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Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve

Purpose: Violence against women is a major public health concern. Comparative research on outcomes across different service providers remains limited. Method: Women seeking support from social welfare units or women’s shelters were recruited from six organizations in Sweden. A pre–post design was applied, with structured interviews and questionnaires at baseline and 1-year follow-up. Fifty-one womViolence against women is a major public health concern. Comparative research on outcomes across different service providers remains limited. Method: Women seeking support from social welfare units or women's shelters were recruited from six organizations in Sweden. A pre–post design was applied, with structured interviews and questionnaires at baseline and 1-year follow-up. Fifty-one women partic

Neurofilament light chain (NfL) is a promising biomarker of axonal injury across acute and chronic neurodegeneration, which can improve drug discovery and disease monitoring models. Traditional in vivo animal models cannot fully mimic human pathophysiology of neurodegenerative diseases (NDDs), but in vitro models based on human cells solve this problem, reducing the time and cost of drug testing.

The article examines Starbucks as a global cultural symbol whose success varies sharply across contexts, contrasting its exceptional growth in South Korea with its near failure in Sweden. In Korea, Starbucks has thrived by pioneering localized marketing and spatial design strategies, enjoying unusual autonomy from headquarters and shaping new consumption patterns; however, recent controversies hav

INTRODUCTION: Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease-modifying treatments emerge. Speech-based digital biomarkers offer scalable options for remotely capturing speech-derived functional changes associated with early cognitive decline, but validation across real-world populations remains limited.METHODS: We evaluated the speech biomarker for cogni

A detailed understanding of excited-state evolution is critical to realizing the full potential of abundant-metal coordination complex photosensitizers. Here, we show how wide-band optical transient absorption spectroscopy (oTA) can delineate the complete energy relaxation pathway of the photoexcited state of Fe(ii) polypyridyl complexes supported by benzannulated diarylamido ligands. By covering

BACKGROUND: Weight-related bias, stigma, and discrimination significantly affect quality of life and health in persons with obesity. Their influence on post-operative outcomes following metabolic surgery and bariatric remains underexplored.OBJECTIVES: This systematic review aimed to evaluate any impact of pre- and post-operative weight bias, stigma, and discrimination on post-metabolic and bariatr

Direct reprogramming offers a powerful approach to generate therapeutic cell types, but progress is limited by an incomplete understanding of transcription factor (TF) cooperativity. Here, we present a protocol for performing combinatorial TF screening to resolve reprogramming factor networks that drive cell identity. We describe steps for arrayed lentiviral production, transduction, and reprogram

In October 2023, storm Babet led to the most severe erosion in decades along the Swedish South coast. In this study we approach the affected coastal landscape as a coupled social-ecological system where environmental components (e.g. geology, bathymetry, waves) interact with social components (e.g. infrastructure, management, economic activities) to influence the outcome of an extreme event. We us

In communication and management research, coworker voice has been widely acknowledged as a central component for organizations’ long-term development and survival. With the increasing digitalization and need for flexibility, digital workplace meetings have become a common form of communication, demonstrating a new arena where coworker voice is expressed and shaped. Thus, the aim of this study is t

Time-resolved imaging of plasmonic near fields is well-established at visible wavelengths but remains largely unexplored in the short-wavelength infrared (SWIR) range. Here, we use time-resolved photoemission electron microscopy (TR-PEEM) to directly visualize ultrafast plasmon dynamics in silver nanowires driven by a few-cycle SWIR pulses. We observe strong electric-field enhancement localized at

Granulomas are organized immune aggregates of myeloid and lymphoid cells that arise when the host fails to eliminate persistent stimuli; however, their function remains paradoxical, by promoting both protection from systemic dissemination while also promoting a niche for microbial survival. Traditionally defined by histopathology and morphology, granulomas are now being revisited with high-through

Alzheimer's disease (AD) is marked by progressive cognitive decline, highlighting the importance of cognitive assessment in both clinical practice and research. This study investigates the temporal dynamics of cognitive decline and the differential sensitivity of cognitive measures across the AD spectrum. Cognitive measures, functional assessments, and amyloid-beta (Aβ) and tau positron emission t

Background: Metastasis-directed stereotactic body radiotherapy (MD-SBRT) has shown promise in retrospective and phase II studies for oligometastatic hormone-sensitive prostate cancer. However, prospective randomized phase III data—particularly in newly diagnosed cases and in combination with androgen deprivation therapy and next-generation androgen receptor pathway inhibitors—are limited. The METR