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The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-cells in vitro. However, in some dasatinib-treated leukemia patients, clonal lymphocytosis with large granular lymphocyte (LGL) morphology develops, and this is associated with enhanced therapeutic responses. To elucidate the mechanistic basis for this paradoxical observation, we conducted detailed phenotypi

This paper critically investigates the impact and meaning of managerialism in a pharmaceutical firm by exploring its shaky basis. Managers' explanations of the failure in research leading to new products showed considerable variety. This reflects the absence of any shared understanding of research inefficiencies and difficulties to determine the roots of the problems. Despite this people blame bad

The @b-delayed charged particle emission from 11Li has been studied with emphasis on the three-body n@a6He and five-body 2@a3n channels from the 10.59 and 18.15 MeV states in 11Be. Monte Carlo simulations using an R-matrix formalism lead to the conclusion that the AHe resonance states play a significant role in the break-up of these states. The results exclude an earlier assumption of a phase-spac

There exists an increasing demand for cost and time efficient cutting tests for describing the performance of different combinations of cutting tools and workpiece materials in the cutting process both in industry and academia. Cutting tools are expected to withstand the heat and the pressure developed during the machining of difficult to machine materials such as Ti6Al4V. This article introduces

Using data recorded in 2011 with the ATLAS detector at the Large Hadron Collider, a search for evidence of extra spatial dimensions has been performed through an analysis of the diphoton final state. The analysis uses data corresponding to an integrated luminosity of 2.12 fb(-1) of root s = 7 TeV proton-proton collisions. The diphoton invariant mass (m(gamma gamma)) spectrum is observed to be in g

In this paper we study the energy loss of jets in the Quark Gluon Plasma via the nuclear modification factor R-AA for unidentified particles at high p(T) (greater than or similar to 10 GeV/c) in and out of the reaction plane of the collision. We argue that at such a high p(T) there are no genuine flow effects and, assuming that the energy loss is only sensitive to initial characteristics such as t

Recently the account of free will proposed by Harry Frankfurt has come under attack. It has been argued that Frankfurt’s notion of wholeheartedness is in conflict with prevalent intuitions about free will and should be abandoned. I will argue that empirical data from choice blindness experiments can vindicate Frankfurt’s notion of wholeheartedness. The choice blindness phenomenon exposes that indi

The text-critical problem in the very beginning of the Gospel of Mark is both crucial and much debated. The main question is whether the phrase ‘Son of God’ was accidentally omitted from an original or added by some scribes in order to expand the divine name or the title of the book. The disputed words are enclosed in square brackets in UBS4 and NA27 but omitted in the recent SBLGNT edition. Where

A laser method to suppress background interferences in pump - probe measurements is presented and demonstrated. The method is based on structured illumination, where the intensity profile of the pump beam is spatially modulated to make its induced photofragment signal distinguishable from that created solely by the probe beam. A spatial lock-in algorithm is then applied on the acquired data, extra

CAM2028, a vehicle that forms a bioadhesive lipid barrier when applied to the oral mucosa, was developed as a carrier system for local delivery of benzydamine, an NSAID used for pain relief in oral mucositis. This trial compared the analgesic effect of CAM2028 plus benzydamine (CAM2028-benzydamine) with unmedicated CAM2028 (CAM2028-control) for the treatment of oral mucositis in patients with head