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Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune processes and β-cell dysfunction are known to occur in type 1 diabetes, a complete understanding of the cell-to-cell interactions that support pancreatic function is still lacking. To characterize the pancreatic endocrine compartment, we stu
PURPOSE: Children with cerebral palsy (CP) have an increased risk of cognitive difficulties and should be offered cognitive assessments. In Sweden, the CP Cog protocol recommends children with CP undergo cognitive assessments at the start of primary and secondary school. To assess children with CP can be challenging, in particular when children are non-vocal or do not speak the local language. In
Civilingenjörsutbildningen i Ekosystemteknik startade höstan 1998 med antagning av 30 studenter. Samtidigt startade även Industriell ekonomi. De två utbildningarna kom till för att möta ett utökat uppdrag från statsmakternas till Lunds universitet avseende utfärdade civilingenjörsexamina. Efter ett förhållandevis snabbt och intensivt planeringsarbete beslutade LTH:s styrelse i februari 1998 om att
In recent years, the analysis of abrupt and non-abrupt changes in precipitation has received much attention due to the importance of climate change-related issues (e.g., extreme climate events). In this study, we used a novel segmentation algorithm, DBEST (Detecting Breakpoints and Estimating Segments in Trend), to analyze the greatest changes in precipitation using a monthly pixel-based satellite
Humanity is at a crossroads in addressing biodiversity loss. Several assessments have reported on the weak compliance with the Aichi Biodiversity Targets by the parties to the Convention on Biological Diversity (CBD). To address this lack of compliance, the challenges in implementing and enforcing CBD obligations must be understood. Key implementation challenges of the CBD are identified through a
Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of ph
Savannas cover a wide climatic gradient across large portions of the Earth’s land surface and are an important component of the terrestrial biosphere. Savannas have been undergoing changes that alter the composition and structure of their vegetation such as the encroachment of woody vegetation and increasing land-use intensity. Monitoring the spatial and temporal dynamics of savanna ecosystem stru
Vapor pressure deficit (VPD) is of great importance to control the land-atmosphere exchange of water and CO2. Here we use in situ observations to assess the performance of monthly VPD calculated from state-of-the-art data sets including CRU, ERA5, and Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA2). We investigate trends in VPD at global scale and for different
Som forskare i skärningspunkten mellan teologi och barndomsstudier delar vi upplevelsen av att när vi presenterar vår forskning i olika sammanhang mötas av vad vi tolkar som en okritisk teologisk barnsyn, som inte tar hänsyn till enskilda barns erfarenheter. I den här artikeln undersöker vi hur teologi och teologiska praktiker utmanas av att lyssna till barn som själva deltar i dessa praktiker. ViIn this article we discuss and problematise what we perceive as an uncritical theological view of children. Such a view does not take the experiences of particular children into account but constructs a universal understanding of children and childhood. Here we wish to explore how theology is challenged by listening to children who themselves take part in theological practices. The material we emp
More than a decade ago the WHO Health Promoting Hospitals project was initiated in order to support hospitals towards placing greater emphasis on health promotion and disease prevention, rather than on diagnostic and curative services alone. Twenty hospitals in eleven European countries participated in the European pilot project from 1993 to 1997. Since then, the International Network of Health Pr
Parkinson´s disease (PD) is one of the most common neurological diseases with both motor and non-motor symptoms that can be perceived as difficult to control despite medical treatment. This leads to several consequences in everyday life for example difficulties in activities of daily living (ADL), sometimes already at diagnosis. Therefore, rehabilitation is important to manage the consequences of
Acute myeloid leukemia (AML) is a heterogeneous disease with variable patient responses to therapy. Selinexor, an inhibitor of nuclear export, has shown promising clinical activity for AML. To identify the molecular context for monotherapy sensitivity as well as rational drug combinations, we profile selinexor signaling responses using phosphoproteomics in primary AML patient samples and cell line
