The Case for Case–Cohort: An Applied Epidemiologist’s Guide to Reframing Case–Cohort Studies to Improve Usability and Flexibility
When research questions require the use of precious samples, expensive assays or equipment, or labor-intensive data collection or analysis, nested case–control or case–cohort sampling of observational cohort study participants can often reduce costs. These study designs have similar statistical precision for addressing a singular research question, but case–cohort studies have broader efficiency a