Sökresultat

To identify novel genes influencing blood pressure response to thiazide diuretic therapy for hypertension, we conducted genome-wide association meta-analyses of approximate to 1.1 million single-nucleotide polymorphisms in a combined sample of 424 European Americans with primary hypertension treated with hydrochlorothiazide from the Pharmacogenomic Evaluation of Antihypertensive Responses study (n

A macroscopically oriented double diamond inverse bicontinuous cubic phase (Q(II)(D)) of the lipid glycerol monooleate is reversibly converted into a gyroid phase (Q(II)(G)). The initial Q(II)(D) phase is prepared in the form of a film coating the inside of a capillary, deposited under flow, which produces a sample uniaxially oriented with a < 110 > axis parallel to the symmetry axis of the sample

Wheat flour and cane sugar were partially substituted (50 and 75%) by a mango-processing by-product (MPB) as an added-value food ingredient in muffins. Their sensory analysis, chemical composition, antioxidant activity and in vitro starch hydrolysis properties were studied. Sensory analysis showed statistically significant difference (p < 0.05) between control and muffins 75% MPB substituted level

Background Type 1 diabetes (T1D) is a cell-mediated autoimmune disease characterized by destruction of the pancreatic islet cells. The use of cryopreserved cells is preferable to the use of freshly isolated cells to monitor clinical trials to decrease assay and laboratory variability. Methods The T-Cell Workshop Committee of the Immunology of Diabetes Society compared two widely accepted T-cell fr

This paper explores two approaches to information processing and learning in societal safety efforts: (1) stressing specifics and (2) aiming at generalities. It discusses how the two approaches are related to each other and to high-level efforts to achieve societal safety. As background, this paper briefly explores the concept of generic capability – what is it? How is it to be understood? How can

Enantioselective hydrogenation of tiglic acid effected by diastereomers of the general formula [(μ-H)2Ru3(μ3-S)(CO)7(μ-P-P*)] (P-P* = chiral Walphos diphosphine ligand) strongly supports catalysis by intact Ru3 clusters. A catalytic mechanism involving Ru3 clusters has been established by DFT calculations.

Atherosclerosis is a systemic condition that eventually evolves into vulnerable plaques and cardiovascular events. Pathology studies reveal that rupture-prone atherosclerotic plaques have a distinct morphology, namely a thin, inflamed fibrous cap covering a large lipidic and necrotic core. With the fast development of imaging techniques in the last decades, detecting vulnerable plaques thereby ide

This paper examines the relationship between income taxes and the decision to become self-employed using data from Sweden. By making it possible to track a large number of individuals over extended time periods and across a number of tax rate changes while controlling for important additional determinants, available tax-return information from Sweden allows for statistical estimation of the influe

The Satisfaction With Life Scale (SWLS) is a global measure of life satisfaction (LS). The objective of this study was to evaluate the psychometric properties (data completeness, scaling assumptions, targeting and reliability) of the SWLS in a sample of people with Parkinson's disease (PD).

Recoil-induced rotational excitation accompanying photoionization has been measured for the X, A, and B states of N-2(+) and CO+ over a range of photon energies from 60 to 900 eV. The mean recoil excitation increases linearly with the kinetic energy of the photoelectron, with slopes ranging from 0.73 x 10(-5) to 1.40 x 10(-5). These slopes are generally (but not completely) in accord with a simple

This work describes a new diffusion MR framework for imaging and modeling of microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of two parts: encoding and modeling. First we propose q-space trajectory encoding, which uses time-varying gradients to probe a trajectory in q-space, in contrast to traditional pulsed field gradient sequences that attempt to probe a

We sought to assess the impact of amino-acid (18)F-fluoro-ethyl-tyrosine (FET) positron emission tomography (PET) on the volumetric target definition for radiation therapy of high-grade glioma versus the current standard using MRI alone. Specifically, we investigated the influence of tumor grade, MR-defined tumor volume, and the extent of surgical resection on PET positivity.

The effect of atomic oxygen adsorption on the structure and electronic properties of monolayer graphite (MG or graphene) grown on Pt(111) and Ir(111) has been studied using X-ray photoelectron spectroscopy, near-edge X-ray absorption fine structure spectroscopy, and scanning tunneling microscopy. For comparison, the adsorption of atomic oxygen on highly oriented pyrolytic graphite has been studied

Metastatic disease is responsible for most cancer deaths, and hematogenous spread through circulating tumor cells (CTC) is a prerequisite for tumor dissemination. CTCs may undergo epithelial–mesenchymal transition where many epithelial cell characteristics are lost. Therefore, CTC isolation systems relying on epithelial cell markers are at risk of losing important subpopulations of cells. Here, a

The 116m deep Fararp-1 core drilled in the Vomb Trough in southernmost Sweden is dated by integrated terrestrial and marine palynostratigraphy. The lower part of the succession (ca 84 m) encompasses uppermost Jurassic to lowermost Cretaceous (uppermost Tithonian to Valanginian) strata. An unconformity separates the Valanginian strata from an overlying ca 1 m thick interval of upper Albian to Cenom

Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area i

During the process of biomass gasification tars are formed which exit the gasifier in vapor phase. Tar condensation creates problems like fouling and plugging of after-treatment, conversion and end-use equipment. Gasification tars consist mainly of Polycyclic Aromatic Hydrocarbons (PAHs). Former research has shown the possibilities and difficulties of tar conversion by partial combustion. Basic st