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The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina

Context. The analysis of precise Gaia DR3 astrometry in the LMC region has revealed asymmetric patterns in the bar quadrupole and the disc outskirts of the LMC in-plane velocity maps. Aims. We aim to quantify the asymmetries detected in the LMC radial and residual tangential velocity maps, and determine whether they are generated naturally due to the LMC’s interaction with the SMC. Methods. We ana

Brain metabolism is a fascinating and exciting research topic. Many new metabolic features of the brain continue to be unveiled and much remains to be discovered. To truly enable scientific progress, it is imperative that discoveries and theories are continually challenged through scholarly discussion. Here we address an earlier editorial by Bolaños et al. 2025 to underline the importance of embra

Objectives: To investigate the association between waiting time and outcomes in patients with upper tract urothelial carcinomas (UTUC). Patients and methods: We studied a population-based cohort of 858 patients in BladderBaSe 2.0 subjected to extirpative surgery for UTUC 2015–2019 in Sweden. Diagnostic waiting time (from referral to diagnosis, reference <1 week), treatment waiting time (from diagn

We investigate Chebyshev polynomials corresponding to Jacobi weights and determine monotonicity properties of their related Widom factors. This complements work by Bernstein from 1930 to 1931 where the asymptotical behavior of the related Chebyshev norms was established. As a part of the proof, we analyze a Bernstein-type inequality for Jacobi polynomials due to Chow et al. Our findings shed new l

Background: Development of secure attachment is crucial to establish and maintain healthy relationships with others throughout life. For parents with schizophrenia or bipolar disorder, challenged parental functioning may compromise the sensitive caregiving needed to establish secure child attachment. We aimed to examine pre-adolescent attachment, predictors related to caregiving, and middle childh

BACKGROUND AND OBJECTIVE: Prostate cancer (PC) and dementia may commonly co-occur; yet, prior evidence for bidirectional associations is inconsistent. This study aims to determine the associations between PC and dementia in large population-based studies, which may further inform clinical care. METHODS: To assess the dementia risk in men with PC, a national cohort study was conducted in 178 746 me

This chapter offers three complementary perspectives on Annals 2. Section one identifies deceit and deception as the major theme and analyzes how this theme is developed in and connects the various narratives of the book. Section two investigates an example of Tacitus’ historiographical mode that comes to the fore in Annals 2, namely the loosening of the annalistic structure for rhetorical effect,

The first WARA Robotics Mobile Manipulation Challenge, held in December 2024 at ABB Corporate Research in Vasteras, Sweden, addressed the automation of task-intensive and repetitive manual labor in laboratory environments - specifically the transport and cleaning of glassware. Designed in collaboration with AstraZeneca, the challenge invited academic teams to develop autonomous robotic systems cap

The retail industry is transforming at an unprecedented speed and scale with the advent of omnichannel strategies, thus leading to growing concerns about its environmental impact. The purpose of this paper is to identify the requirements that affect the possibilities of obtaining environmentally sustainable omnichannels and the strategies to be used by retailers and logistics service providers (LS

Structure-from-Motion (SfM) has become a ubiquitous tool for camera calibration and scene reconstruction with many downstream applications in computer vision and beyond. While the state-of-the-art SfM pipelines have reached a high level of maturity in well-textured and well-configured scenes over the last decades, they still fall short of robustly solving the SfM problem in challenging scenarios.

Digital innovation offers promising avenues for accessible, engaging, and user-friendly training solutions, crucial for promoting safety among manufacturing workers. However, optimizing these solutions demands a profound understanding of workers’ needs and preferences in interacting with these digital systems. The ongoing “DigiSafeMan” project aims to develop a prototype of a digital training tool

Patients with dementia experience a steady deterioration in cognitive function that increases mortality and impairments. Moreover, dementia is also anticipated to increase significantly in prevalence as the world's population ages, placing a strain on healthcare systems throughout the globe. Hence, early identification and prediction of dementia are essential due to timely treatments, enhanced pat

There has been great interest in the rationales for transformative innovation policies (TIP), including those following a mission-oriented logic. However, few studies have investigated how public administration can effectively implement TIP. To study this, we first identify from existing literature four TIP governance tasks (creating legitimacy and leadership, coordination across levels/instrument

Predicting probiotic strain properties that translate into beneficial effects in the host is challenging and could be considered the holy grail in developing new probiotics. One approach is to selectively evolve well-studied probiotic strains known to elicit beneficial effects in clinical studies. In this study, Limosilactobacillus reuteri DSM 17938, among the world's most studied probiotic strain

Purpose: This investigation was designed to examine the effects of self-monitored training combined with the use of delayed auditory feedback (DAF), on the accuracy of articulation in acquired apraxia of speech (AOS). Background: The increased number of stroke survivors leads to higher societal costs when it comes to e.g., rehabilitation. Speech and language deficits post stroke can be diminished

The current paper focuses on the conceptual design and numerical analysis of a four-stage centrifugal pump for the fuel system of a turbofan engine with liquid hydrogen as fuel. Liquid hydrogen is challenging at high pressures due to its special fluid properties. The design condition for the pump is set at take-off, to raise the pressure of liquid hydrogen from 6 bars at the outlet of a low-pressu

Context. Hot Jupiters are giant planets subject to intense stellar radiation. The physical and chemical properties of their atmosphere make them the most amenable targets for atmospheric characterization. Aims. In this paper we analyze the photometry collected during the secondary eclipses of the hot Jupiter WASP-3 b by CHEOPS, TESS, and Spitzer. Our aim is to characterize the atmosphere of the pl

With increasing climate-induced stresses and ageing infrastructure worldwide, integrating sustainability into infrastructure management is essential. Structural Health Monitoring (SHM) systems provide valuable insights for assessing and maintaining the safety and integrity of ageing structures, but their implementation entails significant costs. Resources allocated to SHM could alternatively suppo