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Background: Fragrance allergens are a leading cause of contact allergy (CA). Linalool, common in cosmetics and household products, forms sensitising hydroperoxides (Lin-OOH) upon air exposure. Lin-OOH is linked to a high prevalence (3.9%–11.7%) of positive patch test results, but often gives rise to doubtful or irritant reactions. Objectives: To reassess patch test concentrations of Lin-OOH, deter

Electrospinning is a versatile technique for manufacturing micro-nano diameter fibers and has been used extensively for tissue engineering in vivo and advanced cell culture in vitro. Standard means of seeding cells onto such substrates typically offer no control over cell distribution, yielding dispersed, heterogeneous and low concentrations of cells. In this article, we investigate the viability

Background: Severe COVID-19 frequently involves multi-organ dysfunction, including acute kidney injury (AKI), which affects up to 85% of critically ill patients. While both direct viral infection and systemic effects are implicated, the role of renal microthrombosis remains poorly defined in COVID-19 and AKI. Angiopoietin-2, a pro-inflammatory cytokine, and cleaved thrombomodulin is elevated in pl

High-energy hadronic collisions generate environments characterized by temperatures above 100 MeV (refs. 1,2), about 100,000 times hotter than the centre of the Sun. At present, it is therefore unclear how light (anti)nuclei with mass number A of a few units, such as the deuteron, 3He or 4He, each bound by only a few MeV, can emerge from these collisions3,4. Here, the ALICE Collaboration reports t

Ultrarelativistic heavy-ion collisions produce a state of hot and dense strongly interacting QCD matter called quark-gluon plasma (QGP). On an event-by-event basis, the volume of the QGP in ultracentral collisions is mostly constant, while its total entropy can vary significantly due to quantum fluctuations, leading to variations in the temperature of the system. Exploiting this unique feature of

The intense photon fluxes from relativistic nuclei provide an opportunity to study photonuclear interactions in ultraperipheral collisions. In particular, it allows for the investigations of excited, light-flavour vector mesons. The measurement of coherently photoproduced π+π−π+π− final states in ultraperipheral Pb–Pb collisions at sNN=5.02 TeV is presented for the first time. The cross section, d

Correlations among conserved quantum numbers, such as the net-electric charge, the net-baryon, and the net-strangeness in heavy-ion collisions, are crucial for exploring the QCD phase diagram. In this paper, these correlations are investigated using net-proton number (as a proxy for the net-baryon), net-kaon number (for the net-strangeness), and net-charged particle number in Pb-Pb collisions at =

Interfaces between magnetic and non-magnetic materials play a crucial role in various magnetic heterostructures. The emergence of 2D van der Waals (vdW) magnets has introduced new opportunities for exploring proximity effects in vdW heterostructures. While the influence of magnetic layers on nearby non-magnetic materials has been widely studied, it remains unclear whether non-magnetic substrates c

Heavy-flavor quarks produced in proton-proton (pp) collisions provide a unique opportunity to investigate the evolution of quark-initiated parton showers from initial hard scatterings to final-state hadrons. By examining jets that contain heavy-flavor hadrons, this study explores the effects of both perturbative and nonperturbative QCD on jet formation and structure. The angular differences betwee

Introduction: HIV guidelines recommend switching from a three-drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long-term outcomes of adults with HIV RNA <50 copies/ml who switched to DTG+3TC or a guideline-recommended 3DR between July 2019 and May 2023 in routine clinical c

The pathophysiology underlying various manifestations of cerebral small-vessel disease (cSVD) remains poorly understood. Using high-throughput proteomics, we identified common and distinct proteomic signatures of white matter lesions (WMLs), microbleeds, infarcts and their subtypes, measured in 1,670 living patients. Across all cSVD manifestations, markers of extracellular matrix dysregulation and

Light chain monoclonal gammopathy of undetermined significance (LC-MGUS) is an asymptomatic precursor of multiple myeloma (MM) and related disorders defined by abnormal free light chain (FLC) testing. Recently, revised FLC reference intervals were proposed by the iStopMM study group. We evaluated their performance in a large population-based cohort. MGUS cases were identified from the Danish Lymph

Correlations between event-by-event fluctuations of anisotropic flow harmonics are measured in Pb-Pb collisions at a center-of-mass energy per nucleon pair of 5.02 TeV, as recorded by the ALICE detector at the LHC. This study presents correlations up to the hexagonal flow harmonic v6, which was measured for the first time. The magnitudes of these higher-order correlations are found to vary as a fu

This paper presents the primary charged-particle multiplicity distributions in proton–lead collisions at a centre-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV. The distributions are reported for non-single diffractive collisions in different pseudorapidity ranges. The measurements are performed using the combined information from the Silicon Pixel Detector and the Forward Multiplic

The coherent J/ ψ photoproduction cross section is measured for the first time at midrapidity in peripheral to semicentral Pb−Pb collisions at sNN=5.02 TeV. The centrality differential cross section d σ /d y is reported for the centrality range 40–90%, together with the doubly-differential cross section d2 σ /d y d p T, extracted in two peripheral centrality classes. The J/ ψ mesons are reconstruc

This work reports femtoscopic correlations of p-−p(p‾-−p‾) and p−−d(p‾-−d‾) pairs measured in Pb–Pb collisions at center-of-mass energy per nucleon sNN = 5.02 TeV in the ALICE Collaboration. A fit to the measured proton-proton correlation functions allows one to extract the dependence of the nucleon femtoscopic radius of the particle-emitting source on the pair transverse mass (mT) and on the aver

This chapter provides a normative analysis of the CJEU’s centre of gravity theory in legal basis litigation, exposing a number of flaws in its application and presenting suggestions for improvement. The chapter discusses the difficulties in the delimitation of competences under the current constitutional setup, the CJEU’s inconsistencies in applying the criteria of aim and content under the centre

Membrane channels are central to bladder function, yet current understanding is shaped disproportionately by a few well-studied families such as TRPA1 and TRPV1. To provide a more balanced view, this review analyzed emerging human transcriptomic datasets to identify the channels most highly expressed in the urinary bladder and examined how they remodel in bladder outlet obstruction and denervation

BACKGROUND: Accreditation of cancer centres aims to deliver high-quality, person-centered care and underscores the integration with education, research, and innovation. Over the past decade, cancer centres in the Nordic countries have engaged in accreditation processes through the Organisation of European Cancer Institutes (OECI).OBJECTIVE: This study provides an overview of a rapidly evolving lan