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Course development : lessons learned from usability evaluations

This article draws on usability evaluations of a behavioural change intervention delivered as a web-based course. Special attention was given to usability as the course is directed at older adults aged 70 and above. Experiences from the usability evaluations in a lab environment and the real world, followed by stepwise refinements, can serve as examples of what must be considered in developing cou

Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants

Background: Lumbar puncture (LP) is a common invasive procedure, most frequently performed to diagnose infection. Physicians perform LP in newborn infants with the help of an assistant using a strict aseptic technique; it is important to monitor the infant during all the steps of the procedure. Without adequate analgesia, LP can cause considerable pain and discomfort. As newborns have increased se

Bivalirudin Versus Heparin During PCI in NSTEMI : Individual Patient Data Meta-Analysis of Large Randomized Trials

BACKGROUND: The benefit:risk profile of bivalirudin versus heparin anticoagulation in patients with non-ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) is uncertain. Study-level meta-analyses lack granularity to provide conclusive answers. We sought to compare the outcomes of bivalirudin and heparin in patients with non-ST-segment-elevation myocardial

Protocol for the T-REX-trial : Tailored regional external beam radiotherapy in clinically node-negative breast cancer patients with 1-2 sentinel node macrometastases - An open, multicentre, randomised non-inferiority phase 3 trial

Introduction Modern systemic treatment has reduced incidence of regional recurrences and improved survival in breast cancer (BC). It is thus questionable whether regional radiotherapy (RT) is still beneficial in patients with sentinel lymph node (SLN) macrometastasis. Postoperative regional RT is associated with an increased risk of arm morbidity, pneumonitis, cardiac disease and secondary cancer.

Evaporation of serum after long-term biobank storage : A chemical analysis of maternal serum from a large Danish pregnancy screening registry

Background Relying on freezer stored biospecimens is preferred in epidemiolocal studies exploring environmental pregnancy exposures and later offspring health. Storage duration may increase the pre-analytical variability, potentially adding measurement uncertainty. We investigated evaporation of maternal serum after long-term biobank storage using ions (sodium, Na+; chloride, Cl-) recognized for s

Integrating Syrian refugee children in Turkey : The role of Turkish language skills (A case study in Gaziantep)

This study discusses issues around the integration of Syrian refugee children into the Turkish school system by using the case study of a secondary school in the city of Gaziantep in the southeast of Turkey. Based on focus groups with teachers at the school who engage with the growing number of Syrian refugee children in their classrooms, this study highlights in particular the role of Turkish lan

Factors affecting the success of CT-guided core biopsy of musculoskeletal lesions with a 13-G needle

Objective: To determine the value of CT-guided bone core biopsy and investigate factors that affect diagnostic yield and biopsy outcome. Materials and methods: The single-centre retrospective analysis included 447 patients who had CT-guided core biopsy with a 13-G needle (Bonopty®) from January 2016 to December 2021. Histological results or ≥ 6 months of clinical and radiological follow-up served

Finding Pictures in the Sky : Machinic Visions of Cloudscapes

Within cultural and art theory, there has been an emergence of attention placed on machine vision technologies as introducing a new regime of images and ways of seeing. This paper addresses this subject in the context of environment and nature through an inquiry into machinic ways of seeing cloudscapes. Attention is placed on how the cloud form presents a challenge to the logic of machine vision t