RNA-directed transposon silencing operates in the mammalian soma and germline to safeguard genomic integrity. The piRNA pathway and the HUSH complex identify active transposons through recognition of their nascent transcripts, but mechanistic understanding of how these distinct pathways evolved is lacking. TASOR is an essential component of the HUSH complex. TASOR's DUF3715 domain adopts a pseudo-

As the world experiences increasing freshwater crises, researchers turn to saline waters. Can the use of saltwater be expanded? The development of appropriate practices for the use of saline waters for irrigation requires an adequate understanding of how salts affect waters, soils and plants, as FAO states in their book The use of saline waters for crop production, 1992. Plants can grow in saline

One novel option for treating metastatic castration resistant prostate cancer is radionuclide therapy targeting prostate-specific membrane antigen (PSMA), e.g. [177Lu]Lu-PSMA-617. Overexpression of HER2 has been found in 80% of metastatic cases of prostate cancer. Previous research showed that HER2 is elevated post irradiation in PC-3 prostate cancer cells. Co-treating with anti-HER2 antibody Tras

Många båtentusiaster skriver under på den romerske fältherren Pompejus bevingade ord navigare necesse est, att segla är nödvändigt. Länge var nöjessjöfarten i svenska farvatten dock förbehållen en privilegierad elit, ända tills fritidsbåtsmodeller, för segel och motor, utvecklades

Protein complexes constitute the primary functional modules of cellular activity. To respond to perturbations, complexes undergo changes in their abundance, subunit composition, or state of modification. Understanding the function of biological systems requires global strategies to capture this contextual state information. Methods based on cofractionation paired with mass spectrometry have demons

A well-defined terminology of fire-related variables is important for correct analyses and supporting knowledge-based decisions regarding the evaluation of building fires at the European level. After developing an overview of current practices for fire statistics in Part I, the terminology used and the data collected by the EU Member States and eight other countries regarding fire incidents, prope

Context dependence arises when ecological relationships vary with the conditions under which they are observed. Context dependence of interactions involving parasites is poorly known, even if it is key to understanding host–parasite relationships and food web dynamics. This paper investigates to which extent predation pressure on an avian ectoparasite (Carnus hemapterus) is context-dependent. Base

We describe the case of a 30-year-old woman, who needed a formal report on her visual impairment to seek support from society. She was born preterm, and during her neonatal period, she suffered from bilateral intraventricular hemorrhage (IVH) grade 3, a condition that can cause cerebral visual impairment (CVI) due to damage to the retro-geniculate visual pathways. Individuals with such brain damag

X-ray crystallography and X-ray spectroscopy using X-ray free electron lasers plays an important role in understanding the interplay of structural changes in the protein and the chemical changes at the metal active site of metalloenzymes through their catalytic cycles. As a part of such an effort, we report here our recent development of methods for X-ray absorption spectroscopy (XAS) at XFELs to