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IMPORTANCE: Key information is often omitted from pediatric randomized controlled trial (RCT) protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimize participants' anxiety and pain. These deficiencies impair the planning and implementation of potent

IMPORTANCE: Randomized controlled trials (RCTs) in children and adolescents provide evidence for patients, families, researchers, clinicians, regulators, funders, policymakers, and other interest holders to inform decisions about health care interventions and improve outcomes for young patients and their families. To critically evaluate, interpret, and apply trial results, readers require access t

Randomised controlled trial (RCT) protocols contain essential details needed to understand and evaluate the trial's planned aims, design, data collection methods, monitoring, data analysis, and participants' safety. However, key information is often omitted from paediatric RCT protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmenta

The saturation of the IJTAG concept and its approval as the IEEE 1687 standard in 2014 has generated a wave of research activities and created demand for a set of appropriate and challenging benchmarks. This paper presents such a set developed by an industrial and academic consortium and constructed in a way that facilitates objective comparison of experimental results across research groups as we

BACKGROUND: TF (transcription factor) Prdm16 (positive regulatory domain-containing protein 16) regulates hematopoietic and neuronal stem cell homeostasis, adipose differentiation, and cardiac development. Its role in the circulatory system extends beyond the heart, as Prdm16 loss in arterial endothelial cells (ECs) impairs arterial reperfusion of ischemic mouse limbs due to endothelial dysfunctio

This book provides a critique of David Harvey's theory of land rent and his replacement of Marx's concept of absolute rent with class-monopoly rent, arguing that this shift inadequately addresses crucial theoretical and empirical problems in urban economic geography today. The alternative introduced links land rent to fluctuations in profit rates rather than monopoly pricing. Land Rent, Capital, R

The clustering of certain proteins into oligomers and fibrils, known as amyloids, underlies the pathology of diseases such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes. These processes are counteracted by the cellular protein quality control system, which includes molecular chaperones that interact with disease-associated proteins. One such chaperone is DNAJB6b, which has gaine

Friendship is a common and complex social bond. Among friendship practices yet to be fully understood are group- versus dyadic-oriented friendship styles, or whether people socialize with one versus multiple friends at a time. We report two studies comparing friendship styles and relational mobility among 1674 young adults (18–35 years old) in Japan and the United Kingdom. Respondents from both co

Occupational exposure to cancer-causing agents is a major, yet preventable, contributor to cancer in Europe and globally. In the European Union (EU), cancer is responsible for nearly half of all work-related deaths, underscoring the critical need for prevention measures. Effective strategies typically involve regulatory and workplace measures aimed at reducing or eliminating exposure risks. Raisin

The European Code Against Cancer (ECAC) provides evidence-based recommendations to help individuals reduce their cancer risk. For the 5th edition (ECAC5), recommendations on ultraviolet radiation (UVR) and indoor radon exposures were updated, and complementary recommendations for policymakers were introduced. UVR and radon are classified as carcinogenic to humans (group 1 carcinogens) in the Inter

Investigates memory initiatives in three of the world’s hardest to solve conflicts and how they can be invested with more constructive dynamics Agonistic memory work as a framework for conflict transformation In-depth case studies from Colombia, Israel-Palestine, and Northern Ireland Careful historical tracing of memory politics in zones of protracted conflict Agonistic memory dialogues a