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Glial cell-line derived neurotrophic factor (GDNF) has demonstrated robust effects on dopamine (DA) neuron function and survival. A post-translational processing model of the human GDNF proprotein theorizes the formation of smaller, amidated peptide(s) from the proregion that exhibit neurobiological function, including an 11-amino-acid peptide named dopamine neuron stimulating peptide-11 (DNSP-11)
This article presents a water balance equation for predicting leachate generation in municipal solid waste (MSW) landfills located in semi-arid areas, using the Akaider landfill in Jordan as an example. HYDRUS-2D/3D software was used to model the effect of co-disposal of wastewater into the landfill on the leachate production rates and for comparison with the results of the simulation of the propo
The ATLAS experiment at the LHC has measured the Higgs boson couplings and mass, and searched for invisible Higgs boson decays, using multiple production and decay channels with up to 4.7 fb(-1) of pp collision data at root S = 7 TeV and 20.3 fb(-1) at root s = 8 TeV. In the current study, the measured production and decay rates of the observed Higgs boson in the gamma gamma, ZZ, WW, Z gamma, bb,
Inconspicuous consumption, the habitual use of resources in daily routines, poses a challenge to sustainable consumption. For example, laundry is often the most environmentally demanding stage of clothing’s life cycle, consuming significant quantities of water, energy and chemicals. Laundry thus provides a prime example of inconspicuous consumption, from which to consider sustainability transition
A total of 308,036 women were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) study to evaluate the association between tobacco smoking and the risk of cervical intraepithelial neoplasia of grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). At baseline, participants completed a questionnaire and provided blood samples. During a mean fol
Helianthemum nummularium (L.) Mill. has two subspecies in southern Scandinavia, which differ in an indumentum character that is inherited as a Mendelian gene with two alleles. The dominant allele is the genetic basis for the key character of subsp. obscurum (absence of a dense felt of stellate hairs on the abaxial surface of the leaf), whereas the recessive allele is the genetic basis for the key
Electricity spot prices are characterized by sudden large movements, followed a few days later by an equally large movement in the opposite direction. These phenomena are called spikes (upward movements) and drops (downward movements). Recent research has suggested that the dynamics of the electricity spot prices can be accurately described by hidden Markov Regime Switching (MRS) models. Regime sw
Pollen and sediment stratigraphic analyses of a transect of core sequences are used to reconstruct Holocene lake-level changes in Lake Igelsjon, southern Sweden. The pattern of changes seen in the records is related to climatic/hydrological changes and agrees principally with the pattern characteristically found in lakes in southern Sweden. However, compared with an earlier study based on isotopic
OBJECTIVES: Rheumatoid arthritis (RA) is less common among men than women, and sex hormones have been suggested to play a part in the pathogenesis. Lower levels of testosterone have been demonstrated in men with RA, but it is not known if these changes precede the disease. METHODS: In a nested case-control study, using information and blood samples from a population-based health survey, we identif
High-throughput sequencing data generation demands the development of methods for interpreting the effects of genomic variants. Numerous computational methods have been developed to assess the impact of variations because experimental methods are unable to cope with both the speed and volume of data generation. To harness the strength of currently available predictors, the Pathogenic-or-Not-Pipeli
Genetically based adaptation and phenotypic plasticity represent important means of coping with natural or human-induced increases in soil acidity. In the present study, we examined the role of phenotypic plasticity in the grass Deschampsia cespitosa by testing for general and trait-specific responses to acid and aluminium (Al) stress. We sampled tussocks (genets) from sites in southern Sweden dif
The present study seeks to investigate the extent to which the Acceptance and Action Questionnaire (AAQ-II) is successful in discriminating between experiential avoidance/psychological flexibility on the one hand and the supposed outcomes in terms of psychological well-being of having this trait on the other. This was done using exploratory factor analysis on an item pool containing the AAQ-II ite
The nonessential process of peptidoglycan synthesis during Bacillus subtilis sporulation is one model to study bacterial cell wall biogenesis. SpoVD is a class B high-molecular weight penicillin-binding protein that is specific for sporulation. Strains lacking this protein produce spores without the peptidoglycan cortex layer and are heat-sensitive. The detailed functions of the four different pro
In this work we investigate nascent soot particles by analyzing laser-induced incandescence (LII) signals obtained in low-sooting premixed flames. The analysis covers two data sets obtained in separate experimental campaigns. The first data set was obtained in a previous work (Mouton et al., 2013) in methane/oxygen/nitrogen flames (equivalence ratio range 1.95 < Phi < 2.32) at 26.7 kPa, whereas th
Perfluoroalkyl acids (PFAAs) are a large group of chemicals which are highly persistent in both nature and humans. The use of the most prominent ones, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), was reduced in the early 21st century, and since then levels in human matrices have decreased. However, these two compounds have been exchanged by other PFAAs, for which time trends
We examined combined effects of biochar, arbuscular mycorrhizal (AM) fungi and salinity on plant growth and physiology to test whether and how biochar influences AM fungi mediated growth and nutrition enhancements, and whether and how biochar provides amelioration in salt stressed soils. We carried out a full three-factorial greenhouse experiment with Lactuca sativa; and a second study with a wide
Infectious etiologies have been hypothesized for Hodgkin and non-Hodgkin lymphoma (HL and NHL) in early life, but findings to date for specific lymphomas and periods of susceptibility are conflicting. We conducted the first national cohort study to examine whether season of birth, a proxy for infectious exposures in the first few months of life, is associated with HL or NHL in childhood through yo
BACKGROUND: Acute lymphoblastic leukaemia (ALL) patients treated with cranial radiotherapy (CRT) have an increased risk of GH deficiency (GHD). Little is known about insufficiencies of prolactin (PRL) and TSH, but also lactation failure has been reported in this population. OBJECTIVE: To study the long-term outcome of CRT on PRL and thyroid hormone levels in GHD ALL patients, and the prevalence of
Over the past years, massive progress has been made in the ability to collect large-scale gene expression data from a limited sample size. Combined with improvements in multiplex flow cytometry-based techniques, this has made it possible to isolate and characterize specific cellular subtypes within heterogeneous populations, with a great impact on our understanding of different biological processe
Oak moss absolute (Evernia prunastri extract) contains a large number of substances, among them the potent allergens atranol and chloroatranol. Since 2008, their content in oak moss absolute has been restricted by the International Fragrance Association to a maximum level of 100 ppm each.
