Background: Metabolic reprogramming, particularly glycolysis, is essential in processes like cancer and immune response. While FGF21's role in hepatocyte glucose metabolism has been linked to glucose transporters and its impact on aerobic glycolysis and cellular growth in HCC remain unclear. In this study, we investigated FGF21-mediated modulation of glucose metabolism in HCC through mTOR and HIF1

Introduction: Sentinel vessels provide an important early indication of underlying ocular neoplasm. To date, there is no noninvasive technique available for imaging and mapping of their vascular supply, which remains largely unstudied. We aimed to map sentinel vessels in uveal melanomas noninvasively by laser speckle contrast imaging (LSCI). Case Presentations: This report describes a case series

In an often quoted sentence of his 1976 book "The Architecture of Form", Lionel March drew a clear distinction between science, interested in extant forms, and design, which initiates novel forms. The theories, methods, measures and diagrams of space syntax have often developed following this first more scientific scheme, and they have been concerned with the analysis of existing or projected buil

Convex maps were first introduced by Hillier and Hanson in "The social logic of space", and have since become a standard diagram of space syntax, particularly in the analysis of interior of buildings. Despite of their extensive use, the computer generation of convex maps turns out to be quite difficult. An algorithmic description of the process would afford an objective form of reproducing analysi

The higher education system has since the 2000s changed fundamentally in Finland, Norway, and Sweden. One reason behind this is so-called managerialism as a part of NPM, which means a shift towards more managerial forms of leadership, business-oriented aspects, and neoliberal university policies. Managerialism in all the Nordic countries conflicts with decades of collegial institutional tradition.

Wetland technologies applied on a farm level can be a useful solution for sustainable water management in the agricultural setting since they can influence water quantity and quality. WATERAGRI has tested different types of wetlands in three European countries - Italy, Austria and Sweden, covering different climate and geographical zones. The tests involved full-scale, pilot scale and prototype sy

This deliverable reports on Risk Assessment for Wetland Sediment Applications on Agricultural Land. The main content is a thorough and critical evaluation (literature review) of the wetland coupled agriculture and the related concerns such as nutrients, sediments and contamination risks. This will also be supported by the two case studies. Constructed wetlands act as traps for substances carried w

This chapter acts as an introduction to the book by introducing fundamental concepts relevant to the debate. It aims to provide a structure to think about the topic. A structure that has also influenced the structure of the book. Moreover, it provides a background to the debate and summarise the most important findings of the different chapters.

OBJECTIVE: We report the preliminary baseline characteristics in the ongoing phase 3 evoke and evoke+ trials investigating the safety and efficacy of oral semaglutide for early AD.BACKGROUND: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), is approved for use in type 2 diabetes (T2D) or obesity.DESIGN/METHODS: evoke (NCT04777396) and evoke+ (NCT04777409) are multicenter, randomi

Transmissibility has increased during the evolution of SARS-CoV-2, possibly by improved airborne transmission. An increased transmission was noted also in many hospitals. We analyzed SARS-CoV-2 in room air of hospitalized Omicron infected patients and compared results with previous findings with pre-Delta variants to study if SARS-CoV-2 was more prevalent in patient rooms after the introduction of

Rättspsykiatrisk vård befinner sig mitt i ett spänningsfält med tre poler: straff, vård och samhällsskydd. Den som är föremål för rättspsykiatrisk vård är en lagöverträdare dömd för brott till en påföljd, en patient som är omhändertagen för psykiatrisk tvångsvård och en person som är frihets-berövad med hänvisning till att personen utgör en samhällsfara. Detta medför att det frihetsberövande och ö

Generative AI tools (GenAI) are increasingly used for academic tasks, including qualitative data analysis for the Scholarship of Teaching and Learning (SoTL). In our practice as academic developers, we are frequently asked for advice on whether this use for GenAI is reliable, valid, and ethical. Since this is a new field, we have not been able to answer this confidently based on published literatu

As a dominant representative of biobased construction materials, an increased use of timber bears potential to contribute to climate change mitigation. This work investigated public attitudes towards timber as a building material, particularly focussing on the perception of fire safety properties and associated risks. In past studies timber’s susceptibility to fire was often acknowledged by stakeh

Genome-wide analyses of various taxa have repeatedly shown that immune genes are important targets of positive selection. However, little is known about what factors determine which immune genes are under positive selection. To address this question, we here focus on the mammalian immune system and investigate the importance of gene function and other factors such as gene expression, protein-prote

Acinetobacter baumannii (A. baumannii) is an opportunistic, Gram-negative human pathogen, which is predominantly found in hospital patients. Its antimicrobial resistance is escalating, leading to less efficient treatments, and an increasing interest in identifying new therapeutic drugs. Metals as antimicrobials are vital in healthcare and agriculture, and copper-containing surfaces are known to re

Agriculture is pivotal in the global economy but is challenged by unsustainable practices that harm the environment and aggravate social inequalities, particularly in sub-Saharan Africa (SSA). Women, making up half the agricultural workforce, often do not benefit equitably from their labour due to systemic gender inequalities. Applying a Feminist Political Ecology (FPE) lens reveals the unequal ge

The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor microenvironment, in which regulatory T cells (Treg) play a pivotal role in immunologic tolerance. In this study, we investigated the impact of complement facto

To reach the non-mobile majority, universities in many contexts, especially in the Global North, are investing in the internationalization of the curriculum at home (IoCaH); however, experience shows that top-down strategies are implemented differently across disciplines. It has been suggested that the role of academic disciplines, an under-investigated dimension, can explain this variation. Throu

This study employs asymmetric flow field-flow fractionation online coupled with small angle X-ray scattering at a synchrotron beamline, along with multiple downstream detectors, including multi-angle light scattering, dual wavelength UV and dRI. This setup enables size-resolved characterization of lipid nanoparticles, allowing for a detailed comparison between empty and cargo-loaded lipid nanopart