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α-Synuclein aggregates constitute the pathology of Lewy body (LB) disease. Little is known about the effects of LB pathology in preclinical (presymptomatic) individuals, either as isolated pathology or coexisting with Alzheimer's disease (AD) pathology (β-amyloid (Aβ) and tau). We examined the effects of LB pathology using a cerebrospinal fluid α-synuclein-seed amplification assay in 1,182 cogniti
This chapter provides an introduction to task engagement as a framework for better understanding how individuals participate in and learn from second language activities in their leisure time. Although the concept is relatively new to second language acquisition research, engagement has been extensively studied in educational science, as a way of operationalising different aspects of students’ par
There is poor knowledge about the clinical effects of Lewy body (LB) pathology in patients with cognitive impairment, especially when coexisting with Alzheimer's disease (AD) pathology (amyloid-β and tau). Using a seed amplification assay, we analyzed cerebrospinal fluid for misfolded LB-associated α-synuclein in 883 memory clinic patients with mild cognitive impairment or dementia from the BioFIN
BACKGROUND: 4-hydroxychlorothalonil (HCT, R182281), a transformation product of the fungicide chlorothalonil, was recently identified in human serum and breast milk. There are indications that HCT may be more toxic and environmentally persistent than chlorothalonil.OBJECTIVE: Our aim was to investigate serum concentrations of HCT in pregnant women in Sweden and Costa Rica.METHODS: We developed a q
The various structural components of the cortical degeneration of Alzheimer's disease were defined and graded. The severity of the degenerative process was thus mapped in different cortical areas where neuronal numbers and cortical width were also measured and compared with controls. Contrary to the general opinion that the degenerative process is rather uniformly diffuse, though accentuated in th
The aim of the article is to correlate grey and white matter changes and their topography to the results of modern methods for brain imaging such as CT, rCBF, PET, SPECT and NMR in Alzheimer's type of dementia. The findings are based on the study of a large material investigated thoroughly patho-anatomically. The findings are correlated with psychiatric and neurophysiologic follow-up studies. The
Dietary interventions modify gut microbiota and clinical outcomes. Weight reduction and improved glucose and lipid homeostasis were observed after adopting an Okinawan-based Nordic diet (O-BN) in individuals with type 2 diabetes. The aim of the present study was to explore changes in metabolomics and gut microbiota during O-BN and correlate changes with clinical outcomes. A total of 30 patients (1
When talking about products, people often express their needs in vague terms with vocabulary that does not necessarily overlap with product descriptions written by retailers. This poses a problem for chatbots in online shops, as the vagueness and vocabulary mismatch can lead to misunderstandings. In human-human communication, people intuitively build a common understanding throughout a conversatio
How variations in carbon supply affect wood formation remains poorly understood in particular in mature forest trees. To elucidate how carbon supply affects carbon allocation and wood formation, we attempted to manipulate carbon supply to the cambial region by phloem girdling and compression during the mid- and late-growing season and measured effects on structural development, CO2 efflux and nons
Diatoms are an important group of eukaryotic microalgae, which play key roles in marine biochemical cycling and possess significant biotechnological potential. Despite the importance of diatoms, their regulatory mechanisms of protein synthesis at the translational level remain largely unexplored. Here, we describe the detailed development of a ribosome profiling protocol to study translation in th
Financial accounting is a process that goes from the company’s transactions, through the accounting system and production of financial statements, to the use and analysis of the information by external parties. The analysis of financial statements is the basis for many important decisions. This book explains the fundamental role of financial accounting in the economy.The book covers both technicalFinancial accounting is a process that goes from the company’s transactions, through the accounting system and production of financial statements, to the use and analysis of the information by external parties. The analysis of financial statements is the basis for many important decisions. This book explains the fundamental role of financial accounting in the economy.The book covers both technical
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy techniques have been used extensively for metabolite profiling. Although combining these two analytical modalities has the potential of enhancing metabolite coverage, such studies are sparse. In this study we test the hypothesis that combining the metabolic information obtained using liquid chromatography (LC) MS and 1H NMR s
Inom forskningen refererar självskadebeteende till beteenden med låg dödlighet och där suicidintention är osannolikt, så som att skära, slå, och bränna sig själv. Denna avhandling ämnade undersöka; i) mental hälsa och välmående bland svenska unga vuxna som har slutat skada sig sedan tonåren, och ii) de psykosociala faktorerna som bidrar till att en slutar skada sig och mår bättre under denna perioNon-suicidal self-injury (NSSI) is an umbrella term for non-lethal behaviours that are unlikely to be intended as suicidal, such as cutting, hitting, or burning oneself. The aims of this dissertation were to investigate i) the mental health and well-being of Swedish young adults who have ceased engaging in NSSI since adolescence, and ii) the psychosocial conditions that facilitate NSSI cessation a
In this work we use the method of eigenfamilies to construct explicit complex-valued proper p-harmonic functions on the compact real Grassmannians. We also find proper p-harmonic functions on the real flag manifolds which do not descend onto any of the real Grassmannians
Background: Choice theory stems from psychological concepts like self-concept, successful identity, and quality of the world. The theory encourages adolescents to accept the responsibility for their choices on the one hand and predict the effect of such decisions on their lives on the other hand. The present study aimed to investigate the effectiveness of choice theory-based group training in inte
Pathological disturbance to one's identity is closely linked with mental illness and in particular personality disorders. Current measures of identity pathology within clinical research are nevertheless inconsistently used and present with substantial limitations such as disproportionate focus on adolescence. The Self-Concept and Identity Measure (SCIM) identifies pathological and non-pathological
BACKGROUND: Studies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagn
BACKGROUND: Pragmatic language is key for adaptive communication, but often compromised in neurodevelopmental conditions such as autism spectrum disorder (ASD). Decontextualized language-to talk about events and things beyond here and now-develops early in childhood and can be seen as a pre-pragmatic ability. Little is known about the factors that contribute to decontextualized language use in tod
