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Background: Antithrombotic treatment might affect bleeding symptoms, identification of bleeding source and treatment for patients with acute gastrointestinal bleeding. This study aims to investigate possible differences in initial bleeding symptoms, identified bleeding site and treatment of patients with or without antithrombotic medication admitted for gastrointestinal bleeding. Methods: All cons

Background: Polygenic risk scores (PRS) are not yet standard in clinical risk assessments for familial breast cancer in Sweden. This study evaluated the distribution and impact of an established PRS (PRS313) in women undergoing clinical sequencing for hereditary breast cancer. Findings: We integrated PRS313 into a hereditary breast cancer gene panel used in clinical practice and calculated scores

Background: Adequate sleep is crucial for children’s health, especially for children with ADHD and concurrent sleep problems. There is a need for more studies focusing on sleep problems in children with ADHD as these problems may exacerbate ADHD symptoms and vice versa, impacting negatively on everyday life. The aim of this study was to investigate the differences in health-related factors between

Sustainable wildlife management should, amongst others, safeguard human health. This study concerns rural residents’ perceived quality of life and the potential effect of large carnivores (LCs) on psychological health outcomes (life satisfaction, anxiety symptoms, and exhaustion). One group of rural residents that appears to be especially vulnerable when the number and range of LCs increase is she

Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may influence lung and immune system development, but previous epidemiological studies are inconclusive and have not extended into young adulthood. Objective: To examine associations between prenatal exposure to a mixture of PFAS and respiratory and immune-related outcomes in a cohort of males. Methods: We studied 866 male

Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediated RAP250 silencing in BAT reduces body weight and fat mass and enhances glucose oxidation, thereby indicatin

The Middle Darriwilian Isotopic Carbon Excursion (MDICE) is one of the globally recognized positive excursions in carbon isotope chemostratigraphy, but mainly documented by δ13Ccarb data in previous research. In this paper, new stable organic carbon isotope data (δ13Corg) are presented from the Hule-1 core from the southern Anhui Province of southern China. The core constitutes an Ordovician silic

Background: Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort. Methods: This cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50–64 years, n = 8,957). Sodium

Traditional methods for microbial water quality testing take up to two days to produce results, putting humans in contact with this water risk during this period. Flow cytometry, including with online capacity, is a fast and efficient way to profile microbes in water. In this study, Escherichia coli concentrations determined by Colilert18 and flow cytometry profiles from the same water samples wer

Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was

Purpose of Review: This review synthesizes current knowledge of the aggregation pheromones of Ips bark beetles specialized on coniferous hosts. The pest potential of these insects is increasing globally due to climate change and anthropogenic disturbances. The high aggressiveness of some species results from coordinated mass attacks on trees, mediated by male-produced aggregation pheromones. Bring

Background: The European Union (EU) AI Act (AIA) aims to facilitate trustworthy Artificial Intelligence (AI) systems, especially for safety-critical use cases. Compliance with this new regulation entails a multitude of legal, technical, and organizational challenges for the providers of affected systems.Objective: This regulatory compliance engineering research aims for an empirical exploration an

Telomerase plays an important role in sustaining eukaryotic linear chromosomes, as elongation of telomeres is needed to counterbalance the shortening occurring in each replication round. Nevertheless, in telomerase-deficient cells, Alternative Lengthening of Telomeres (ALT) pathways can maintain telomeres by employing recombination-based mechanisms. In the budding yeast Naumovozyma castellii, effe

A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [18F]-metafluorobenzylguanidine (mFBG), [68Ga]Ga-DOTA-TOC and [18F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [123I]-metaiodobenzylguanidine (mIBG). The methods

The aim of this thesis is to explore how methods from survival and event history analysis, namely relative risk regression, can be used to estimate prior probabilities in criminal cases, based on the distance between the potential perpetrator’s residence and the crime scene as well as further characteristics of the potential perpetrator. The locations of potential perpetrators residences can be mo

Bacteria: Building the Future from Thin Air Imagine what would happen if you could make nylon and other things that are needed to create everything from clothes to plastic containers with the use of microorganisms. It may seem far-fetched, but it’s getting closer to becoming reality. All you would need to get started is to help a few species of very special bacteria get even better at something t

PUS7 role in cellular adaptation to metabolic stress When we hear the word metabolism, our minds often jump to calories and diets. Cellular metabolism however refers to all essential mechanisms that keep our body up and running. Unsurprisingly, complex networks navigate this sensitive system, with many pathways that allow adaptation to changing and stressful environments. If this delicate balance

Black carbon (BC), a major component of fine particulate matter (PM2.5), has been implicated in adverse neurodevelopmental outcomes, including autism spectrum disorders (ASD). While PM2.5 has been associated with increased ASD risk, the specific role of BC remains uncertain. This study aimed to assess prenatal exposure to BC and risk for ASD development in a low exposure setting, using a large, hi

Temperature impacts on microbiological processes are crucial for soil biogeochemistry and ecosystem functioning, yet existing models either fail to capture microbial temperature dependences across the full biokinetic range or risk overparameterization. Here we present the “Dual-Kinetics Ratkowsky” model (Ratkowsky DK), which simultaneously describes temperature dependences of microbial growth and

Background: Monitoring of healthcare quality is typically focused on differences between group averages in relation to a desirable benchmark. However, we need to consider (i) the existence of interconnected socioeconomic axes of inequality like age, sex, income, and country of birth and (ii) individual heterogeneity around group averages. Additionally, (iii) we need clear criteria to quantify grou