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Purpose: Breast cancer is one of the leading causes of cancer-related deaths among women, and digital mammography plays a key role in screening and early detection. The radiation dose on mammographic exams directly influences image quality and radiologists’ performance. We evaluate the impact of an image restoration pipeline—designed to simulate higher dose acquisitions—on the detectability of mic

Purpose: The purpose is to retrospectively investigate how the addition of prior and concurrent mammograms affects wide-angle digital breast tomosynthesis (DBT) screening false-positive recall rates, malignancy scoring, and recall agreement. Approach: A total of 200 cases were selected from the Malmö Breast Tomosynthesis Screening Trial. They consist of 150 recalled cases [30 true positives (TPs),

Purpose: The purposes are to evaluate the change in mammographic density within individuals across screening rounds using automatic density software, to evaluate whether a change in breast density is associated with a future breast cancer diagnosis, and to provide insight into breast density evolution. Approach: Mammographic breast density was analyzed in women screened in Malmö, Sweden, between 2

The transition to sustainable energy is crucial for modern society, and Reverse Electrodialysis (RED) offers a promising method for harvesting energy from salinity gradients. However, large-scale deployment of RED is constrained by efficiency limitations and the high cost of ion exchange membranes. This study focuses on the development of novel asymmetric cation exchange membranes (CEMs) based on

Synucleinopathies and tauopathies are neurodegenerative disorders characterized by the pathological accumulation of α-synuclein (α-syn) and tau proteins, respectively. These disorders are traditionally managed with symptomatic treatments without addressing the underlying pathologies. Recent advancements in passive immunotherapies, notably the FDA approval of the amyloid-beta (Aβ)-targeting antibod

Monitoring antimicrobial resistance genes (ARGs) in wastewater influents (pre-treatment) and effluents (post-treatment) provides insights into community-level circulation, potential amplification during treatment, and risks associated with gene release into surface waters. Pollutants such as antibiotic residues and microplastics (MPs) may influence ARG dynamics, highlighting the need to assess the

Introduction: Tpeak-Tend interval (Tpe) is considered to be an ECG reflection of the dispersion of repolarization (DOR), and as such has been proposed as a predictor of arrhythmias. In ischemia, robustness of the Tpe-DOR relationship may suffer from variability of the myocardium at risk (MaR) area. In the present study, we evaluated the contribution of DOR and MaR to single‑lead and multi‑lead Tpe

Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying the uptake of α-syn fibrils remain unclear. In this work, we identified FAM171A2 as a PD risk gene that affects α-syn aggregation. Overexpressing FAM171A2 promotes α-syn fibril endocytosis and exacerbates the spread and

Male childlessness in late adulthood is increasingly prevalent in rural China, indicating a critical need to understand the factors contributing to childlessness among rural men—an often-overlooked group in gerontological and childlessness research. While existing studies have explored individual-level predictors of childlessness over the life course and the implications of broader societal condit

Introduction: Alcohol use has significant health implications, yet the association between alcohol use and respiratory symptoms remains relatively understudied. This study examines the prevalence of hazardous alcohol use and its associations with breathlessness, chronic cough, and health-related quality of life (HRQoL) and whether these associations with chronic airway limitation (CAL) differ by a

This article applies a conceptual framework based on multilevel theories of gender inequality to examine individual-level food insecurity (FI) outcomes in the League of Arab States (LAS). We conceptualize FI as an embodied waypoint on a discriminatory cycle incorporating material and cultural practices that function at macro-, situational-, and individual-levels. Using data drawn from the Gallup W

Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa

In 1972 Hajnal and Kertész published a paper proving that the Axiom of Choice is equivalent to the assertion that a groupoid structure can be defined on every set. This thesis aims to provide the necessary background needed for this proof. In the first part basic concepts in set theory such as the Well-Ordering Theorem are derived. This culminates in a lemma by Hartogs (1915) in which it is shown,

This paper provides a critical analysis of Harry G. Frankfurt's seminal theory of bullshit, as outlined in his works "On Bullshit" and "On Truth." The thesis establishes Frankfurt's central argument that the defining characteristic of the bullshitter is an indifference to the truth, a quality that fundamentally distinguishes the bullshitter from the liar, who actively e

Laminins are basement membrane components that regulate a plethora of biological processes. Despite decades of research, the exact roles of laminins in different tissues and in organogenesis remain to be elucidated. Here, we investigated the function of laminin γ1 chain in heart, lung and other tissues by generating a mouse that lacks laminin γ1 in cells expressing SM22α (Tagln) (LMγ1 flox/SM22α C

Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp

Background: Signet ring cell (SRC) colorectal cancer is strongly associated with peritoneal metastases (PM), but the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remains uncertain due to poor prognosis. This study aimed to analyse the prognostic impact of SRCs, assess clinical characteristics, and evaluate the risk of open-close laparotomy. Methods: Thi

Aims: Experimental evidence suggests an important role for sphingosine-1-phosphate (S1P) and its generating enzymes sphingosine kinase 1/2 (SphK1/2) in obesity. We and others have shown that plasma S1P levels are elevated in obese mice and humans. Preclinical studies suggest that genetic SphK2 ablation in mice protects from age- and diet-induced obesity and metabolic dysfunction. We aimed at inves

Background: The coronavirus disease-2019 (COVID-19) pandemic posed pronounced challenges in the care of lung transplant (LTx) recipients. Global variations in containment strategies and the introduction of messenger ribonucleic acid (mRNA) vaccines have sparked extensive debate in both scientific and public arenas. Methods: This retrospective study compared outcomes among LTx recipients in Denmark

Biotechnology is a rapidly progressive field, currently transforming agriculture, healthcare, and life sciences. This rapid development comes with serious legal and ethical challenges as well as risks for human security and health. NATO has prioritized biotechnology and human enhancement technologies for defense, focusing on legitimate, defensive applications. This paper highlights four clusters o