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Data on the impact of long term treatment with immunomodulatory drugs (IMiD) on health-related quality of life (HRQoL) is limited. The HOVON-87/NMSG18 study was a randomized, phase 3 study in newly diagnosed transplant ineligible patients with multiple myeloma, comparing melphalan-prednisolone in combination with thalidomide or lenalidomide, followed by maintenance therapy until progression (MPT-T
Theory predicts that we should find fast, ejected (runaway) stars of all masses around dense, young star-forming regions. N-body simulations show that the number and distribution of these ejected stars could be used to constrain the initial spatial and kinematic substructure of the regions. We search for runaway and slower walkaway stars within 100 pc of the Orion Nebula Cluster (ONC) using Gaia D
Background and purpose — Fast-track care programs have been broadly introduced at Swedish hospitals in elective total hip and knee replacement (THR/TKR). We studied the influence of fast-track programs on patient-reported outcomes (PROs) 1 year after surgery, by exploring outcome measures registered in the Swedish arthroplasty registers. Patients and methods — Data were obtained from the Swedish K
Background: Many individuals who will experience a first episode of psychosis (FEP) are not detected before occurrence, limiting the effect of preventive interventions. The combination of machine-learning methods and electronic health records (EHRs) could help address this gap. Methods: This case-control development and validation study is based on EHR data from IBM Explorys. The IBM Explorys Plat
Background: Symptom management in conjunction with proton beam therapy (PBT) from patient's perspective has not been explored. Such knowledge is essential to optimize the care in this relatively new treatment modality. Objective: The aim of this study was to explore the process of symptom management in patients with brain tumor receiving PBT. Methods: Participants were 22 patients with primary bra
This study focuses on the boundary-spanning nature of sustainable business model innovation, studying multi-stakeholder engagement and alignment. Drawing on the concept of boundary work, we explore the different types of organizational boundary changes between focal companies and their external stakeholders, investigating specifically the process of exploring, negotiating, disrupting and realignin
BACKGROUND: Research addressing perceptions of housing in people with Parkinson's disease (PD) is rare, and existing instruments capturing perceived aspects of housing are rarely used. Perceived housing comprises of several domains and is associated with health in general older populations. One such domain is meaning of home, captured by the Meaning of Home Questionnaire (MOH). The aim of this stu
Apolipoprotein M (apoM) participates in both high-density lipoprotein and cholesterol metabolism. Little is known about how apoM affects lipid composition of the liver and serum. In this study, we systemically investigated the effects of apoM on liver and plasma lipidomes and how apoM participates in lipid cycling, via apoM knockout in mice and the human SMMC-7721 cell line. We used integrated mas
In these proceedings, measurements of angular correlations between hadron pairs in pp collisions obtained by the ALICE experiment at the LHC are presented and compared with phenomenological predictions. Correlations between particles carrying the same and opposite quantum numbers are studied to understand the hadron production mechanism, and the difference between the same-sign and opposite-sign c
The ‘acid mantle’ of the human skin is considered crucial for several protective functions of the skin. It has been associated with numerous biological processes including enzymatic activities and barrier function for diffusional transport. The outer thin layer of the skin– the stratum corneum (SC) - is primarily responsible for the skin barrier function. In this paper, we investigate how the stru
Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods to 3,107 whole-genome-sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undescribed rearrangement signatures. We highlight interorgan variability of signatures and present a way
Objectives: We aimed to determine the lifetime genetic risk for anterior cruciate ligament (ACL) rupture. Methods: We used a twin study approach, linking the Swedish Twin Register with national healthcare data to form a 30 year, population wide, longitudinal twin cohort. We studied ACL rupture in this cohort of 88 414 identical and fraternal twin pairs, aged ≥17 years, to determine the familial ri
It is well recognized that human periodontal ligament cells (PDL cells) may represent local immune cells of the periodontal tissues. However, it is unclear whether they represent “true” immune cells, since they can produce pro-inflammatory cytokines not only after stimulation with bacterial lipopolysaccharides but also in response to other stimuli such as mechanical stress. Stimulation with bacter
This paper discusses approaches to facilitate, stimulate and support interaction both between academic teachers and in the classroom with a particular focus on digital tools and resources. A pragmatic approach is advocated, in which best practice experiences and the easiest ways to forwardthem are discussed and two suggestions presented.
We study belief formation in social networks using a laboratory experiment. Participants in our experiment observe an imperfect private signal on the state of the world and then simultaneously and repeatedly guess the state, observing the guesses of their network neighbors in each period. Across treatments we vary the network structure and the amount of information participants have about the netw
Two-dimensional laser-induced incandescence (LII) measurements were used for quantitative soot volume fraction ( fv) measurements in methane-air diffusion flames at pressures ranging from 0.1 to 0.5 MPa. Additionally, laser-induced fluorescence (LIF) was used for visualization of polycyclic aromatic hydrocar-bons (PAHs) considered as important soot precursors. A heat and mass transfer-based LII mo
Fitting a matrix of a given rank to data in a least squares sense can be done very effectively using 2nd order methods such as Levenberg-Marquardt by explicitly optimizing over a bilinear parameterization of the matrix. In contrast, when applying more general singular value penalties, such as weighted nuclear norm priors, direct optimization over the elements of the matrix is typically used. Due t
The seeking of potential rents directs flows of investment into built and natural environments, suffusing volatility into urban and rural landscapes, generating gentrification and other forms of land use change, and displacing lives and livelihoods to make space for ‘improvement’, ‘highest and best use’, ‘revitalization’, or the like. In this paper we argue that potential rents are captured at the
