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Sustainable access to effective antibiotics is a main rationale for addressing antimicrobial resistance, for calls to enhance antibiotic supply security and for development support to promote health system capacity in low- and middle-income settings. Standard models for valuing pharmaceuticals fail to capture the full value of sustainable access to effective antibiotics. In effect, assessments of

Antibiotic persistence arises when a subset of cells in an otherwise susceptible bacterial population temporarily exhibits elevated tolerance to bactericidal antibiotics. While significant progress has been made in elucidating persister mechanisms, much of this research has focused on Gram-negative bacteria, and these findings are not always applicable to Gram-positive species. This study explores

BACKGROUND/AIM: Appendiceal adenocarcinomas are rare tumours with aggressive traits, most often diagnosed incidentally after routine appendectomy. Survival rates vary greatly between the different subgroups, and adenocarcinoma has the worst prognosis. Surgery is the only curative treatment, however, the long-term benefit of extended surgical resections over appendectomy has not been established. T

The characterisation of wood’s fracture behaviour is a challenging task due to its inherently complex microstructure and natural variability. Consequently, to accurately model wood for engineering applications, deterministic input parameters are rarely sufficient in, for example, finite element models; the stochastic nature of the material must be considered. In the present work, we aim to quantif

INTRODUCTION: Postural orthostatic tachycardia syndrome (POTS) is a complex disorder with challenging diagnosis and management.METHODS: This cross-sectional, multi-national, web-based physician chart audit described clinical features and management of POTS, offering insights into disease burden and outcomes before and after the COVID-19 pandemic.RESULTS: Physicians (n = 153), primarily cardiologis

The rate of change in adaptive laboratory evolution (ALE), in which a population of microorganisms is continuously cultivated under a specific selective pressure, is controlled by the cellular mutagenesis rate and the randomness of where in the genetic material mutations are introduced. The constant selection pressure makes it a crucial, yet slow, method in developing microorganisms with novel phe

BackgroundPatients with advanced ovarian cancer (AOC) who undergo primary and interval debulking surgery are often anemic at diagnosis, with iron deficiency being the most common cause. The aim was to investigate whether preoperative anemia and iron deficiency impact short-term recovery.MethodsThis retrospective cohort study included 262 patients with AOC who underwent surgery at Skane University

Background: Teaching quality is commonly assessed through classroom observation. However, observer ratings of teaching quality frequently exhibit limited psychometric quality. Beyond evaluating the ratings themselves, exploring the observation process and the design of the video environment may offer valuable insights into conditions that enhance rating accuracy. Aims: This study explored the clas

Virtual reality (VR) offers promising opportunities for procedural learning, particularly in preserving intangible cultural heritage. Advances in generative artificial intelligence (Gen-AI) further enrich these experiences by enabling adaptive learning pathways. However, evaluating such adaptive systems using traditional temporal metrics remains challenging due to the inherent variability in Gen-A

This paper examines the birth of the exploitative sockenlappssystemet (the ‘Parish Lapp’ system) in central Sweden during the early eighteenth century. Based on a foundation of control and eviction instituted in earlier laws, the 1720s saw a forceful rise in royal concern over the existence of nomadic Sámi in central Sweden. His Majesty King Fredrik I specifically expressed fear of damage to the r

This paper examines traces of Sámi habitation in southern and central Scandi-navia, particularly Sweden, addressing the late medieval period to the end of thenineteenth century. It begins with Swedish judicial policy against Sámi nomadismin central Sweden, followed by a discussion of medieval Sámi material culture insouthern Scandinavia. Further analysis addresses so-called Parish-Lapp indenture,w

The dissertation Deductionis coloniarum rationes & causae, submitted at Uppsala University in 1668 under the presidency of Johannes Schefferus, appears to be the firstcontribution to the Swedish discourse on the subject of colonisation and colonialism. In this paper, a translation of the text is presented with a commentary and a list of sources. In an introduction to the translation, which dis

In 1959, the politics of assimilation led to the creation of a set of municipally organised camps for Roma people in the Stockholm area. The camps were to function as controlled settlements of transition for Roma families awaiting proper homes. This paper focuses on one such camp – the Skarpnäck Camp – which existed longer than anticipated, to the point that its continued operation was criticised

During a period of 40 years in the second half of the 17th century, a process of industrialization was initialized in the northern part of the Torne River valley, northern Sweden. The industrialization was the result of global demand for copper and brass, but its practice was a local and regional encounter between different groups of people with a manifold of identities, languages, e

This chapter builds upon three streams of experience by its author: (a) one related to his six-year term as the first UN Special Rapporteur on human rights and counterterrorism (2005-2011), namely the identification of the absence of a proper international definition of terrorism as an important source of human rights abuses, (b) his observation of actual court practice and media coverage where de

Much scholarship has critiqued the fact that non-governmental organisations (NGOs), as a result of global neoliberalism and consequential state retreat, have become private service providers of children’s protection rights. But how can we explain the situation when neoliberal states also undergo autocratisation and take back service provision from NGOs, while at the same time preserving the privat

BACKGROUND: Intellectual disability (ID) and schizophrenia are known to separately carry a high risk of comorbidity of mental health and physical conditions. However, the prevalence and risk of comorbidities among people diagnosed with concurrent ID and schizophrenia have to date not been studied.METHODS: From a cohort including all people in Skåne, Sweden, the following three groups were establis