Colorectal cancer (CRC) patients with APC mutations do not benefit from 5-FU therapy. It was reported that APC physically interacts with POLβ and FEN1, thus blocking LP-BER via APC's DNA repair inhibitory (DRI) domain in vitro. The aim of this study was to elucidate how APC status affects BER and the response of CRC to 5-FU. HCT-116, HT-29, and LOVO cells varying in APC status were treated with 5-

Here, we report the p53 dependent mitochondria-mediated apoptotic mechanism of plant derived silver-nanoparticle (PD-AgNPs) in colorectal cancer cells (CRCs). PD-AgNPs was synthesized by reduction of AgNO3 with leaf extract of a medicinal plant periwinkle and characterized. Uptake of PD-AgNPs (ξ - 2.52 ± 4.31 mV) in HCT116 cells was 3 fold higher in comparison to synthetic AgNPs (ξ +2.293 ± 5.1 mV

This article seeks to explain the growth of identification and support for the Palestinian cause over the last decades from a regional concern to a global movement. What are the mechanisms that made this possible? This problematic is addressed within a cultural sociological framework, focusing on the cultural work of intellectuals and the collective actions of social movements in articulating and

Because internal transfers can play a key role in radiocaesium persistence in trees, a reliable representation of radiocaesium recycling between tree organs in forest models is important for long-term simulations after radioactive fallout in Chernobyl and Fukushima. We developed an upgraded 2.0 version of the initial TRIPS (“Transfer of Radionuclides In Perennial vegetation System”) model involvin

Forest fires are of special interest for Belarus because of radioactive contamination caused by the 1986 accident at the Chernobyl Nuclear Power Plant. This work aims to determine the potential activity of long-lived radionuclides in surface air caused by forest fires and to estimate the potential health threat to firefighters. The methodology is based on measurements of radioactivity released by

III-Nitride based LEDs based on InGaN active layers on GaN work very well for the blue and green emitting LEDs. However, the large lattice mis-match between redemitting active layers, with at least 35% indium in the active layers, and the GaN substrate still limits the efficiencies obtained to very low values. Unfortunately, the approach to use GaAs based (GaAs/AlInGaP) devices for the red fails f

In this paper, we present novel key-recovery attacks on Approximate Homomorphic Encryption schemes, such as CKKS, when employing noise-flooding countermeasures based on non-worst-case noise estimation. Our attacks build upon and enhance the seminal work by Li and Micciancio at EUROCRYPT 2021. We demonstrate that relying on average-case noise estimation undermines noise-flooding countermeasures, ev

Objective: To compare the effectiveness of JAK inhibitors (JAKis) and biologic disease-modifying antirheumatic drugs (bDMARDs) on pain in patients with rheumatoid arthritis. Methods: In this retrospective study, we investigated patients with a diagnosis of rheumatoid arthritis, starting treatment with a JAKi (n = 1,827), a tumor necrosis factor inhibitor (TNFi; n = 6,422), an interleukin-6 inhibit

Radar Cross Section measurement data is often analyzed using Inverse Synthetic Aperture Radar images. Backprojection is the conventional method to create these images but is limited in resolution. This paper builds on developments of ℓ1-minimization and iterative smooth reweighted ℓ1-minimization to get superresolution and adding another processing step with Gaussian smoothing. This step improves

This paper reports and demonstrates a packetponder for access/metro node consolidation and aggregation using common-form-factor pluggables (CFFP), which can simplify edge network architectures.

Purpose: This study aimed to investigate whether malnutrition or nutrition impact symptoms (NIS) affect the possibility of returning to work after treatment for head and neck cancer. Methods: Patients of working age with head and neck cancer were followed up from treatment initiation to 3 months (n = 238), 1 year (n = 182), and 2 years (n = 130) after treatment completion. The observed decrease in

Bark beetle infestations pose a significant threat to forest ecosystems, necessitating timely intervention for effective management and conservation. This study focuses on an 8,100 km2 area in southern Sweden, heavily impacted by a bark beetle outbreak triggered by a severe drought in 2018. Using spectral indices derived from Sentinel-2 data, it explores the potential of a window-based approach fo

Generation Z (Gen Z) will soon become the biggest living generation and the most dominant in terms of population and economic power, making them one of the tourism industry’s fastest-growing segments and a crucial market to target. There is growing evidence that Gen Z is concerned about the environmental and social effects of their consumption and is guided by strong ethical and environmental idea