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Concussion, caused by a rotational acceleration/deceleration injury mild enough to avoid structural brain damage, is insufficiently captured in recent preclinical models, hampering the relation of pathophysiological findings on the cellular level to functional and behavioral deficits. We here describe a novel model of unrestrained, single vs. repetitive concussive brain injury (CBI) in male C56Bl/

International law is becoming increasingly more specialized and diversified. In response to these developments, international lawyers now widely refer to international investment law, European human rights law and many other branches as ‘special regimes’. Scholars in the field see the proliferation of special regimes as a threat to the unity of the international legal system. In so doing, they are

The paper presents new geological, geochronological, geochemical and Nd-Sr isotopic data on the Meso- Neoproterozoic dolerites of the Siberian Craton. New U-Pb baddeleyite and apatite ages of a E-W-trending dyke and two sills from southeastern Siberia are 982 ± 11, 977 ± 7, 970 ± 31 and 972 ± 60 Ma, respectively, extending the area of distribution of the event by more than 100 km to the north. The

The mammalian skin is a densely innervated soft tissue where neural mechanoreceptors embedded in the skin report to the brain the mechanical events arising at its surface. Up to now, models of the transformations of these events into neural signals relied on quasi-static or viscoelastic mechanical models of the skin tissue. Here we developed a model, which, in addition to elasticity and viscosity,

Progenitor cells adapt their behavior in response to tissue demands. However, the molecular mechanisms controlling esophageal progenitor decisions remain largely unknown. Here, we demonstrate the presence of a Troy (Tnfrsf19)-expressing progenitor subpopulation localized to defined regions along the mouse esophageal axis. Lineage tracing and mathematical modeling demonstrate that Troy-positive pro

Four isostructural oxovanadium(V) complexes with hydrazone ligands have been synthesised, characterised, and evaluated as epoxidation and sulfoxidation catalysts. The reactions between [VO(acac)2] (acac– = acetylacetonate) and H2Ln (n = 1–4), precursors for monoanionic tridentate hydrazone ligands, afford complexes formulated as [VO(Ln)(bzh)·MeOH] (1–4) when bidentate benzohydroxamic acid (Hbzh) i

This paper constructs annual GDP estimates for Ireland (1924-47) to join the first complete official aggregates. The new series is deployed to revisit Ireland’s economic performance in the post-independence decades. Ireland’s economy grew at 1.5 per cent per annum and average living standards improved by 40 per cent. The bulk of this was due to labour productivity improvements stemming from worker

Subject movements and other disturbances might contaminate the Magnetic Resonance Spectroscopy data, and these artifacts can be misinterpreted as actual metabolite signals by the quantification program. Thus, an automatic method could be very helpful for finding artifacts and eliminating them. In this work, an approach of using correlation analyses was tested in order to evaluate if motion contami

Recension av Lennart Pehrson, "Vithetens lön: En historia om rasism"

This volume engages with the alarming convergence of far right thinking and the ecological crisis in contemporary society. Growing out of the first international conference on political ecologies of the far right, the volume gathers crucial insights from authorities in the field as well as promising early career researchers. With cases ranging from ethnographical accounts of fossil fuel populist p

Detecting failures early in cloud-based software systems is highly significant as it can reduce operational costs, enhance service reliability, and improve user experience. Many existing approaches include anomaly detection in metrics or a blend of metric and log features. However, such approaches tend to be very complex and hardly explainable, and consequently non-trivial for implementation and e

With the dynamic nature of modern software development and operations environments and the increasing complexity of cloud-based software systems, traditional monitoring practices are often insufficient to timely identify and handle unexpected operational failures. To address these challenges, this paper presents the findings from a quantitative industry survey focused on the application of Machine

The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, with an increased mortality risk for people with Alzheimer's disease (AD) and/or Down syndrome (DS). However, few studies have evaluated the neuropathological and inflammatory sequelae in postmortem brain tissue obtained from AD and people with DS with severe SARS-CoV-2 i

Environmental degradation is one of the most significant challenges faced by humanity, yet current global politics struggle to implement collective solutions. Previous research has suggested that the EU has a leadership role in the international climate change regime complex, which refer to a set of overlapping institutions that address different aspects of climate governance. Moreover, within the

Recent research into migration in Bangladesh has highlighted that people migrate for better livelihoods, not necessarily in response to climatic stresses and shocks. If facilitated appropriately, internal and international migration can help build adaptive capacity to future environmental and climatic hazards. In this framing, migration happens in the context of a growing city-centred economy that

We investigate mean-field games from the point of view of a large number of indistinguishable players, which eventually converges to infinity. The players are weakly coupled via their empirical measure. The dynamics of the states of the individual players is governed by a non-autonomous pure jump type semi group in a Euclidean space, which is not necessarily smoothing. Investigations are conducted