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Macrocyclic peptides are promising therapeutic modalities due to their ability to target protein-protein interactions (PPIs) with high specificity and affinity. In contrast to their linear analogues, macrocycles are conformationally constrained and the lack of N- and C-terminal make them more resistant to metabolic degradation. Advances in de novo peptide drug discovery, such as the Random non-sta

Diffuse large B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) are aggressive non-Hodgkin lymphomas often diagnosed at advanced stages in elderly patients. Current tools for patient stratification do not sufficiently identify patient groups resistant to treatment. The presence of CD11c+ cells has previously been associated with pro-inflammatory tumour-immune microenvironment (TIME), while CD

Denna studie syftade till att undersöka samband mellan prokrastinering, rutin, livstillfredsställelse, inre motivation och fysisk aktivitet hos studenter på Lunds Universitet. Vidare undersöktes om det går att predicera både prokrastinering och livstillfredsställelse med resterande faktorer, och sist utforskades det om det fanns någon skillnad i resultaten mellan de olika fakulteterna vid universiThis study aimed to investigate the relationships between procrastination, routine, quality of life, intrinsic motivation, and physical activity among students at Lund University. Furthermore, the study examined whether procrastination and quality of life could be predicted by the other factors, and finally explored if there were any differences in the results between the various faculties at the

Examensarbetets titel: När kris för en blir möjlighet för en annan Seminariedatum: 30 maj 2024 Ämne/kurs: FEKH69, Examensarbete i redovisning på kandidatnivå, 15 högskolepoäng Författare: Anna Gustafsson, Ebba Fröberg och Tilda Loudd Handledare: Mattias Haraldsson Fem nyckelord: Finansiell kommunikation, kriskommunikation, accountteori, legitimitet, krig Forskningsfråga: Hur väljer företag som påv

This paper draws on Anwar Shaikh’s formalization of the Classical theory of unemployment to analyze the historical development of the structural relationship between the wage share and unemployment in France from 1950 to 2020. The main findings include that the decline of central democratic economic planning coincides with the consolidation of a structural relationship between the two variables, a

In this thesis, a convolutional neural network was designed to perform real-time image classifications of ten product classes within a fast-paced, unstable manufacturing environment for quality control, while also linking it to a business case. Out of six eligible models that performed well on test data, only one proved good performance in simulated test runs, using out-of-sample test data. The fi

Sweden grapples with a critical issue: its extensive water infrastructure is nearing the end of its lifespan. While investment shortfalls increase this challenge, concerns linger about the potential mismanagement of existing assets. This research investigates how Swedish water utilities are strategically managing their ageing infrastructure. By exploring their utilisation strategies, the study aim

Over the last 30 years scientists have studied the morphological and mineralogical proofs of past aqueous activity on Mars. NASA’s latest flagship mission, the Mars 2020 mission with its Perseverance rover, landed in Jezero crater in 2021. Perseverance is tasked with investigating the wet history that has partially formed today’s Mars, and more specifically, find specific indicators for potential

Kandidatuppsatsen undersöker effekterna av buzzwords inom informatikforskning; den granskar hur dessa termer formar forskningsagendor, metoder och gemenskapsidentiteter genom Social Identity Theory. Studien använder en kvalitativ forskningsansats där data samlades in genom intervjuer från medvetet utvalda akademiker inom informatikområdet och analyserades tematiskt, vilket ledde till slutsatsen omThe bachelor’s thesis explores the impact of buzzwords in informatics research; examining how these terms shape research agendas, methodologies, and community identities through the lens of Social Identity Theory. The study employs a qualitative research approach where data were collected through interviews from purposefully selected academics of the informatics field, and were thematically analyz

Studien utforskar hur konsumenter i Generation Z upplever att digital marknadsföring på sociala medier påverkar deras konsumtion av skönhetsprodukter. Med syftet att öka kunskap samt förståelse för faktorer bakom Generation Z konsumtion av skönhetsprodukter använder sig studien av en kvalitativ metod. Med ett kriteriestyrt urvalsmetod samlades empiri in från 11 stycken respondenter som alla tillhö

