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Popular Abstract in Swedish Bakgrund Alzheimers sjukdom (AD) är den vanligaste formen av demenssjukdom och svarar för ca 60 % av dessa patienter. Sjukdomen har en smygande debut och den sjukliga processen i hjärnan börjar troligen decennier innan den ger kliniska symptom som försämrat minne och organisationsförmåga, språksvårigheter, problem med tidsuppfattning och orientering. Även förmågan att uBackground Prospective longitudinal studies in Alzheimer's disease (AD) that include cholinesterase inhibitor (ChEI) treatment in routine clinical settings are scarce. The patients vary in severity of the disease, clinical course, rate of progression and response to treatment. Knowledge about the predicted course of the disease, sociodemographic and clinical factors affecting the outcome and the i

Artikeln undersöker uppkomsten och spridningen av den så kallade Veblen-Gerschenkronhypotesen, som går ut på att utländska företag och direktinvesteringar spelar stor roll i en industriell catch up-process. Hypotesen ”uppfanns” av Ronald Findlay 1978. Han kombinerade idéer från Thorstein Veblen 1915 och Alexander Gerschenkron 1952/1962 med en modell från Richard Nelson och Edmund Phelps 1966 och e

Our large brain, long life span and high fertility are key elements of human evolutionary success and are often thought to have evolved in interplay with tool use, carnivory and hunting. However, the specific impact of carnivory on human evolution, life history and development remains controversial. Here we show in quantitative terms that dietary profile is a key factor influencing time to weaning

Stroke causes life long disabilities where few therapeutic options are available. Using electrical and magnetic stimulation of the brain and physical rehabilitation, recovery of brain function can be enhanced even late after stroke. Animal models support this notion, and housing rodents in an enriched environment (EE) several days after experimental stroke stimulates lost brain function by multise

This article explores the phenomenon of in-kind remittances of maize and its implications for rural household livelihoods and food consumption. Interviews with a sample of 391 households in eight villages in Malawi are used to substantiate the discussion. Explanations for in-kind remittances are sought in the micro-level interaction between the formal market realm, informalised exchange systems an

Purpose: The purpose of this paper is to examine and explain what organizes the marketing of retail sustainability. Design/Methodology/Approach: Theoretically, this paper takes a marketing-as-practice approach and makes use of practice theory to conceptualize the marketing of sustainability. Methodologically, an ethnographic study of three Swedish retail chains and their marketing work has been c

Converging evidence indicates that women with pregnancy-associated breast cancer (PABC) have increased mortality compared to women with breast cancer not diagnosed near pregnancy (non-PABC). Our aim was to investigate if the stage distribution differs between PABC and non-PABC and if stage at diagnosis can explain the poorer prognosis observed among women with PABC. We identified 3,282 breast canc

Context. The first release of astrometric data from Gala will contain the mean stellar positions and magnitudes from the first year of observations, and proper motions from the combination of Gala data with HIPPARCOS prior information (HTPM). Aims. We study the potential of using the positions from the Tycho-2 Catalogue as additional information for a joint solution with early Gala data. We call t

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants exp

Heteroclitic monoclonal antibodies are characterized by the ability to bind multiple epitopes with little or no similarity. Such antibodies have been reported earlier, but insight into to the molecular basis of this propensity is limited. Here we report that the KIM185 antibody to human CD18 reacts with the plasma protein C4b-binding protein (C4BP). This was revealed during affinity purification p

Objectives To study regional cerebral blood perfusion with power Doppler ultrasound (PDU) imaging in appropriate-for-gestational age (AGA) fetuses and those with intrauterine growth restriction (IUGR) at different hemodynamic stages of fetal deterioration. Methods Brain blood perfusion was studied with PDU imaging, and the fractional moving blood volume (FMB V) was estimated in 56 growth-restricte

This document presents the 2012 evidence based guidelines of the Swedish Society of Infectious Diseases for the in-hospital management of adult immunocompetent patients with community-acquired pneumonia (CAP). The prognostic score 'CRB-65' is recommended for the initial assessment of all CAP patients, and should be regarded as an aid for decision-making concerning the level of care required, micro

Selecting the appropriate analytical methods for characterizing the assembly and morphology of polymer-based vesicles, or polymersomes are required to reach their full potential in biotechnology. This work presents and compares 17 different techniques for their ability to adequately report size, lamellarity, elastic properties, bilayer surface charge, thickness and polarity of polybutadiene-polyet

Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective l

In 2006 a palisade enclosure dated to the late Middle Neolithic was excavated at Bunkeflostrand, Malmö, Sweden. The excavation of pits and wells containing flints, animal bones and pottery revealed a wide range of activities at the site, which is exceptional in comparison with most other palisade enclosures of southern Scandinavia. Palisade enclosures have emerged as places of great significance t

Background: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis ( RA), and associate with HLA-DRB1 shared epitope (SE) alleles. Objective: To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their as

In insects, the surface area of the compound eye increases with body size both within and between species with only a slight negative allometry. This increase in surface area permits changes in eye structure that affect the eye's acuity and sensitivity, two features of eye performance that cannot be simultaneously maximized. Hence, as eye size varies within a lineage, so will the compromises betwe