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The MNS blood group system antigens (M, N, S, s, U, and other high- and low-frequency antigens) are carried on glycophorins A and B, or hybrid proteins thereof. Antibodies to these antigens can be clinically significant, especially anti-S, anti-s, and anti-U. The Duffy blood group system antigens (Fya, Fyb, Fy3) are carried on the atypical chemokine receptor 1 (ACKR1). Antibodies to the Duffy anti
A common and growing issue in scientific research and industry is that of storing and sharing ever-increasing datasets. In this paper we document the development and applications of Baler - a Machine Learning based tool for tailored compression of data across multiple disciplines.
The Cold War shaped the Danish landscape and cityscape profoundly. Numerous bunkers, military and civilian remain today as testimonies of a time where fear of a nuclear Third World War was imminent. This chapter delves into “the bunker” as materiality and myth, drawing inspiration from bunker studies from a broad range of fields including history, geography and architecture. Subsequently, this cha
Introduction: Understanding violent criminality and its impact on health and eventually the risk of premature mortality is important for efficient future interventions. This study aimed to explore the effect violent criminality had on premature mortality (i.e., death before the age of 65) among individuals with substance use disorders (SUDs). Methods: The cohort was created by identifying all Swed
Stable isotope analysis of plant remains recovered from archaeological sites is becoming more routine. There remains a lack of consensus, however, on how to appropriately select archaeological plant remains for isotopic analysis, how to account for differences in preservation and the effect of potential contamination, and how to interpret the measured isotope values in terms of the conditions in wStable isotope analysis of plant remains recovered from archaeological sites is becoming more routine. There remains a lack of consensus, however, on how to appropriately select archaeological plant remains for isotopic analysis, how to account for differences in preservation and the effect of potential contamination, and how to interpret the measured isotope values in terms of the conditions in w
A modern vehicle typically has up to ten different heat exchangers, ensuring prolonged technology life, improved performance, and passenger comfort. Heat exchangers for automotive applications are made of multilayer-clad brazed aluminium. They are mature products, having been used in passenger and commercial internal combustion engine vehicles for decades, and their use will continue in electrifie
Calcitonin gene-related peptide (CGRP) was suggested to play an important role in primary headaches as far back as 1985 and has been confirmed as playing a significant role in migraine pathophysiology. CGRP receptor antagonists are becoming more and more important for treatment of acute migraine attacks and for prophylaxis of episodic and chronic migraine. The development of drugs that bind CGRP o
Background: Digital work can be cognitively challenging especially for people with cognitive difficulties. New occupational therapy interventions are needed to empower these persons to self-manage challenges in digital work and everyday life. To address this need, the internet-based intervention 'Strategies for Empowering Activities in Everyday Life' (SEE 2.0) was tested.Aim: To explore and descri
Household salt, Sodium Chloride (NaCl), has been suggested as an appropriate material for retrospective and prospective optically stimulated luminescence (OSL) radiation dosimetry. The current paper investigates the potential application of NaCl pellets during a radiological and/or nuclear emergency, together with an existing portable reader, for application as a novel tool for in situ screening o
Background and objective:This study aims to enhance the performance of a closed-loop anesthetic depth control system by fusing noise-corrupted clinical measurements with a non-perfect pharmacological model.Methods:We implement a Kalman filter to constitute a trade-off between model prediction and measurement signal dependence for depth of hypnosis (DoH) control using a previously evaluated PID con
Nano-LEDs, with sizes smaller than 1 μm and close to sub-wavelengths, have received increasing attention because of their potential applications in next-generation self-emissive displays, visible light communication, optogenetics, maskless lithography, on-chip super-resolution microscopy, etc. In contrast to the top-down fabrication of nano-LEDs, where the efficiency drop caused by dry-etching rel
This study examines teachers’ use of evidence-based language learning techniques in the classroom and possible impact on student engagement. Video recordings of nine primary school teachers conducting interactive book reading with their students were analyzed both according to the Communication Supporting Classroom Observation Tool-Language Learning Interactions (CSCOT-LLI) and descriptively. QThis study examines teachers’ use of evidence-based language learning techniques in the classroom and possible impact on student engagement. Video recordings of nine primary school teachers conducting interactive book reading with their students were analyzed both according to the Communication Supporting Classroom Observation Tool-Language Learning Interactions (CSCOT-LLI) and descriptively. Q
OBJECTIVE: We investigated whether prepregnancy BMI (prePregBMI) in women with obesity was associated with differential DNA methylation (DNAm) in cord blood (CB) and whether DNAm may mediate the association of prePregBMI and early childhood BMI z score (BMIz).METHODS: From the Treatment of Obese Pregnant Women (TOP) study, 232 mother-child pairs were included. We conducted an epigenome-wide associ
AIMS, PATIENTS & METHODS: Dietary factors may regulate the epigenome. We aimed to explore whether a diet intervention, including excess sugar, affects the methylome in human sperm, and to describe the sperm methylome. We used Whole Genome Bisulfite Sequencing (WGBS) to analyze DNA methylation in sperm taken at three time points from 15 males during a diet intervention; i) at baseline, ii) afte
This theoretical paper adopts a procedural perspective to identify the challenges associated with the implementation of the full scope of approaches to circular public procurement (CPP). We contend that beyond considering CPP from a substantive standpoint (i.e. the procurement affects outside of the organization), adopting a procedural perspective (i.e. the procurement affects inside an organizati
Background and aim: The purpose of this study was to determine the effectiveness of antibacterial drugs through cluster analysis of antibiotic sensitivity data from clinical isolates of Acinetobacter and Pseudomonas spp., obtained from soft tissue wounds and burn injuries. Methods: The cohort included 76 clinical isolates of Acinetobacter and Pseudomonas spp. obtained from 141 patients (male – 95,
Atmospheric Carbon Dioxide (CO2), a significant greenhouse gas, drives climate change, influencing temperature, rainfall, and the hydrologic cycle. This alters precipitation patterns, intensifies storms, and changes drought frequency and timing of floods, impacting ecosystems, agri-culture, water resources, and societies globally. Understanding how global CO2 fluctuations impact regional atmospher
Context. While orbital analysis studies were so far mainly focused on the Galactic halo, it is possible now to do these studies in the heavily obscured region close to the Galactic Centre. Aims. We aim to do a detailed orbital analysis of stars located in the nuclear stellar disc (NSD) of the Milky Way allowing us to trace the dynamical history of this structure. Methods. We integrated orbits of t
Over the past two decades there has been increased interest in orphan drug development for rare diseases. However, hurdles to clinical trial design for these disorders remain. This phase 1a/1b study addressed several challenges, while evaluating the safety and tolerability of the novel oral molecule KL1333 in healthy volunteers and subjects with primary mitochondrial disease.KL1333 aims to normali
Promoting the bioeconomy to aid in the achievement of sustainability goals has increased demand for biomass as feedstock. Residual biomass from agricultural production is an attractive option, as it is a by-product that does not compete with food production. However, crop residues are important for the preservation of soil quality, especially for the maintenance of soil organic carbon. Therefore,