In democracies, elections are events in which the public evaluates not only the promises for the coming years, but also the actions of the past period. When an incident adversely affects the welfare of all or part of a society, such as an economic crisis or a natural disaster, the general expectation according to the retrospective voting theory is that society will punish those responsible through

Människokroppen består av en otalig mängd celler, där varje enskild cell är omsluten av ett så kallat membran. Likt ett äpple där skalet omsluter och skyddar fruktköttet skyddar membranet cellen. En cell kan inte överleva utan ett membran. Förutom membranet är cellen också beroende av en fungerande transport av vatten och andra näringsämnen över membranet. För att kunna transportera ämnen över memIntroduction: The aim of this project is to study if the predicted model of the interaction between aquaporin-5 (AQP5) and CLIP2 is accurate by introducing single point mutations in the predicted interaction site of CLIP2 and see if it affects the interaction or not. Background: Aquaporins are essential membrane proteins for many biological processes. The regulation of aquaporins is crucial for c

This thesis analyses relationships between the litterfall components needles, twigs, flowers, fruits, and total litterfall and climate variables (wind speed, air temperature, relative humidity, and precipitation) in a coniferous forest located in southern Sweden. Needles, twigs, and total litterfall were positively correlated with daily average as well as maximum wind speed, whereas negatively cor

Pinus sylvestris (tall) är en betydelsefull trädart i Sverige och Europa, både ekonomiskt och kulturellt sett. Trädet infekteras dock av den destruktiva rottickan (Heterobasidion spp.) vilket resulterar i stora ekonomiska förluster inom skogsindustrin, med en uppskattad monetär förlust på ca 800 miljoner EUR årligen i Europa. Det är svårt att upptäcka svampen i tidiga infektionsstadier eftersom inPinus sylvestris (Scots pine) is an important tree species in Sweden and Europe, both economically and culturally. However, the highly destructive root rot fungi Heterobasidion spp. infect P. sylvestris and cause major economic losses in the forest industry, estimated to about 800 million EUR annually in Europe alone. Detection of the fungus in early stages is hard, as the infection mainly stays i

Inom partikelfysik, går de teoretiska och experimentella aspekterna hand i hand. För att förstå hur partiklar växelverkar med varandra och kunna förstå experimentella resultat, behövs en teoretisk modell av interaktionerna. Feynmandiagram erbjuder exakt detta, ett verktyg för att simpelt visualisera partikelprocesser. Med Feynmandiagram är det möjligt att förstå vilka processer som är möjliga och This thesis explores the simplifications the chirality-flow formalism brings the calculations of scattering amplitudes in massless QED. We explain Feynman diagrams and chirality- flow diagrams to emphasize how the calculations of scattering amplitudes differ. It is studied how applying the chirality-flow formalism simplifies the calculations. The work focuses on calculations with and without exter

Chirality can be understood as a property of an object that cannot be superimposed on its mirror image, such as our left and right hands. It is ubiquitous in nature and can also be found in the photosynthesis process involving chlorosomes from green sulfur bacteria. Understanding the dynamics of chiral properties in chlorosomes, due to the excitons formed by the interaction between bacteriochlorop

The construction industry has always been changing and adapting to new innovations, values, requirements, and goals from the outside world. These days are no different. The climate change is still mostly relevant and everything we could do to mitigate this should be applied in the construction sector. It is nowadays a known fact that buildings represent a significant portion of the carbon dioxide

Heart rate variability (HRV) is a measure of the variation in the time intervals between heartbeats. HRV can provide insights into the condition of the heart as well as the state and interaction of the sympathetic and parasympathetic nervous systems. HRV can be measured over shorter periods (5 minutes) or longer periods (up to 24 hours). Similar to pulse, HRV is linked to respiratory rate. During