Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and in

BACKGROUND Madagascar is the fourth biggest island and one of the poorest countries in the world, with more than 75 % of the 24 million inhabitants living under poverty line. The health care system in the country is under development, as well as the field of rehabilitation services and the area of prosthetic and orthotic services in specific. There is very limited published research concerning reh

To understand what is required to improve prosthetic and orthotic provision and services for persons with disabilities in low-income countries, it is of interest to investigate their well-being in terms of quality of life, access to mobility, education, health, rehabilitation, work and employment and their experiences of attitudes in the society. Data was collected using WHOQOL questionnaires meas

Although previous studies have shown that image production and visibility are central aspects of knowledge work, the assumption has been that this aspect of work is focused externally to support the organizational image and or uphold relationships with clients. In contrast, this paper explores the politics of knowledge work internally by focusing on how entrepreneurial employees in innovative know

Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance tes

The price of housing in Sweden has, over the past couple of decades, increased at a much faster rate than salaries. Politicians have tried to steer the housing market towards the provision of affordable housing, but have not succeeded. After 1993, the responsibility for regulating the price of housing transferred to the market, which is more interested in building for high-income earners. Despite

Ionotropic glutamate receptors are tetrameric ligand gated ion channels that mediate in ux and ef ux of metal ions in response to glutamate. Positive allosteric modulators of the ionotropic glutamate receptor 2 (GluA2) are promising lead compounds for drugs against cognitive disorders. These compounds bind within the dimeric interface formed by the receptor ligand binding domains (LBDs) attenuatin

The field flatness and the layout of the stabilization system in a drift tube linac are strongly dependent on the manufacturing errors that affect the local resonant frequency. In this paper a methodology is presented to study, firstly, the sensitivityof the resonant frequency and of the field flatness to each geometrical parameter of the drift tubes; then a set of tolerances for each parameter is

Making an accurate Radio Frequency, RF, design of any accelerating structure is fundamental to ensure that electromagnetic and beam dynamics requirements will be achieved. This is essential for the most complicated accelerating structureslike the Drift Tube Linac, DTL; in this case a meticulous design facilitates the RF commissioning too. In this paper the influence of the interfaces and of the fi

Background. The effects of different practices on fault distributions in evolving complex software systems is not fully understood. Software reuse and unit verification are prac- tices used to improve system reliability by minimising the number of late faults. Reused software benefits from already being verified while unit verification aims to find faults early.Aims. We want to study effects of so

Controlled experiments, also called A/B tests or split tests, are used in software engineering to improve products by evaluating variants with user data. By parameterizing software systems, multivariate experiments can be performed automatically and in large scale, in this way, controlled experimentation is formulated as an optimization problem. Using genetic algorithms for automated experimentati

Background: Fear of falling is common in people with Parkinson's disease (PD) and is associated with an increased risk for future falls, activity limitations and a reduced quality of life. The Falls Efficacy Scale-International (FES-I) assesses fear of falling conceptualized as concerns about falling. The original FES-I has good psychometric properties in people with PD, but whether this applies a

Background: Epidemiological studies of autoimmune hepatitis (AIH) show varying figures on prevalence and incidence, and data on the long-term prognosis are scarce. Objective To investigate the epidemiology, long-term prognosis and causes of death in a Swedish AIH cohort. Material and methods: Data collected from 634 AIH patients were matched to the Cause of Death Registry, and survival analyses we