjects in the main study ( eight men/four women). Intervention: Different beverages, 1 l/day, were given in addition to basal diets ( soft drink, 1 week; lo

The planning and construction of a facility can affect several interests. Positive effects are, for instance, better communications, better housing and a higher standard of living. However, construction projects inevitably bring varying degrees of deterioration and change at the local level, not least at the construction site. Representatives of these interests are referred to as the project's sta

Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote,

A haemagglutinating monoclonal anti-LebL antibody has been obtained from a mouse-mouse hybridoma after immunization with the Leb-active oligosaccharide lacto-N-difucohexaose I, coupled to edestin. Of 13 other antibodies obtained, one was able to agglutinate enzyme-treated erythrocytes of all ABO groups and three more were considered to be anti-LebH haemagglutinins. The remaining nine antibodies di

Background: BRCA1 is a tumour suppressor with pleiotropic actions. Germline mutations in BRCA1 are responsible for a large proportion of breast - ovarian cancer families. Several missense variants have been identified throughout the gene but because of lack of information about their impact on the function of BRCA1, predictive testing is not always informative. Classification of missense variants

Src homology 2 (SH2) and SH3 domains are abundant protein and peptide binding modules in signalling molecules. Certain SH2 and SH3 domains have been shown to form functional and physical interactions. The structural basis of dimer formation was studied by docking three dimensional structures of the domains and by analysing structural and functional properties of the dimers. The experimentally veri