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Background: Glatiramer acetate (GA) is a well-established treatment option for patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis (MS) with few side effects. The double transgenic mouse model spontaneous opticospinal encephalomyelitis (OSE), based on recombinant myelin oligodendrocyte glycoprotein35-55 reactive T and B cells, mimicks features of chronic inflammat
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) are antibody mediated CNS disorders mostly affecting the optic nerve and spinal cord with potential severe impact on the visual pathway. Here, we investigated inflammation and degeneration of the visual system in a spontaneous encephalomyelitis animal model. We used double-tra
Low-grade superficial connective tumors are a heterogeneous group of benign/reactive, intermediate—locally aggressive and intermediate—rarely metastasizing lesions arising in skin and subcutaneous/superficial soft tissues. The most common targets for fine needle aspiration (FNA) in this group of lesions are schwannomas, desmoids, and “pseudosarcomatous lesions” such as nodular fasciitis. Experienc
Objective: Progressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration with inadequate effectiveness of medications used so far. We now investigated effects of iron on microglia and used the previously identified neuroprotective antipsychotic clozapine in vitro and in chronic experimenta
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo a
The main use of splenic fine needle aspirations (FNAs) is to diagnose primary tumors or tumorlike lesions including metastases and to assess splenic involvement of some hematopathological disorders. This chapter deals with disorders likely to be encountered in FNAs from the spleen in everyday practice.
In patch testing, a standardized manner of testing and of patch test reading is essential. In this chapter, the basic aspects of these issues are discussed, as well as thoughts on when patch testing should be probably, with what to patch test, especially considering the baseline series, and pitfalls when patch test reading.
Early cathedrals in Lund and DalbyThe aim of the article is to present and critically re-evaluate the written end material sources concerning the early cathedrals of Lund and Dalby in Scania, former medieval Denmark and now part of Sweden. The main questions are where and when did exist cathedrals in Scania in the 11th Century, how were their architecture, how can they be dated, and why were there
Was bedeutet es als Christ in einer Gesellschaft nicht zur Mehrheit zu gehören? Welche Aufgaben erwachsen hieraus, und wie gewinnt das Christentum seine gesellschaftliche Stimme? Eingeleitet und herausgegeben von Esther-Maria Guggenmos zeigen Beiträge von Alumni des KAAD durch Fallstudien aus Kenia, Vietnam, Thailand, Georgien, China, den Philippinen, dem Iran und zu den indigenen Völkern, welche
Depiction of sinusoidal displacement in nanocrystal superlattices through a minimum of geometric shapes and contrasting colors. This cover pays homage to the Bauhaus movement, celebrating human-made craftsmanship, clarity, and accessibility in scientific design, and remains faithful to its fundamental principle: less is more.
Background: Cranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a therapeutic agent protecting hippocampal neurons would be beneficial. Fingolimod (FTY720), a sphingosine-1-phosphate receptor modulator approved for mult
Environmental triggers acting at the intestinal barrier are thought to contribute to the initiation of autoimmune disorders. The transforming growth factor beta inhibitor Smad7 determines the phenotype of CD4+ T cells. We hypothesized that Smad7 in intestinal CD4+ T cells controls initiation of opticospinal encephalomyelitis (OSE), a murine model of multiple sclerosis (MS), depending on the presen
