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Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely allows for recovery from metabolic impairment, it remains unknown whether long-term hypothalamic inflammation induced by obesogenic diets is a reversible process. In this study, we aimed at determining sex specificity of hypothalamic neuroinflammation and gliosis in mice fed a f
PURPOSE:Among available tumour necrosis factor inhibitors (TNF-inhibitors) only etanercept is approved for treatment of children with polyarticular course juvenile arthritis. Nevertheless also infliximab and adalimumab are used in selected cases, especially in patients having failed on etanercept.The objective was to evaluate adherence to therapy (a combined measure of efficacy and side effects as
We propose a simple approach to treatment effect estimation in panel data that is valid when the number of time periods is small and the parallel trends condition is violated due to the presence of interactive fixed effects. The procedure allows the covariates to be affected by treatment and enables separation of the part of the estimated treatment effect that is due to the covariates from the par
Researchers use area of interest (AOI) analyses to interpret eye-tracking data. This article addresses four key aspects of AOI use: 1) how to report AOIs to support replicable analyses, 2) how to interpret AOI-related statistics, 3) methods for generating both static and dynamic AOIs, and 4) recent developments and future directions in AOI use. The article underscores the importance of aligning AO
Inflammation and infection remain unmet challenges in wounds of various etiologies, delaying healing, impacting quality of life, and increasing healthcare costs. The thrombin-derived C-terminal peptide TCP-25 has demonstrated dual anti-inflammatory and antibacterial activities in animal wound infection models, thereby promoting healing, highlighting its therapeutic potential as a wound treatment.
China plans expanding 49.5 million hectares of new forests by 2050 to strengthen carbon sequestration. However, estimates of the carbon benefits from this expansion rarely consider the effect of 'forest edge', where tree mortality increases under intensified stress from wind, drought, pests, and fire. Here we show that proximity to forest edges substantially reduces biomass carbon storage, and dev
Increasing drought frequency and intensity affect biophysical functions of natural ecosystems. In tropical semi-arid savannas, while immediate drought effects are well-studied, the drought legacy effects on vegetation composition and associated ecosystem functions remain unclear. We used data of vegetation composition, net ecosystem CO 2 exchange, surface albedo and evapotranspiration (ET) in 201
Over-reliance in high-risk industries on prescriptive emergency procedures and the capacity of high-fidelity simulation has initiated the search for new steps for training for unexpected and escalating situations. This chapter outlines a theoretical framework describing the adaptive and flexible competencies that add up to an organisation’s resilience in escalating situations. To make the framewor
