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Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by
Complex recombinant biomaterials that merge the self-assembling properties of different (poly)peptides provide a powerful tool for the achievement of specific structures, such as hydrogel networks, by tuning the thermodynamics and kinetics of the system through a tailored molecular design. In this work, elastin-like (EL) and silk-like (SL) polypeptides are combined to obtain a silk-elastin-like re
One of the main challenges in regenerative medicine is the spatiotemporal control of angiogenesis, which is key for the successful repair of many tissues, and determines the proper integration of the implant through the generation of a functional vascular network. To this end, we have designed a three-dimensional (3D) model consisting of a coaxial binary elastin-like recombinamer (ELR) tubular con
Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In the current work, we aimed to assess the potential of the combination of MSCs with a proangiogenic elastin-like recombinamer (ELR)-based hydrogel in
Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and thei
Ti-6Al-4V alloy obtained by powder metallurgy (PM) is a good candidate biomaterial in the manufacture of dental implants but its inherent porosity makes it have worse corrosion behavior than conventionally obtained alloys. In order to improve the corrosion and biological properties, surface modification technologies could be used. The plasma electrolytic oxidation (PEO) process is a novelty proces
Even after fifty years since its introduction, the empirical Thornton’s structure zone diagram remains a valuable tool for predicting thin film microstructure. This diagram is essential for understanding the correlation between synthesis, composition, structure, and physical properties in emerging applications. In this work, we critically appraise this diagram by examining Sn─O thin films grown at
This article examines how the principle of ‘the best interests of the child’, as enshrined in the Convention on the Rights of the Child (CRC), is interpreted, constructed, and applied in court cases involving child custody disputes. These disputes provide a globally relevant example of the CRC’s social dynamics, as they often involve interactions and negotiations among diverse professional groups.
Technology has now globally gained a prominent place in national economic policymaking. Innovation is something to protect; access to technologies such as high-end chips is something to contest. For the West, discussion of national control over technology represents a departure from the globalization era’s understanding of trade, complementarity, and mutual prosperity.In Asia’s high-growth economi
Conventional Quality of Service(QoS) measurements are incapable to meet the demand for analysing communication performance on timeliness of information in Industrial Control Networks with many connected subsystems. The Age of Information (AoI) and the Age of Actuation (AoA) give a promise to be a solution. Many recent research articles cover theoretical aspects and analyse performance characterist
RegVis är en plattform som visualiserar nyckelvariabler inom regional utveckling och hur dessa förändras över tid och rum och hur de påverkar varandra. Genom kartor och grafer visualiseras sju variabler. Du kan välja att få en översiktlig bild av respektive variabel, eller fördjupa dig och jämföra variabler, geografiska områden etc med varandra.RegVis is a platform that visualizes key variables in regional development and how they change over time and space, as well as how they influence one another. Through maps and graphs, seven variables are displayed. You can choose to get an overview of each variable, or delve deeper and compare variables, geographic areas, etc. with one another.
Lignocellulosic biomass is an abundant, renewable and low-cost feedstock that plays a key role in the urgent transition from fossil-based resources to renewable and bio-based alternatives used within the chemical industry. Lignin, an aromatic heteropolymer, represents a significant fraction of lignocellulosic biomass, yet it is mainly considered a waste product. Over 50 million tons of Kraft ligni
Climatic feedbacks and ecosystem impacts related to dust in the Arctic include direct radiative forcing (absorption and scattering), indirect radiative forcing (via clouds and cryosphere), semi-direct effects of dust on meteorological parameters, effects on atmospheric chemistry, as well as impacts on terrestrial, marine, freshwater, and cryospheric ecosystems. This review discusses our recent und
The objective of this paper is to present a critical sustainability science research program, which is founded on two critical theoretical/philosophical traditions: critical realism and historical materialism. We elaborate these traditions to clarify what they can analytically offer to socioecological analyses in sustainability science and emphasize their prospective contributions to sustainabilit
Ice nucleating particles (INPs) play a crucial role in initiating ice crystal formation in clouds, influencing the dynamics and optical properties of clouds and their impacts on precipitation and the climate system. Despite their importance, there is limited knowledge about the vertical distribution of INPs. This study focuses on aircraft measurements conducted during spring 2018 above the boreal
The aggregation and accumulation of pathologic forms of the microtubule-associated tau protein into fibrils, eventually forming characteristic tangle pathology, hallmarks the majority of all dementia disorders which constitute the most prevalent family of neurodegenerative disorders. These so-called tauopathies are difficult to identify and diagnose, especially at early disease stages. The relativ
Objective: This study aims to provide a deeper understanding of what persons with lived experience and professionals with experience of patient safety, suicide research, and investigations consider to be most important in investigations of healthcare before suicide to learn and improve the care of suicidal patients. Method: This is a qualitative study based on 15 semistructured interviews with per
Enzymes are the quintessential green catalysts, but realizing their full potential for biotechnology typically requires improvement of their biomolecular properties. Catalysis enhancement, however, is often accompanied by impaired stability. Here, we show how the interplay between activity and stability in enzyme optimization can be efficiently addressed by coupling two recently proposed methodolo
The concept of high-risk plaque emerged from pathologic and epidemiologic studies 3 decades ago that demonstrated plaque rupture with thrombosis as the predominant mechanism of acute coronary syndrome and sudden cardiac death. Thin-cap fibroatheroma, a plaque with a large lipidic core covered by a thin fibrous cap, is the prototype of the rupture-prone plaque and has been traditionally defined as
