Basal-like breast cancer (BBC) is a subtype of breast cancer with poor prognosis1, 2, 3. Inherited mutations of BRCA1, a cancer susceptibility gene involved in double-strand DNA break (DSB) repair, lead to breast cancers that are nearly always of the BBC subtype3, 4, 5; however, the precise molecular lesions and oncogenic consequences of BRCA1 dysfunction are poorly understood. Here we show that h

It is well known that user proximity introduces absorption and impedance mismatch losses that severely degrade multiple-input multiple-output (MIMO) performance of handset antennas. In this work, we experimentally verified the potential of adaptive impedance matching (AIM) to mitigate user interaction effects and identified the main AIM gain mechanism in realistic systems. A practical setup includ

The finite element method is used to analyze the stability of a cantilever column resting on elastic foundation and subjected to an eccentric slave load at its free end. The analysis has been conducted according to Bernoulli-Euler and Timoshenko beam theories. Effects of the mass offset, coupling effects and damping has been taken into account.

BACKGROUND: There is a growing awareness of the importance of intracellular events in determining the outcome of infectious disease. To improve the understanding of such events, like phagosome maturation, we set out to develop a versatile technique for phagosome isolation that is rapid and widely applicable to different pathogens. RESULTS: We developed two different protocols to isolate phagosomes

Detta föredrag vid en stiftshistorisk dag lyfter fram det enda kända fall där en svensk präst vägrat tvångsdöpa ett baptistbarn som hämtats till dop av länsman. Sådan vägran förekom flera gånger i Danmark. Barnet, som var brorsdotter till baptistpionjären F. O. Nilsson, döptes några dagar senare "på pastors inrådan och moderns begäran", men fallet behandlades ändå i domkapitlet, där Nordblom så sm

Oscillator strengths for the three 3s(2)3p(3)4s S-3(1)o-3s(2)3p(3)4p P-3(0,1,2) transitions in neutral sulphur have been determined directly from lifetime measurements. Two-photon UV laser excitation and subsequent fluorescence detection have been used on atoms produced in a thermal sulphur beam or in a laser-driven plasma. A good agreement was found between data obtained in both schemes. The life

Background: Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. The aim of this study was to evaluate the effect of simvastatin on cholestasis-induced liver inflammation and tissue damage. Experimental approach: C57BL/6 mice were treated with simvastatin (0.02 and 0.2 mg.kg(-1)) and vehicle before and after undergoing bile duct ligation (BDL) for 12 h. Leu

Successful tissue engineering with the aid of a polymer scaffold offers the possibility to produce a larger construct and to mould the shape after the defect. We investigated the use of cryogelation to form protein-based scaffolds through different types of formation mechanisms; enzymatic crosslinking, chemical crosslinking, and non-covalent interactions. Casein was found to best suited for enzyma

PURPOSE: To investigate retinal function after reduction of intraocular pressure (IOP) by filtration surgery in patients with medically uncontrolled glaucoma. METHODS: Eleven patients (11 eyes) with medically uncontrolled glaucoma underwent trabeculectomy. Clinical investigation, visual field (testing with standard automated perimetry (SAP-Humphrey), optical coherence tomography (OCT), full-field

Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined i