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Acute myeloid leukemia (AML) is a heterogeneous disease of the myeloid lineage. About 35% of AML patients carry an oncogenic FLT3 mutant making FLT3 an attractive target for treatment of AML. Major problems in the development of FLT3 inhibitors include lack of specificity, poor response and development of a resistant phenotype upon treatment. Further understanding of FLT3 signaling and discovery o
The present article analyses the mediatization of the brand and celebrity Zlatan Ibrahimovic using the reception and marketing of the footballer's life story and autobiography as its main case. It is shown that the construction of a myth such as Ibrahimovic transcends the materiality of the book as well as geographical, vernacular and media boundaries, as it is constituted as content in a digital
This article proceeds from a conceptual analysis of how ontological (in)security is constructed in terms of ‘security-of-being’ in which identity dynamics are explicated in socio-psychological terms. Of particular interest is how such dynamics transcend the boundaries of individual self/other constructions to define communities and states, and how these dynamics are transformed in times of trauma
The article examines leader ship as an aspect of everyday work inter actions. Drawing on the findings of an ethnographically inspired study of superior-subordinate relations in a bank, it argues that leader ship can be understood as embedded in everyday work-activities, rather than seen as distinct from these. Relying on the framework of discursive psychology, a micro-level analysis of an informal
The complexity status of the minimum r-star cover problem for orthogonal polygons had been open for many years, until 2004 when Ch. Worman and J. M. Keil proved it to be polynomially tractable (Polygon decomposition and the orthogonal art gallery problem, IJCGA 17(2) (2007), 105-138). However, since their algorithm has (O) over tilde (n(17))-time complexity, where (O) over tilde (.) hides a polylo
Background: Evolutionary biologists are often misled by convergence of morphology and this has been common in the study of bird evolution. However, the use of molecular data sets have their own problems and phylogenies based on short DNA sequences have the potential to mislead us too. The relationships among clades and timing of the evolution of modern birds (Neoaves) has not yet been well resolve
Background: Earlier studies have found a positive effect of alcohol consumption, with a reduced disease activity in rheumatoid arthritis (RA). The aim of this study was to assess alcohol consumption and its association with disease activity and health related quality of life (HRQL) in Swedish RA patients. Methods: Between 1992 and 2005, 2,800 adult patients were included in the BARFOT study of ear
The collection examines the view of the holiness in the "Holy Land" through the writings of pilgrims, travelers, and missionaries. The period extends from 1517, the Ottoman conquest of Syria and Palestine, to the Franco-British treaty of Utrecht in 1713 and the consolidation of European hegemony over the Mediterranean. The writers in the collection include Christians (Orthodox, Protestant, and Cat
The feather moss Pleurozium schreberi (Brid.) Mitt. is colonized by cyanobacteria, which fix substantial amounts of atmospheric nitrogen (N) in pristine and N-poor ecosystems. Cyanobacterial N-2 fixation is inhibited by N deposition. However, the threshold of N input that leads to the inhibition of N-2 fixation has not been adequately investigated. Further, the ability of N-2 fixation to recover i
En populärvetenskaplig introduktion till Mary Wollstonecrafts (1759-1797) politiska tänkande.
"Mossor, lavar och svampar i naturvården" heter en universitetskurs i Lund. På kursen är man mycket i fält och avslutar även med en inventering av ett mindre område. Varje gång kursen ges hittar man intressanta arter och 2014 var inget undantag. Ovanligt många roliga fynd gjordes och Ulf Arup ger här en kort beskrivning av de intressantaste fynden.
Earlier studies on women's health and drinking and the contemporary associated risk factors have highlighted the need for more complex approaches in understanding the pathways into women's problem drinking. Research, from both social science and from occupational therapy models, has underlined the importance of deconstructing the often dichotomized way of investigating women's daily lives (such as
CITED1 is a non-DNA binding transcriptional co-regulator whose expression can distinguish the 'proliferative' from 'invasive' signature in the phenotype-switching model of melanoma. We have found that, in addition to other 'proliferative' signature genes, CITED1 expression is repressed by TGFβ while the 'invasive' signature genes are upregulated. In agreement, CITED1 positively correlates with MIT
Aim: Outcome is uncertain in infants born at 23-24 gestational weeks. The aim of the present study was to identify possible early predictors of outcome in these infants. Materials and Methods: Data from the Swedish medical birth register (MBR) for live-born infants with gestational ages (GAs) 23 and 24 weeks, born during the time-period 2000-2002, were analysed in relation to short-term outcomes,
UV-curable acrylates are the base for a large and growing product group within the coatings industry. Traditional chemical catalysis is poorly suited for acrylation reactions since these require low temperatures to avoid polymerization. In this study, immobilized Candida antarctica lipase B has been used to efficiently acrylate four polymers through transesterification of ethyl acrylate, via a sol
Background: To explore the patients' experiences during the three decades following repair of a nerve injury in the forearm and its consequences for daily life. Strategies that were used to facilitate adaptation were also investigated. Methods: Fifteen participants with a complete median and/or ulnar nerve injury repaired in the ages from 13-20 years were interviewed using a semi-structured interv
