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It has been argued that survival bias may distort results in Mendelian randomization studies in older populations. Through simulations of a simple causal structure we investigate the degree to which instrumental variable (IV)-estimators may become biased in the context of exposures that affect survival. We observed that selecting on survival decreased instrument strength and, for exposures with di

https://www.lupop.lu.se/article/survival-bias-mendelian-randomization-studies-threat-causal-inference - 2025-10-05

At present, we know relatively little about priorities and problems with topics that older adults experience when completing different examinations in longitudinal population-based studies. To examine these topics, research must be adapted to investigate the meanings, motivations, and interpretations of the individual participants themselves. New publication in BMC Geriatrics.Read more here.

https://www.lupop.lu.se/article/was-it-worth-it-older-adults-experiences-participating-population-based-cohort-study-focus-group - 2025-10-05

To compare the risk and severity of prostate cancer between men achieving fatherhood by assisted reproduction and men conceiving naturally. New publication in thebmj.Read more here.

https://www.lupop.lu.se/article/risk-prostate-cancer-men-fathering-through-assisted-reproduction-nationwide-population-based - 2025-10-05

Breast cancer is the most common cancer and the leading cause of cancer-related death in females, with a large societal and economic impact. Decisions regarding its treatment are largely affected by the categorization into different subtypes with hormone receptor status and HER2 status being the most important predictive factors. New publication in SAGE Journals.Read more here.

https://www.lupop.lu.se/article/cancer-registries-guardians-breast-cancer-biomarker-information-systematic-review - 2025-10-05

The FMA is a validated 10-item patient-centered outcome measure that investigates satisfaction in performing common mobility-related activities of daily living. The UDS includes variables related to age, diagnosis, and type of device used, as well as health, participation, and environmental factors. New publication in Archives of Physical Medicine and Rehabilitation.Read more here.

https://www.lupop.lu.se/article/development-and-implementation-wheelchair-outcomes-registry - 2025-10-05

In married individuals, resident children are associated with a reduction in basal risk for AUD which is stronger in mothers than fathers and with younger v. older children. This effect is also evident during high-risk periods. In mothers, our results are consistent with a largely causal effect. New publication in Psychological Medicine.Read more here.

https://www.lupop.lu.se/article/impact-parenthood-risk-registration-alcohol-use-disorder-married-individuals-swedish-population - 2025-10-05

Both clinical trials and registries are essential and complementary research methods and the strengths and weaknesses of each need to be recognized. The specific characteristics of registry research deserve to be acknowledged and safeguarded in the regulations governing clinical investigations with medical devices. New publication in SAGE Journals.Read more here

https://www.lupop.lu.se/article/research-methodology-and-practical-issues-relating-conduct-medical-device-registry - 2025-10-05

Employing Norwegian register data in a between-group comparison illustrates that register data would be particularly useful for several key areas of an RCT, including as a source of pilot data, to expand the range of variables on which between-group equivalence can be demonstrated, to increase the length of the observation period, to expand the number and type of individual-level outcomes availabl

https://www.lupop.lu.se/article/potential-incorporating-administrative-register-data-randomized-experiments - 2025-10-05

New publication in Web of Science.Read more here.

https://www.lupop.lu.se/article/gdpr-and-research-exemption-considerations-necessary-safeguards-research-biobanks-0 - 2025-10-05

The National Cancer Database (NCDB) continues to evolve to improve the care of the cancer patient. Over the last 30 years, the NCDB has compiled nearly 40 million patient records submitted by over 1500 hospitals across the country. Addressing new challenges, the NCDB is transitioning to ensure data flow is more timely and data collection more efficient. New publication in Seminars in Radiation Onc

https://www.lupop.lu.se/article/national-cancer-database-past-present-and-future-cancer-registry-and-its-efforts-improve-quality - 2025-10-05

Social position is known to play a role in the quality of ageing, notably through the stimulation/dysregulation of key physiological systems in response to external stresses. Using data from one wave of Understanding Society including 9088 participants, we defined, as an extension of the allostatic load, a synthetic Biological Health Score (BHS) capturing the wear-and-tear of four physiological sy

https://www.lupop.lu.se/article/early-life-inequalities-and-biological-ageing-multisystem-biological-health-score-approach - 2025-10-05

FFG-Academy Webinar on how to identify ethical issues at the proposal phase and how to address them properly in the project implementation phase Read more here.

https://www.lupop.lu.se/article/getting-ready-research-ethics-and-research-integrity-horizon-2020 - 2025-10-05

There are no currently agreed upon international standards for reporting of pediatric deceased organ donation activity. This leads to difficulty in comparisons between jurisdictions for both researchers and policy stakeholders. The goal of this project was to develop and test a standardized registry for pediatric deceased donation activity. New publication in Pediatric Transplantation.Read more he

https://www.lupop.lu.se/article/development-multinational-registry-pediatric-deceased-organ-donation-activity - 2025-10-05

Statistik missbrukas i syfte att driva opinion mot klimatmarscherna, skriver en rad svenska forskare i en replik till Bjart Holtsmark från Norges statistiska centralbyrå. Hela artikeln

https://www.lupop.lu.se/article/klimatkrisens-effekter-ar-fakta-inte-asikter - 2025-10-05

The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability coefficients. New publicat

https://www.lupop.lu.se/article/commonly-used-estimates-genetic-contribution-disease-are-subject-same-fallacies-bad-luck-estimates - 2025-10-05

Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network–Breast (SCAN-B) project (ClinicalTrials.gov ID:NCT02306096). New publ

https://www.lupop.lu.se/article/whole-genome-sequencing-triple-negative-breast-cancers-population-based-clinical-study - 2025-10-05

A principle goal of research in Oncology is to determine the optimal treatment for our patients. This often takes the form of comparing 2 existing therapies to one another to determine which is superior, or to introduce a new therapy and determine if it is superior or noninferior to the existing standard of care. New publication in Seminars in Radiation Oncology

https://www.lupop.lu.se/article/population-based-observational-studies-oncology-proceed-caution - 2025-10-05

ICD codes are a highly reliable indicator of tumor location when the specific location code is entered in the EHR. However, non-specific side of colon ICD codes are present for a sizable minority of patients, and structured data alone may not be adequate to support testing of some research hypotheses. New publication in BMC Medical Research Methodology

https://www.lupop.lu.se/article/validation-diagnosis-codes-identify-side-colon-electronic-health-record-registry - 2025-10-05

This two-week course is divided into two separate course weeks. The course will be arranged as a retreat somewhere in Sweden. Travel costs and accommodation will be covered in relation to the educational activities. The target group is doctoral students (and those who have recently completed their doctoral education) involved in register-based research within their research training. Eligible appl

https://www.lupop.lu.se/article/key-concepts-and-principles-design-and-critical-interpretation-nordic-register-based-studies-0 - 2025-10-05

In conclusion, umbrella reviews provide a comprehensive overview of a specific research topic and are very helpful tools to evaluate the certainty of evidence. These systematic overviews are helpful for the translation of research findings into recommendations, and also for identifying new research directions. New publication in European Journal of Epidemiology

https://www.lupop.lu.se/article/critical-reflection-grading-certainty-evidence-umbrella-reviews - 2025-10-05