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ObjectivesPatient perceived benefit of treatment for cleft lip and/or palate is of great importance since it is central to development of cleft care. CLEFT-Q is a cleft-specific questionnaire on health-related quality of life. Test-retest reliability, aspects of responsiveness and interpretability are yet to be established for CLEFT-Q. This study aims to investigate these psychometric characterist

This study investigated the birth prevalence of cleft lip and/or palate (CL/P) in Sweden between 2000 and 2020 using data from the Swedish National Medical Birth Register, which includes over 97% of children born in the country, and its subregister the National Register of Congenital Anomalies. The dataset included 2,230,771 anonymized children, with the variables year of birth, sex and diagnoses

Astrocytes are essential for maintaining neuronal health and regulating the brain's inflammatory environment. In this study, we developed an adeno-associated viral vector (AAV9) designed to selectively overexpress glial cell line-derived neurotrophic factor (GDNF) in astrocytes, using the astrocyte-specific GFAP promoter and TdTomato for transduction tracking. This approach yielded targeted GDNF e

Bakgrund: Det är ett välkänt faktum att den demografiska utvecklingen kommer att kräva nya arbetssätt för att äldre ska kunna få vård i liknande omfattning som tidigare. Förhoppningen har ställts till införandet av välfärdsteknik som en viktig del av kompetensförsörjningen, inte bara för att den kan bidra till att upprätthålla välfärden trots fler äldre, utan också genom att göra äldreomsorgsarbet

Tackling biodiversity loss requires not only scaling up financial resources but also improving the governance of how such resources are mobilized, allocated, and accounted for. This paper reviews recent peer-reviewed literature (2019–2023) on biodiversity finance governance, focusing on three interrelated themes: financial instruments and mechanisms, governance structures, and critical and normati

Natural gas/diesel dual-fuel combustion is a novel technique that offers high thermal efficiency and reduced emissions without requiring extensive hardware changes or complex aftertreatment systems. Previous study conducted on the same setup has shown that increasing the diesel mass split ratio (SR) between two injections and advancing the start of first injection (SOI1) improved NOx, HC emissions

It has been shown by Fano [1] that photoionization of a cesium atom by a laser pulse tuned to the vicinity of a Cooper minimum generates spin-polarized electrons. Here we show that while photoionization of rare gases does not provide large spin polarization in the vicinity of the Cooper minimum, the Fano resonances yield much higher overall spin polarization (≥40%). The spin polarization increases

With calls for increased greenery in cities to safeguard biodiversity and its associated benefits to humans, urban vegetation must be managed carefully and efficiently. It is time to change paths from current spurious attempts to manufacture resilience and instead usher in evidence-based urban greening to secure ecosystems for the future.

Anthropogenic land-use change (LUC) substantially impacts climate dynamics, primarily through modifications in the surface biogeophysical (BGP) and biogeochemical (BGC) fluxes, which alter the exchange of energy, water, and carbon with the atmosphere. Despite the established significance of both the BGP and BGC effects, their relative contribution to climate change remains poorly quantified. In th

This paper investigates the relationship between debt, time and power by studying over-indebted young adults’ lived experiences of temporality. Empirically, the paper is based on recurrent interviews with 18 over-indebted young adults (aged 18–25) in Sweden and is analytically centred on three phases of indebtedness: entering the credit market, becoming over-indebted, and being over-indebted. The

The transition to the Nordic Bronze Age included new technological innovations, social institutions and sociopolitical structures pushed by extensive long-distance exchange of metals and other exotica. However, traditional views often oversimplify this as a simple two-way trade system, failing to adequately explain the complex interactions in and between the regions like Scandinavia in which the s

Main conclusion: Chloroplast protein transport depends on the SEC1 translocase. Barley xan-m mutants, deficient in SECA1, lack chlorophyll and die as seedlings. Their yellow phenotype indicates that carotenoid chemistry is less SEC1-dependent. Chloroplast proteins encoded by genes located in the cell nucleus need to be transported across up to three chloroplast membranes to find its correct locati