Filtyp
Monoclonal gammopathy of undetermined significance (MGUS) is a necessary precursor condition to multiple myeloma (MM). Given the role of autophagy in modulating MM risk, we investigated whether genetic variation in autophagy-related genes influences susceptibility to MGUS. We analyzed the association of 34,042 common autophagy-related single nucleotide polymorphisms (SNPs) with MGUS across six ind
Habitat loss and nutrient enrichment are major drivers of plant species declines. However, local extinction risks vary widely and are shaped by life-history trait syndromes. Genomic life-history traits, which are simple, stable and widely available, offer a promising yet underexplored approach to improving extinction risk assessments and informing conservation efforts. Using a spatial comparison a
Effective and locally supported river restoration requires attention to the social dimensions of rivers. This paper examines local perceptions of hydropower and restoration in the river Rönne å, an early case under Sweden’s National Plan for Modern Environmental Conditions for Hydropower. A mixed-methods approach, including a questionnaire and qualitative interviews, explores how inhabitants relat
The article consists of six core sections. Firstly, it argues for examining the language, origin, use and meaning of key concepts when seeking to understand historical perspectives. Secondly, is a concrete investigation of three concepts related to the French Revolution: ‘historical monument’, ‘vandalism’, and ‘heritage’. Thirdly, it describes how ‘historical monument’ was replaced by ‘heritage’ aThe article consists of six core sections. Firstly, it argues for examining the language, origin, use and meaning of key concepts when seeking to understand historical perspectives. Secondly, is a concrete investigation of three concepts related to the French Revolution: ‘historical monument’, ‘vandalism’, and ‘heritage’. Thirdly, it describes how ‘historical monument’ was replaced by ‘heritage’ a
Blink characteristics such as duration, amplitude, and eyelid velocity are widely used indicators of cognitive and physiological states. While early magnetic search coil studies suggested that vertical eye orientation relative to the head influences blink measurements, subsequent research has largely ignored this factor. No studies have investigated whether vertical eye orientation effects replica
Dermatan sulfate epimerase 1 (DS-epi1) is a key enzyme in the biosynthesis of the glycosaminoglycan chondroitin sulfate/dermatan sulfate, catalyzing the conversion of glucuronic acid to iduronic acid at the polymer level. Chondroitin sulfate/dermatan sulfate chains are found on at least 32 proteoglycans, many of which are implicated in human diseases and syndromes, as well as in both malignant and
A search for heavy pseudo-scalar (A) and scalar (H) Higgs bosons decaying into a top-quark pair (tt¯) has been performed with 140 fb−1 of proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a centre-of-mass energy of s = 13 TeV. Interference effects between the signal process and Standard Model (SM) tt¯ production are taken into account. Final states with
Properties of the underlying-event in pp interactions are investigated primarily via the strange hadrons KS0, Λ and Λ¯, as reconstructed using the ATLAS detector at the LHC in minimum-bias pp collision data at s=13 TeV. The hadrons are reconstructed via the identification of the displaced two-particle vertices corresponding to the decay modes, Λ→π-p and Λ¯→π+p¯. These are used in the construction
The striving for a sustainable energy system entails an increasing use of renewable energy. Since several renewable energy sources are non-dispatchable (e.g., wind and solar), this development brings challenges in terms of the balance between energy supply and demand. As a result, there is a growing need for demand-side flexibility.The building stock has been highlighted as a promising resource of
A search for a new heavy boson produced via gluon-fusion in the four-lepton channel with missing transverse momentum or jets is performed. The search uses proton-proton collision data equivalent to an integrated luminosity of 139 fb−1 at a centre-of-mass energy of 13 TeV collected by the ATLAS detector between 2015 and 2018 at the Large Hadron Collider. This study explores the decays of heavy boso
Olof Palme förknippas ofta med sin utrikespolitik. Men på hemmaplan fattades beslut som fick stora ekonomiska konsekvenser. Fem av dem formade Sverige – och rymmer tydliga lärdomar, skriver Lars Jonung.
Toxin-antitoxin-chaperone (TAC) systems are three-part gene clusters encoding a toxin, antitoxin, and specialized SecB-like chaperone (SecB TA) with emerging roles in phage defense. To identify and classify SecB homologs and associated TACs across bacteria, we surveyed the full RefSeq database. Phylogenetic and gene neighborhood analyses reveal three major SecB subfamilies: two housekeeping group
INTRODUCTION: Amyloid-induced tauopathy drives clinical decline in Alzheimer's disease (AD). Because age and sex shape tau trajectories, defining patient-centered amyloid thresholds for tauopathy onset could facilitate pre-tauopathy AD identification and aid treatment decisions and prognosis. METHODS: By including two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI, n = 301]; and 18F-AV
Contributing to global urban history, planning theory and the geography of ideas, this article discusses the travels of Henri Lefebvre’s The Right to the City in the wake of May 1968, in France. That year, under the direction of Mario González and Max Baquero, a small team including the Italian architect Vittorio Garatti, French planner Jean-Pierre Garnier and Spanish architect Eusebio Azcue, at t
