By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their intracellular concentrations and their biological effects. As these intracellular second messengers control many cellular homeostatic processes, dysregulation of their signals and signaling pathways initiate or modulate p

Despite weak evidence, the use of acupuncture has increased in infantile colic. The only three randomized trials conducted evaluated standardized minimal acupuncture in one single point. Two showed effect but one did not so further research is necessary. The aims of the study are 1) to test if results in earlier trials conducted in private acupuncture clinics can be repeated at Child Health Center

This contribution highlights recent results from the PHENIX Collaboration at RHIC with emphasis on those obtained through lepton and photon measurements in PHENIX.

An ultrastructural study of the intestine of Derocheilocaris typica revealed an organization of the midgut musculature, which is unique in the Crustacea. This species unusual anal skeletomusculature has also not been seen before. The intestinal musculature of D. typica displays different patterns in the fore-, mid-, and hindgut. Around the foregut, eight pairs of dilator muscles complement a conti

High-quality GaSb nanowires (NWs) have been synthesized via chemical vapor deposition. The as-synthesized NWs have a zinc-blende structure with growth direction along a < 011 > direction. Raman spectrum of the GaSb NWs consists of two peaks, corresponding to the LO and TO phonon modes, respectively. The temperature dependence of the photoluminescence spectra shows a blue-shift as the temperature d

Project retrospectives can be powerful tools for project teams to collectively identify communication gaps and practices to improve for future projects. However, even if project members take the time for a retrospective, it can be hard to correctly remember and jointly discuss past events in a constructive way. Fact-based timelines that visualize a project's events offer a possible solution.

A book printer and a bookseller in Copenhagen – Claude Philibert’s connection with the Societé typographique de Neuchatel 1771-1783. In 1755 Claude Philibert came from Geneva to Copenhagen, where he establishedhimself as a bookseller. Until the 28th of April 1775 he was also a partner in a publishing bookshop and printer’s business in Geneva, which was run by Barthélemy Chirol. On the 3rd of Augus

Dynamics of laser-induced plasma plume studied by cavity ring-down spectroscopy (CRDS) was simulated by a numerical model. Velocity distribution and anisotropy of the plume with temporal and geometrical characteristics of CRDS were included. Behavior of spectral lineshapes was studied in respect to various experimental parameters.

Background: Nonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise from different processes, including erroneous processing and expression of pseudogenes, but also from more regulated events such as alternative splicing co

Studies of epithelial cancers (i.e., carcinomas) traditionally focused on transformation of the epithelium (i.e., the cancer cells) and how aberrant signaling within the cancer cells modulates the surrounding tissue of origin. In more recent decades, the normal cells, blood vessels, molecules, and extracellular components that surround the tumor cells, collectively known as the "tumor microenviron

The ALICE Collaboration has measured inclusive J/psi production in pp collisions at a center-of-mass energy root s = 2.76 TeV at the LHC. The results presented in this Letter refer to the rapidity ranges vertical bar y vertical bar < 0.9 and 2.5 < y

This article discusses how Chicago police representatives have expressed their understanding of the events at haymarket Square on the 4th of May, 1886 and the commemoration of the bombing and its aftermath in trials and hangings.

Recension av en existentiell biografi om drottning Victoria, som fokuserar mycket på hennes religiösa liv och hennes pliktmedvetande, samt illustrerar hur hon kan betraktas som tillhörande "förlorarnas historia".

The Tree Theme Method (TTM) is an intervention based on sessions involving creative activities and life storytelling/story-making, in which the client paints trees representing various periods of his/her life. The aim of this study was to investigate clients' experiences of participating in a TTM intervention and their perceptions of the therapeutic relationship. Thematic interviews were undertake

In Frisch grid ionization chambers special attention must be paid to the operating voltages in order to avoid unwanted collection of electrons on the Frisch grid. Collection of electrons on the grid will lead to a decreased signal to noise ratio and consequently a deteriorated energy resolution. Furthermore, systematic errors in the determination of the angular distribution will be introduced. The

Background: Early hospital arrival and rapid intervention for acute myocardial infarction is essential for a successful outcome. Several studies have been unable to identify explanatory factors that slowed decision time. The present study examines whether personality, psychosocial factors, and coping strategies might explain differences in time delay from onset of symptoms of acute myocardial infa