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Nearly 40 % of individuals will be diagnosed with cancer in their lifetime, translating to an estimated 20 million new cases annually. Despite remarkable therapeutic advances, only 15–20 % of patients achieve durable responses to immunotherapy, and the high cost of treatment (illustrated by immune checkpoint inhibitors like pembrolizumab and nivolumab, totaling roughly $191,000 per year) remains a

Phytoplankton employ a wide variety of defenses to reduce mortality from zooplankton grazing. Many such defenses are inducible, that is, they are upregulated in the event of increased predation. Thus, theory predicts that they should come at a cost to the organism. When exposed to predatory cues from a copepod predator, the diatom Pseudo-nitzschia seriata upregulates the production of the neurotox

Foraging in landfills enhances the probability of acquiring antimicrobial resistance (AMR) in wildlife and increases exposure to pollutants like metal(loid)s, pharmaceuticals and caffeine. Exposure to metal(loid)s in the environment may cause selective pressure on bacteria, inducing metal resistance genes that drive antimicrobial resistance genes (ARGs) through co-resistance and cross-resistance m

This meta-review evaluated the possibility of more specified recommendations in antibiotic treatment through a narrowed focus on facial trauma. The aim was to analyze the effect of different regimens of antibiotic in treatment of skeletal trauma to the face. The knowledge mapping was based on existing systematic reviews (SRs) on trials specified in a PICO: Participants (P): Adults and children, di

Background: Studies on long-term exposure to air pollution at high levels suggest an association with increased risk of metabolic syndrome (MetS). We aimed to study this relationship at very low levels, less well-studied, yet of public health importance. Methods: The Swedish CArdioPulmonary bioImage Study (SCAPIS) consists of randomly selected subjects aged 50–64 years from six large cities in Swe

The present work presents extinction strain rates in both premixed and non-premixed cases for n-heptane flames, simulated with different transport formulations and a range of Lennard-Jones parameter sets. Although mixture-average and multi-component transport formulations give similar results, the inclusion of thermal diffusion has a larger impact. Thermal diffusion creates an accumulation of n-he

In the scholarly literature on the geography of transitions, the global innovation systems framework has been used to understand how system resources—such as knowledge, legitimacy, markets, and financial investments—are linked across various geographical scales, contributing to the emergence and performance of an innovation system within a distinct technological field. In this paper, we further de

A global larger foraminiferal turnover (LFT), first identified in the Pyrenees in 1960, occurred around the Paleocene-Eocene boundary. It is characterized by the replacement of Paleocene assemblages dominated by Glomalveolina and Lockhartia (west and east Tethys, respectively), with others typified by Eocene Alveolina and Nummulites. Its relationship with the Paleocene-Eocene Thermal Maximum (PETM

Flame spread through ventilation cavities in timber facades is a serious fire safety concern in tall buildings. In this study, flame behaviour inside a particleboard cavity, resembling the ventilation cavity in a façade system, was investigated. Experiments were conducted with particleboard on one side and an inert panel on the other, across six cavity widths ranging from 10 cm to 25 cm. Variation

Study Region: The Juzhang River Basin in Hubei, China. Study Focus: Precipitation is crucial information in hydrological modelling, and its uncertainty significantly affects the simulation performance. This study constructs a decision tree-based gridded fusion model to integrate multiple precipitation products, generating multi-source fused precipitation products (MSFPPs). The mesoscale hydrologic

Over the past century, Syria and the broader Middle East and North Africa (MENA) region have undergone profound demographic and economic transformations, yet they remain marked by deep regional, ethnic, and gender-based inequalities. These divisions have shaped development trajectories and contributed to social fragmentation, while successive waves of migration carried these dynamics abroad, from

Previous treatment studies have suggested an antidepressant effect of adjunctive probiotics, but more high-quality randomized controlled trials (RCTs) are needed before clinical implementation. The mechanisms underlying putative antidepressant effects of probiotics are not understood, but one possibility is that they are mediated via short-chain fatty acids (SCFAs) − neuroactive bacterial metaboli

We employ a qualitative approach to explore whether and how the use of performance measurement systems differs between public and private providers in Swedish and Finnish primary care, from the perspective of primary care centre managers. The two settings are similar in terms of decentralised healthcare systems but differ in terms of organisation of primary care and governance principles for publi

This paper reports on the challenges of handling menstrual waste in informal settlements in Kisumu, Kenya, and the emerging conflicts between reducing the use of these ‘complicated plastics’ and ensuring human health and dignity. To investigate these interconnections, we draw on a survey conducted among sanitation workers conducting manual pit emptying. We then conducted a knowledge co-production

Objectives: This paper analyzes the educational content of the MinSmerte (MyPain) app, designed to educate patients on postoperative pain management after ambulatory surgery. It examines the complexity of instructional videos, investigating how these relate to the legitimacy claims constructed by educators – defined as assertions about the value of the information based on its relevance, authority

Glycosaminoglycans are structurally diverse polysaccharides that play essential roles in cellular signaling, extracellular matrix organization, and disease progression. Despite their biological importance, the mechanisms of GAG biosynthesis remain not fully understood. This thesis aims to advance mechanistic insight into the biosynthetic machinery and to develop chemical tools and inhibitors targe

The cosmogenic radionuclide 36Cl is a valuable tracer for studying Earth system processes, solar variability and geomagnetic field changes. These applications rely on a comprehensive understanding of 36Cl transport and deposition processes, which are still poorly studied. In this study, we apply a state-of-the-art climate model ECHAM6.3-HAM2.3 to investigate the source distribution and deposition