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The complement system plays an important role in varying types of disease, ranging from inflammatory and autoimmune disorders to immune deficiency states. In addition, new settings have emerged where complement analysis is of interest to monitor complement-directed therapy and aid identification of transplant complications. Therefore, it is critical that clinical laboratories offer optimized and t
Massively parallel sequencing (MPS) methods are increasingly applied in forensic casework. However, adequate validation guidelines are lacking. In this work, we describe our in-house validation of the ForenSeq DNA Signature Prep Kit (Verogen) for analysis of ancestry- and phenotype-informative SNPs. We also discuss in-house validation of MPS assays in general terms. When validating the SNP assay,
The need to integrate climate change adaptation (CCA) considerations into disaster risk management (DRM) systems is widely recognised. However, successful integration, and thus the implementation of integrated planning measures, is difficult in practice. To understand and reduce the problems encountered, it is important to investigate systemic challenges. These challenges are rooted in the interac
We present a new algorithm for solving the LPN problem. The algorithm has a similar form as some previous methods, but includes a new key step that makes use of approximations of random words to a nearest codeword in a linear code. It outperforms previous methods for many parameter choices. In particular, we can now solve the (512,18) LPN instance with complexity less than 2 80 operations in expec
An important challenge when coupling two different time dependent problems is to increase parallelization in time. We suggest a multirate Neumann-Neumann waveform relaxation algorithm to solve two heterogeneous coupled heat equations. In order to fix the mismatch produced by the multirate feature at the space-time interface a linear interpolation is constructed. The heat equations are discretized
Understanding the etiology and meaning of behavioral symptomatology in the context of neurologic disease, and choosing the most effective intervention is a vexing task. This introduction summarizes the history of our understanding of the relationship between behavioral symptoms and primary neurologic conditions, and considers the ways in which both psychiatric and neurologic disorders occurring si
We study two-dimensional eigenvalue ensembles close to certain types of singular points in the interior of the droplet. We prove existence of a microscopic density which quickly approaches the equilibrium density, as the distance from the singularity increases beyond the microscopic scale. This kind of asymptotic is used to analyze normal matrix models in [3]. In addition, we obtain here asymptoti
Age-related macular degeneration (AMD) is the most common cause of visual impairment in the developed world. A number of patients experience complex lifelike visual experiences—Charles Bonnet syndrome (CBS). In this systematic review, our aim was to provide an overview of the CBS literature in relation to AMD, to determine the prevalence of CBS in patients with AMD and to provide an overview of as
Direct neuronal reprogramming can be achieved using different approaches: by expressing neuronal transcription factors or microRNAs; and by knocking down neuronal repressive elements. However, there still exists a high variability in terms of the quality and maturity of the induced neurons obtained, depending on the reprogramming strategy employed. Here, we evaluate different long-term culture con
A dominating set of a graph G is a set D⊆ VG such that every vertex in VG- D is adjacent to at least one vertex in D, and the domination number γ(G) of G is the minimum cardinality of a dominating set of G. A set C⊆ VG is a covering set of G if every edge of G has at least one vertex in C. The covering number β(G) of G is the minimum cardinality of a covering set of G. The set of connected graphs
The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability coefficients. In this pape
There is a growing interest in organized self-help housing (OSHH) from both authoriti es and Non Governmental Organizati ons (NGOs) working in the housing sector due to the magnitude of housing problems in developing countries and the challenge of achieving sustainable humansett lements. This paper focuses on the experiences of two NGOs, FUPROVI in Costa Rica and SADEL in Sweden, in facilitati ng
Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were rep
The global anti-doping effort in sport is based upon perceptions of the system as desirable, proper and appropriate and thus considered legitimate. The legitimacy of the anti-doping system has earlier been studied bottom-up, based on the views of athletes. In order to gain greater understanding of legitimation processes, it is also important to study legitimation strategies top-down, used by decis
Objective: To describe the incidence of incorrect computerized ECG interpretations of atrial fibrillation or atrial flutter in a Swedish primary care population, the rate of correction of computer misinterpretations, and the consequences of misdiagnosis. Design: Retrospective expert re-analysis of ECGs with a computer-suggested diagnosis of atrial fibrillation or atrial flutter. Setting: Primary h
