Filtyp
We revisit the discussion on family limitation through stopping and spacing behavior both prior to and during the fertility transition. Using the birth histories of 13 519 settler women in nineteenth century South Africa we find no evidence of parity specific spacing prior to the transition. In addition we find no differences in spacing behavior based on differences in time invariant economic and
Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial wall. CD4+ T cells, some of which recognize peptide components of LDL as antigen, are recruited to the forming lesion, resulting in T-cell activation. Although these T cells are thought to be proatherogenic, LDL immunizat
Background: Chronic pain is a highly prevalent disease, leading to high health care costs, impaired productivity, and decreased quality of life. An artificial intelligence (AI)-powered, digital tool for self-management (PaindrainerTM) has been shown to be an effective treatment in chronic pain and may have potential to reduce the burden on costs and quality of life.Objective: The objective of thisBackgroundChronic pain is a highly prevalent disease, leading to high health care costs, impaired productivity, and decreased quality of life. An artificial intelligence (AI)-powered, digital tool for self-management (PaindrainerTM) has been shown to be an effective treatment in chronic pain and may have potential to reduce the burden on costs and quality of life.ObjectiveThe objective of this stu
While tau pathology is closely associated with neurodegeneration in Alzheimer's disease (AD), our prior work using multi-modality imaging revealed that mismatch between tau (T) and neurodegeneration (N) may reflect contributions from non-AD processes. The medial temporal lobe (MTL), an early site of AD pathology, is also a common target of co-pathologies such as limbic-predominant age-related TDP-
We describe the design and clinical utility of a digital tool aimed to increase the quality of life for chronic pain patients. PainDrainer™ is a drug-free, self-management tool, powered by artificial intelligence that adapts to the self-reported activities of each individual patient, resulting in a truly patient-centric support. The tool was tested in an open label, one-arm pilot study performed i
This chapter examines the integration of living materials into architectural design, focusing on the use of mycelium composites formed through fungal biotransformation. As architecture faces increasing demands for environmental responsibility, material innovation has turned toward biological systems capable of replacing high-impact construction materials. Mycelium, the filamentous body of fungi, o
Waste sorting is a cognitively demanding task with high environmental stakes. To support research on the categorisation and decision processes underlying waste sorting behaviour, this paper introduces an evaluated stimulus set of 790 images of naturally occurring waste items. The images were sampled from Danish and Swedish household waste, visually standardised, and evaluated by 526 Swedish partic
This study investigates the long-term social consequences of early-life exposure to adverseconditions in nineteenth-century Poznań. Using linked individual-level records from thePoznań Historical Population Database for birth cohorts 1830–1855, we examine howprenatal stress, infant mortality, early-childhood disease burden, and fluctuations in rye pricesinfluenced the likelihood of marriage and in
A key aspect of imperialism, colonialism, and capitalism is frontier-making. Frontiers are essential for ambitions of appropriation and extraction. This paper explores the discursive practices of frontier-making in Scandinavia including the conceptualization of parts of this region as empty space and ripe for exploitation, as wild, unruly and in need of domestication. These regions have historical
Breastfeeding confers a wide range of benefits to mothers and children, and in many contextsmay continue for several years after the birth of a child. As a result, breastfeeding duringpregnancy (BDP) is a common occurrence throughout low- and middle-income countries.Nevertheless, yet there has been little research into its association with the health of breastfedchildren or the outcomes of the pre
Studies showing that large-scale public health interventions in early life have lastingconsequences are still scarce and rarely disclose the mechanisms. In 1931–1946, the Swedishstate reformed the childbirth institutional system that led to the openings of the new maternitywards and to the gradual decline in home deliveries assisted by midwives. Maternity wardsoffered improved conditions for a mot
Abstract – Background: Cytological examination of a fine-needle aspirate (FNA) is a minimally invasive modality that is increasingly used in the diagnosis of lymphoma. Flow cytometry and other ancillary tests make an important contribution to the diagnostic value of FNAs of lymphoid lesions. This review follows the recent publication of the first edition of the WHO Reporting System for Lymph Node,
The high prevalence (>5%) of autoimmune hypothyroidism (AIHT) provides a unique opportunity to dissect genetic contributions to systemic and organ-specific autoimmunity. Here we performed a genome-wide association meta-analysis of 81,718 AIHT cases in FinnGen and the UK Biobank, identifying 418 independent signals (P < 5 × 10−8). At 48 of these loci, a protein-coding variant is, or is highly corre
Urban meteorology, the study of atmospheric phenomena in urban areas, is vital for understanding the dynamic interactions between rapid urbanization and environmental changes. Over the past two decades (2004–2024), urban heat islands (UHIs), extreme rainfall, pollution, and temperature anomalies have intensified, adversely affecting human health, infrastructure, and ecosystems worldwide. The prese
BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre
Methacrylated Pluronic triblock copolymers are widely used as photo-cross-linkable hydrogels, yet the effect of terminal methacrylation on self-assembly and thermoreversible gelation prior to cross-linking remains poorly understood. Here, we systematically investigate how the degree of methacrylation influences micellization, micelle packing, and gelation in Pluronic F127 using differential scanni
Technological advances in computed tomography (CT) have highlighted limitations of traditional dose descriptors such as computed tomography dose indexvol and dose-length product, particularly for wide-beam and modulated acquisitions. This study investigates a CT-specific, operational air kerma–area product derived from time-resolved measurements using small solid-state dosemeters mounted at the ga
