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Recent studies have demonstrated that the transcription factor hepatocyte nuclear factor 4α (HNF4A) drives epithelial differentiation in the renal proximal tubules (PTs) and is critical for maintaining a mature PT phenotype. Furthermore, HNF4A down-regulation has been observed following kidney injury in mouse models. The aim of the present work was to investigate the role of HNF4A during acute and

Background: Local resection of early rectal cancer (RC) is a desirable treatment option compared with surgery, offering reduced morbidity, mortality, health care costs and avoidance of stoma. However, local resection is restricted to cases without suspicion of lymph node metastases (LNM). Current methods to diagnose LNM and risk estimations based on histopathology cannot reliably identify patients

We report on the experimental investigation of potential high-performance cavity length stabilization using odd-indexed higher-order spatial modes. Schemes based on higher-order modes are particularly useful for micro-cavities that are used for enhanced fluorescence detection of a few emitters, which need to minimize photons leaking from a stabilization beam. We describe the design and constructio

Aim: To describe healthcare utilization patterns among older people with intellectual disabilities in comparison to that of their age peers in the general population, including possible changes due to the COVID-19 pandemic. Subjects and methods: This was a Swedish longitudinal, register-based cohort study comprising 766 people aged 65+ years with intellectual disabilities (ID cohort) and 257 285 s

In the past years, anti-genderism has become a growing force in politics. The word ‘gender’ has become an empty signifier to attack queer and feminist agendas, sexual and reproductive rights but also gender studies scholars and courses. Social media, particularly Twitter stands out in the spread of anti-genderism despite its 280-character limit. Using political netnography and feminist critical di

This study presents a practical approach for characterizing industrial water-splitting nickel foam electrodes under both cathodic and anodic conditions by employing synchrotron radiation near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS). The in situ studies reveal quantitatively reduced and oxidized Ni species on the electrode surface by recording the Ni 2p3/2 signals after cycling

Branch groups stem from one of the most influential problems in group theory: The famous Burnside Problem, which arose in 1902 and asks if a finitely generated torsion group, i.e. in which every element has finite order, can be itself infinite. Now branch groups are groups acting on rooted trees, that have a rich tree-like subgroup structure. There are many examples of branch groups with remarkabl

This case report highlights the challenges in treating bronchopulmonary dysplasia (BPD) in a premature infant with severe pulmonary hypertension, recurrent pulmonary hypertensive crises, and the need of 100% oxygen to achieve acceptable arterial oxygen saturations. Key factors in the infant's improvement involved switching from pulmonary vasodilation to systemic afterload reduction using losartan,

Biofilms are highly organized, cooperating communities of microorganisms encased in a self-produced extracellular matrix, providing resilience against external stress such as antimicrobial agents and host defenses. A hallmark of biofilms is their phenotypic heterogeneity, which enhances the overall growth and survival of the community. In this study, we demonstrate that removing the dnaK and tig g

There is a strong societal demand for the development of effective and eco-friendly UV blocking substances for sunscreen applications. In this work, three AB2-type monomers with 0-2 methoxy groups are synthesized using three corresponding lignin-based monomeric aromatics and a potentially biobased hydandoin. The obtained AB2-type monomers are conveniently polymerized via conventional bulk polycond

Qualitative and quantitative visualizations of transonic turbomachinery flows provide essential information on compressibility and Mach number effects on boundary layer development, shock-boundary layer interactions, and trailing edge flows. Background oriented Schlieren (BOS) is a relatively new optical technique that allows capturing unsteady density gradient fields through turbomachinery cascad

Nature sounds are often seen as relaxing, and understood as reconnecting our minds and bodies with something primeval. Such sounds are used for stress recovery in the fields of medicine and psychology, as well as in our personal meditation app downloaded on our phone. At the same time a continuous climate anxiety has invaded many personal experiences in relation to nature environments and phenomen

ObjectivesStructural defects during fenestrated endovascular aortic repair (FEVAR) can be difficult to identify only on two-dimensional imaging. This study aims to assess the potential additional value of routine intraoperative completion plain cone-beam computed tomography (CBCT) in identifying such defects during FEVAR.MethodsA retrospective review of all consecutive FEVARs performed at a tertia

Objective Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare disease that can result in severe bleeding in a fetus or newborn, including intracranial hemorrhage. Maternal-fetal human platelet antigen (HPA)-1a incompatibility is a prerequisite to maternal HPA-1a alloimmunization, which may result in FNAIT. The risk of HPA-1a alloimmunization is approximately 25-times higher in HPA-1

Understanding the influence of land use/land cover (LULC) on stream water quality (WQ) is essential for conservation of ecosystem services (ES) and informing sustainable land use planning. This study investigates the influence of LULC on stream WQ during the wet and dry seasons 2022–2024, across two representative watersheds in the Bolivian central Andes, a region with marked physical gradients, a