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A set of nineteen C-galactopyranosyl ligands, which included constrained compounds based on a bicyclic trans-decalin type system. were synthesized via click chemistry from 2-(β-d-C-galactopyranosyl) ethylene azide intermediates. The compounds were evaluated for binding to various galectins and the most promising inhibitor from the series was a constrained 3-O-benzylated galactopyranose derivative,

During the 2015–2018 data-taking period, the Large Hadron Collider delivered proton-proton bunch crossings at a centre-of-mass energy of 13 TeV to the ATLAS experiment at a rate of roughly 30 MHz, where each bunch crossing contained an average of 34 independent inelastic proton-proton collisions. The ATLAS trigger system selected roughly 1 kHz of these bunch crossings to be recorded to disk. Offli

Recovery Colleges (RCs) are learning-based mental health recovery communities, located globally. However, evidence on RC effectiveness outside Western, educated, industrialised, rich, and democratic (WEIRD) countries is limited. This study aimed to evaluate associations between cultural characteristics and RC fidelity, to understand how culture impacts RC operation. Service managers from 169 RCs s

This paper presents a measurement of jet-track correlations in photon-jet events, using 1.72 (Formula presented) of (Formula presented) data at (Formula presented) recorded with the ATLAS detector at the LHC. Events with energetic photon-jet pairs are selected, where the photon and jet are approximately back-to-back in azimuth. The angular correlation between jets and charged-particle tracks with

Congenital anomalies of the kidneys and urinary tract (CAKUT) are developmental disorders that commonly cause pediatric chronic kidney disease and mortality. We examine here rare coding variants in 248 CAKUT trios and 1742 singleton CAKUT cases and compare them to 22,258 controls. Diagnostic and candidate diagnostic variants are detected in 14.1% of cases. We find a significant enrichment of rare

Objective: Establishing the incidence and types of complications following surgical intervention for ARM, primarily after reconstruction. Patient- and treatment-related risk factors were also determined. Background: Postoperative complications of ARM surgery vary widely, with data predominantly derived from single-center retrospective studies with limited number of patients. Whether factors such a

Supercrystals of lead-halide perovskite nanocrystals combine the semiconducting properties of bulk perovskites with quantum confinement effects and extend them to the macroscopic scale. Supercrystals assembled via a two-layer phase diffusion process using an acetonitrile antisolvent were recently shown to be unusually robust. We investigate how the acetonitrile-assisted self-assembly process influ

Battery electric trucks and autonomous driving systems are each approaching commercial viability for long-haul freight. Current development treats these technologies as independent improvements to diesel operations. This thesis examines the operational and economic synergies that emerge when autonomy and Megawatt Charging System infrastructure are deployed together rather than in isolation. The a

Infective endocarditis (IE) is most often caused by alpha-hemolytic streptococci or Staphylococcus aureus and is characterized by the presence of vegetations on the heart valves. Here we present a case of IE caused by Streptococcus pyogenes, a distinctly uncommon IE-pathogen, where no vegetations could be visualized on repeated echocardiography. Diagnosis was instead evident from septic embolizati

Denna forskningsrapport inom ramen för ett MSB uppdrag identifierar och kartlägger relevanta datamängder för att bedöma tvärsektoriella sårbarheter för samhällsviktiga verksamheter och kritiska infrastrukturer på nationell svensk nivå. Totalt identifierades 108 datamängder, varav 49 bedöms vara relevanta för analyser på nationell nivå, 54 på regional nivå och 37 på lokal nivå. Identifierad och samThis commissioned research report identifies and maps out relevant data sets to assess cross-sectoral vulnerabilities of vital societal functions and critical infrastructures at a Swedish national level. In total 108 data sets were identified, of which 49 are deemed to be relevant for analyses at the national level, 54 at the regional level and 37 at the local level. Although of high usefulness fo

In recent years, weather-related extreme events have shown the limits of technical approaches to urban water challenges and highlighted the urgent need to rethink the relationship between cities and water and to see water as a partner in shaping transformative, climate-safe and just urban futures. However, existing scientific studies depicting future trajectories of urban water management have str

INTRODUCTION: Health promotion in everyday settings is of great importance for both individual health and organizational sustainability. A settings-based approach emphasizes how social, physical, and organizational contexts shape the conditions for health. Central principles in health promotion are participation, empowerment, and person-centeredness, which emphasize the active role of the person o

An assessment of the global progress in climate change adaptation is urgently needed. Despite a rising awareness that adaptation should involve diverse societal actors and a shared sense of responsibility, little is known about the types of actors, such as state and non-state, and their roles in different types of adaptation responses as well as in different regions. Based on a large n-structured

A less studied aspect in research on globalisation and outsourced production is how work in the global value chain is infused with precarity and may even become a space of harassment and violence, including sexual abuse. This themed section seeks to contribute to the literature on gender-based violence in factories where production has been outsourced to the Global South, especially Asia. In this

This narrative Review explores the role of hyperinsulinaemia as a potential independent contributor to obesity and cardiometabolic diseases. We argue that scientific discussions about the role of hyperinsulinaemia as a causal factor in these conditions have not sufficiently distinguished between postprandial insulin excursions and chronically elevated basal levels of insulin. We summarize findings