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INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the associa
The bone marrow (BM) niche is a complex cellular, molecular, and physical microenvironment capable of homing and supporting hematopoiesis. It is characterized by its ability both maintain and to drive hematopoietic stem and progenitor cells (HSPCs) self-renewal and differentiation which ultimately generate all blood cell types. However, how the niche elements interact in a human context remains la
Water damage affects both residents and buildings. Issues include moisture, climate impact and repair costs that amount to immense resources. Because of these, immense resources research is important to undertake to reduce and limit the extent and effects of water damage. This study aimed to compile and review the literature on water damage in buildings. Literature distribution, the status, conseq
The pending ecological crisis has ushered in a need to rethink how electricity is produced and consumed, which in turn will require new ways of maintaining system balance. One solution that has gained traction over the past decade is the idea of user flexibility. User flexibility is by some deemed integral to the transition towards a low-carbon society and to the decarbonization agenda, and its inThe pending ecological crisis has ushered in a need to rethink how electricity is produced andconsumed, which in turn will require new ways of maintaining system balance. One solution that hasgained traction over the past decade is the idea of user flexibility. User flexibility is by some deemedintegral to the transition towards a low-carbon society and to the decarbonization agenda, and itsintegr
Tropical ecosystems have an important role in global change scenarios, in part because they serve as a large terrestrial carbon pool. Carbon protection is mediated by soil aggregation processes, whereby biotic and abiotic factors influence the formation and stability of aggregates. Nutrient additions may affect soil structure indirectly by simultaneous shifts in biotic factors, mainly roots, and f
The influence of ectomycorrhizal fungi on the soil bacterial community was studied by growing pine seedlings in artificial soils consisting of a peat/sand mixture amended with microcline, biotite or apatite. In the microcline-amended and unamended soils both Suillus variegatus and Paxillus involutus reduced bacterial activity as measured by thymidine incorporation. S. variegatus grew best in the b
We live in ‘Tomorrowland’; a land at the nexus of social science and natural science where the solution to our problems will be found tomorrow. The paper addresses the impossibility of international relations by proposing an alternative approach located in critical social theory. The paper utilises critical social theory to critique contemporary liberal assumptions and rationalisations of cultures
Delayed cerebral ischemia (DCI) occurs in up to one third of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH). Untreated, it leads to secondary cerebral infarctions and is frequently associated with death or severe disability. After aneurysm rupture, erythrocytes in the subarachnoid space lyse and liberate free hemoglobin (Hb), a key driver for the development of DCI. Hemoglobin i
The European Union (EU) has been struggling with simultaneous crises of sovereign debt and fiscal austerity; refugees from conflicts in Afghanistan, Iraq, and Syria; and the rise of populist far-right parties across Europe. But behind these challenges lie less visible insecurities about economic prospects, social wellbeing, and a widespread expectation that the EU is unable to answer the challenge
Trots att socialpolitisk och omsorgsinriktad forskning i flera decennier visat på klara samband mellan undermåliga arbetsvillkor i svensk äldreomsorg och bristande kvalitet kvarstår problemen. Kan samarbete mellan forskning och konst bidra till att vi går från ord till handling och agerar för en bättre äldreomsorg? I ett forskningsprojekt om moralisk stress och moraliskt aktörskap i svensk äldreom
For the first time a measurement of 8B + 64Zn reaction has been performed at HIE-ISOLDE at CERN at energies around the Coulomb barrier, to understand how the debated halo structure of the light nucleus can affect reaction dynamics.
Exploring and rethinking the boundaries of the European Union’s action and inaction invites recognition that: (i) we are living in an era of rapidly accelerating 'planetary politics'; (ii) the 'normative power' approach provides a normative, explanatory, and practical theory of EU action within this era; (iii) the EU in planetary politics must interweave social, economic, environmental, conflictua
Most present-day research on mindfulness treats mindfulness as a variable that is studied in relation to other variables. Although this research may provide us with important knowledge at the population level and mechanism level, it contributes little to our understanding of the phenomenon of mindfulness as it is experienced and enacted at the person level. The present paper takes a person-oriente
Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic
BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on the microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS
CDchorus and string orchestraI. Darkness shall cover the earth / Jesaja 60:2-3 ; II. How dark, O Lord / Thomas Morell ; III. A thick darkness / 2 Mosebok 10:21 ; IV. Total eclipse! / Newburgh Hamilton (efter John Milton)14 min
For mixed chorus and solo celloTexts from the poetry collections in the Lund University Special Collections archive “Witnessing Genocide"
We live in ‘Tomorrowland’; a land at the nexus of social science and natural science where the solution to our problems will be found tomorrow. The paper addresses the impossibility of international relations by proposing an alternative approach located in critical social theory. The paper utilises critical social theory to critique contemporary liberal assumptions and rationalisations of cultures
