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By Torches, Bones, and Temples : Material Metonyms in Personal Oaths in Latin Literature

Oath-taking during Roman Antiquity constitutes a telling example of how words and matter interplay and relate to one another. Ancient Latin literature provides a myriad of representations of oaths sworn, both fictive and supposedly historical, where matter somehow figure in the procedure. In this study, a selection of personal oaths from Roman literature are explored in terms of materiality and ag

The succession of ecological divergence and reproductive isolation in adaptive radiations

Adaptive radiation is a major source of biodiversity but the way in which known components of ecological opportunity, ecological differentiation, and reproductive isolation underpin such biodiversity patterns remains elusive. Much is known about the evolution of ecological differentiation and reproductive isolation during single speciation events, but exactly how those processes scale up to comple

Analog-to-Digital Converters for High-Speed Applications

This thesis delves into the multifaceted challenges of designing analog-to-digital converters (ADCs) tailored for high-speed and medium accuracy applications, particularly in deeply scaled-down CMOS technologies across five comprehensive chapters within its Introduction. Furthermore, it explores the evolution of mobile telephony from the first-generation (1G) to the last commercialized generation

Hormone receptor mRNA and protein levels as predictors of premenopausal tamoxifen benefit

Background and purpose: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomise

Phenological evolution in annual plants under light competition, changes in the growth season and mass loss

Flowering time is an important phenological trait in plants and a critical determinant of the success of pollination and fruit or seed development, with immense significance for agriculture as it directly affects crop yield and overall food production. Shifts in the growth season, changes in the growth season duration and changes in the production rate are environmental processes (potentially link

The engaged university delivering social innovation

This paper examines a programme initiated and managed by an entrepreneurial university in the United Kingdom (UK), aiming to foster the circular water economy in Sub-Saharan Africa. Our focus is on transitioning from conventional models of the entrepreneurial university to innovative forms of knowledge exchange that prioritise social innovation and sustainable development, as per the “engaged univ

Advancing X-ray imaging with deep learning : Physics-inspired reconstruction approaches

The development of high-brilliance X-ray sources, such as the fourth-generation diffraction-limited storage rings and X-ray free-electron lasers, have opened up new possibilities for X-ray imaging and pushed the temporal resolutions of imaging techniques to unprecedented levels. Capturing fast dynamics in two-dimensional (2D), three-dimensional (3D), and even four-dimensional (4D, 3D + time) beyon

Patient-Reported Outcomes (PROs) and PRO Remission Rates in 12,262 Biologic-Naïve Patients With Psoriatic Arthritis Treated With Tumor Necrosis Factor Inhibitors in Routine Care

Objective. To evaluate patient-reported outcomes (PROs) after initiation of tumor necrosis factor inhibitor (TNFi) treatment in European real-world patients with psoriatic arthritis (PsA). Further, to investigate PRO remission rates across treatment courses, registries, disease duration, sex, and age at disease onset. Methods. Visual analog scale or numerical rating scale scores for pain, fatigue,

Toward Accessible Biophotonics : Instrumentation for Insect and Vegetation Applications

Människors nyfikenhet och drivkraft att förstå och mäta vår värld har lett till många vetenskapliga framsteg. Vårt ständiga sökande efter kunskap har hjälpt oss att bland annat förhindra sjukdomar, förbättra skördar och förstå de ekosystem vi lever i. Dock varierar förutsättningar och utmaningar för forskning runt om i världen, och i många forskningsmiljöer saknas det tillgång till avancerad labor

Anticoagulation after liver transplantation: a retrospective audit and case-control study

Anticoagulation may in the future become a therapeutic option for the prevention of liver fibrosis, such as due to recurrent hepatitis C virus infection after liver transplantation. Currently, there are other indications for anticoagulation after liver transplantation but no data regarding its safety. The objective of the study was to audit the safety of anticoagulation after liver transplantation

Novel indices reveal that pollinator exposure to pesticides varies across biological compartments and crop surroundings

Declines in insect pollinators have been linked to a range of causative factors such as disease, loss of habitats, the quality and availability of food, and exposure to pesticides. Here, we analysed an extensive dataset generated from pesticide screening of foraging insects, pollen-nectar stores/beebread, pollen and ingested nectar across three species of bees collected at 128 European sites set i

Disease burden and unmet need for acute allergic reactions – A patient perspective

Background: Acute allergic reactions (AARs) occur shortly after exposure to an allergen, and the severity is on a continuum. Systemic corticosteroids (CS) are mainstay treatment of moderate to severe AARs, whereas those at risk of the most severe AARs (ie, anaphylaxis) are also recommended prescription of epinephrine autoinjectors. There is limited research on the impact of AARs not fulfilling the

Longitudinal ECG changes in tetralogy of Fallot and association with surgical repair

Background: ECG abnormalities have been linked to adverse changes in right ventricular (RV) morphology and poor clinical outcomes in repaired Tetralogy of Fallot (rTOF). Our aim was to describe how ECG changes progress in early and intermediate follow-up and whether types of surgical strategy at the time of primary repair affected these changes. Methods: We studied patients with rTOF born 2000–201

Pituitary Gonadotrophic Hormone Synthesis, Secretion, Subunit Gene Expression and Cell Structure in Normal and Follicle-Stimulating Hormone β Knockout, Follicle-Stimulating Hormone Receptor Knockout, Luteinising Hormone Receptor Knockout, Hypogonadal and Ovariectomised Female Mice

To investigate the relationship between gonadotroph function and ultrastructure, we have compared, in parallel in female mice, the effects of several different mutations that perturb the hypothalamic-pituitary-gonadal axis. Specifically, serum and pituitary gonadotrophin concentrations, gonadotrophin gene expression, gonadotroph structure and number were measured. Follicle-stimulating hormone β kn

Industrial policy for a circular industrial transition in Sweden: An exploratory analysis

Currently, both the US and the EU are pursuing industrial policies to support climate mitigation objectives. The climate transition will require increased use of material resources, but the envisioned industrial policies do not sufficiently address resource use, despite the current unsustainable global resource-use trajectory. The lack of industrial policy in this field is therefore relevant and t