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Caveolae are omega-shaped plasma membrane micro-domains that are abundant in cells of the vascular system. Formation of caveolae depends on caveolin-1 and cavin-1 and lack of either protein leads to loss of caveolae. Mice with caveolin-1 deficiency have dysfunctional blood vessels, but whether absence of cavin-1 similarly leads to vascular dysfunction is not known. Here we addressed this hypothesi
Multiple sclerosis (MS) is an immune-mediated demyelinating and neurodegenerative disease of the central nervous system (CNS). Neuroinflammatory processes in MS are believed to lead to damage and leakage in the blood-brain barrier that protects the CNS and regulates the trafficking of soluble mediators and leukocytes. MS is thought to be triggered in genetically susceptible individuals following e
BACQUIN, MARI, Theseus de Cologne, édition partielle d’une chanson de geste du XIVe siècle. Études romanes de Lund, 81, 355 pages. Written in French. Monograph. Theseus de Cologne is a French romance from the fourteenth century written by an anonymous author. This voluminous work contains more than 26,000 lines. The text of the romance is preserved in three manuscripts from the fifteenth century,
Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (M
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial. For this study, treatment efficacy was determined among 145 trial patients with morphological forms of acute myeloid leukemia as defined by the French-American-British classification. Leukemia-free survival was strongly i
Different designs of flat-tube heat exchangers with plain fins have been evaluated theoretically in a parameter study in order to evaluate their performance potential in indirectly cooled display cabinets. Two different types of flat-tube heat exchangers were considered; one with serpentine fins and one with continuous plate fins. Both flat-tube heat exchanger types were adapted to the laminar flo
The aim of this study is to review recent data on dietary fiber (DF) and the glycemic index (GI), with special focus on studies from the Nordic countries regarding cardiometabolic risk factors, type 2 diabetes, cardiovascular disease, cancer, and total mortality. In this study, recent guidelines and scientific background papers or updates on older reports on DF and GI published between 2000 and 20
Background: Little is known about the causes of thyroid cancer, but insulin-like growth factor-I (IGF-I) might play an important role in its development due to its mitogenic and antiapoptotic properties. Methods: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Pr
The present study investigates the nature of the link between the staphylococcal enterotoxin A (SEA) gene and the lifecycle of Siphoviridae bacteriophages, including the origin of strain variation regarding SEA production after prophage induction. Five strains representing three different genetic lines of the sea region were studied under optimal and prophage-induced growth conditions and the Siph
Abstract Objective. To examine pregnancy outcomes in relation to different categories of glucose tolerance during pregnancy. Design. Prospective observational cohort study. Setting. Patient recruitment and data collection were performed in four delivery departments in southern Sweden. Population. Women delivering during 2003-2005; 306 with gestational diabetes mellitus, 744 with gestational impair
Despite being the most effective treatment for Parkinson's disease, L-DOPA causes a development of dyskinetic movements in the majority of treated patients. L-DOPA-induced dyskinesia is attributed to a dysregulated dopamine transmission within the basal ganglia, but serotonergic and noradrenergic systems are believed to play an important modulatory role. In this study, we have addressed the role o
We sampled small (0.03 to 3.3 km(2) surface area) forest lakes in southern Sweden during two summers to investigate how concentration of dissolved organic carbon (DOC) and lake size influence epilimnion depth (z(e)) and light conditions in the epilimnion. z(e) increased with increasing fetch (square root of lake area) but did not decrease with increasing DOC concentration. This suggests greater im
Our continuously changing global environment requires continuous and detailed monitoring for us to understand how ecosystems are structured and function in response to climatic changes. Understanding the arctic ecosystems is of particular importance (Oechel et al., 1997). Indeed, rather than in boreal and temperate regions, the forecasted climatic changes will be first and most pronounced in the A
Background: Attention deficit/hyperactivity disorder (AD/HD) and autism spectrum disorders (ASDs) are early-onset, but often life-time impairing, neurodevelopmental disorders. They are highly overlapping and seem to carry considerable risks of negative outcomes, psychiatrically and psychosocially. Childhood hyperactivity is a known risk factor for early-onset conduct disorder (CD), but details con
This work assesses the ability of transradial amputees to discriminate multi-site tactile stimuli in sensory discrimination tasks. It compares different sensory feedback modalities using an artificial hand prosthesis in: 1) a modality matched paradigm where pressure recorded on the five fingertips of the hand was fed back as pressure stimulation on five target points on the residual limb; and 2) a
Enterprise Risk Management (ERM) is a holistic, integrated approach to managing a company’s risks, in contrast to the so-called “silo-approach” prevalent in many firms in which risks are managed independently of each other. Yet for all the risk exposures that are brought under the corporate umbrella in an ERM initiative, it may be inadequate for addressing the firm’s aggregate risk in terms of the
The mechanism for a new appetite suppressor named thylakoids (membrane proteins derived from spinach leaves) was examined in vivo in pigs. Thylakoids inhibit the lipase/colipase hydrolysis of triacylglycerols (TG) in vitro and suppress food intake, decrease body weight gain and raise the circulating satiety hormone cholecystokinin (CCK) in rats but its mechanism in vivo remains unclear. We hypothe
Heavy neutron-rich nuclei have been populated through the relativistic fragmentation of a Pb-208(82) beam at E/A = 1 GeV on a 2.5 g/cm(2) thick Be target. The synthesised nuclei were selected and identified in-flight using the fragment separator at GSI. Approximately 300 ns after production, the selected nuclei were implanted in an similar to 8 mm thick perspex stopper, positioned at the centre of
This document describes a new concept for assessing capacitance based on a constant current pulse to the biosensor transducer. The biosensor has a working electrode that is coated with an insulating molecular layer including a ligand which forms an affinity surface. A sensor electrode is brought into contact with electrolyte solution, and the new measuring principle then involves steps where three
As the title largely illustrates, this study seeks to investigate, from a diplomatic-history and geostrategic perspective, the key developments in Anglo-Iranian relations during what may best be dubbed their “formative years,” ranging from 1907 to 1953. Having thus provided a glimpse into pre-twentieth-century Persian–British relations, it moves to analyze the division of Persia into two spheres o
