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Chromosomal aneuploidy, that is, numerical chromosome aberrations, is one of the molecular hallmarks of cancer. However, when neoplasms are studied with sequencing- and array-based approaches, chromosome numbers and ploidy states are typically inferred from bulk DNA data. Furthermore, published molecular estimates of neoplasia-associated aneuploidy often also include genomic imbalances resulting f
Schlieren imaging has been established as a reliable optical measurement technique for flame visualizations and retrieval of laminar burning velocity information. However, it is off limited capability and adaptability due to the optical configuration of a conventional Schlieren setup. In this regard, background oriented Schlieren (BOS) provides a unique opportunity to quantitatively characterize d
The TFM-DYN model represents a significant advancement from static flow accumulation estimations into dynamic hydrological modeling (Nilsson et al., 2021). It incorporates variable precipitation in time and space as input together with high-resolution topography and includes functions for friction and infiltration to produce results such as water depths, flow velocity, inundated areas, flow pathwa
This open access book explores how to build a gender-just peace in which women’s political citizenship is foregrounded through a case study of Northern Ireland. It addresses the role that civil society can play in peacebuilding and in political life in deeply divided transitional societies. It specifically focuses on women’s groups, and, as such, studies what grassroots peacebuilding across an eth
We present a protocol for the Boolean matrix product of two n×n Boolean matrices on the congested clique designed for the situation when the rows of the first matrix or the columns of the second matrix are highly clustered in the space {0,1}n. With high probability (w.h.p), it uses O~Mn+1 rounds on the congested clique with n nodes, where M is the minimum of the cost of a minimum spanning tree (MS
Semi-arid ecosystems, common across the Australian continent, strongly influence the inter-annual variability and trend in the global terrestrial net carbon sink. Here we explore the future Australian terrestrial carbon cycle using the CMIP6 ensemble, and the dynamic global vegetation model LPJ-GUESS. Uncertainty in Australia's carbon storage in vegetation ranged between 6 and 49 PgC at the end of
Background & objectives: Endoscopy is the current gold standard for evaluation of disease activity in ulcerative colitis. The Mayo Endoscopic Subscore (MES) is commonly used for quantifying disease activity, but it has several weaknesses. Numerous new endoscopic indices have been developed but none of these have been widely implemented, likely due to limited feasibility. The primary objective
Background: Family-centered rounds (FCR) reduce the risk of psychological comorbidities of family members and improve the quality of communication between providers and families. Materials and methods: We conducted a pilot quality improvement study analyzing family perceptions of virtual FCR. Family members of previously admitted cardiac ICU patients who participated in at least one session of vir
This paper reviews research on child L2 French (cL2) published since 2000 with a focus on research areas and methodology in a broad sense. The aim of the review is to identify methodological trends in the research, to exemplify, and to provide a discussion of prominent features. The review shows that research on cL2 French has mainly focused on the acquisition of morphosyntax based on oral product
The article analyzes power structures and relations in the Soviet Union in the mid-1960s, i.e., in the first years of Leonid Brezhnev's rule. It shows how Brezhnev limited the control mechanisms of power introduced by Nikita Khrushchev in order to consolidate his own position. The analysis contributes to a better understanding of the failure of Khrushchev's "reform communism" and the construction In October 1964, the leader of the Communist Party of the Soviet Union (CPSU), Nikita Khrushchev, was abruptly removed from office by the ruling CPSU Presidium. His successor, Leonid Brezhnev, had to solidify his own political position for some time afterward. Rumors soon circulated that Brezhnev might be removed himself by younger members of the ruling elite, particularly Aleksandr Shelepin and V
Commercial small-scale fisheries along the Baltic Sea coasts have declined over the years although these fisheries are viewed as important for coastal development and food security at the local, national, and EU levels. The viability and future of small-scale fisheries are severely challenged by problems caused by grey seals. The conflict, occurring between Baltic Sea coastal fisheries and conserv
This work aimed to investigate structurally defined biobased polymers as non-leachable and non-toxic UV blockers for sunscreen applications. Two dicarboxylate monomers were synthesized using two lignin-based monomeric aromatic compounds, vanillin and 4-hydroxybenzaldehyde. These two monomers were then polymerized together with linear aliphatic diols of varying lengths to produce UV-active polyeste
Eye tracking technology has become increasingly prevalent in scientific research, offering unique insights into oculomotor and cognitive processes. The present article explores the relationship between scientific theory, the research question, and the use of eye-tracking technology. It aims to guide readers in determining if eye tracking is suitable for their studies and how to formulate relevant
Symbiotic relationships between eukaryotes and prokaryotes played pivotal roles in the evolution of life and drove the emergence of specialized symbiotic structures in animals, plants and fungi. The host-evolved symbiotic structures of microbial eukaryotes – the vast majority of such hosts in nature – remain largely unstudied. Here we describe highly structured symbiosomes within three free-living
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture of early eukaryotic cellular complexity requires provision of analytical resources and
The present paper explores legal issues concerning connected objects used for health or health-related purposes and their corresponding usage of health and health-related data. It focuses on a patient/healthcare-user-centred perspective and researches the EU legal framework for health data and health-related data. Arguing that the legal framework, as recently complemented with the European Health
