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Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clinical challenges by integrating advanced proteogenomic profiling, clinical metadata, with AI-driven digital pathology and machine learning analytics, a
Objectives To investigate the association of diabetes, hypertension and overweight/obesity with physical activity (PA), self-efficacy for pain and self-efficacy for other symptoms before and after a 6- week exercise and education intervention for knee and hip osteoarthritis (OA), and to assess outcome disparities based on metabolic health. Methods Register-based cohort study using the Swedish Oste
Objective Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are globally prevalent chronic diseases that affect millions of individuals in ageing populations. Hip and knee replacements are well established and effective treatments in patients suffering from end-stage OA. Understanding how T2DM influences the outcomes of these surgeries is important for optimising patient care and improving s
For the first time, reductions in cerebral β-amyloid pathology load and rate of cognitive and functional decline have been achieved in Alzheimer's disease, through pharmacological intervention in randomised controlled trials. However, the results from phase 3 randomised controlled trials of anti-β amyloid monoclonal antibodies are interpreted in different ways, with some experts supporting a clini
Subungual epidermoid inclusions (SEI) are small epithelial inclusions, sometimes solid but mostly with central keratinization of the onycholemmal type without a granular layer. Exceptionally, they become large enough to produce symptoms such as pain or swelling of the nail bed, resulting in subungual keratosis, onycholysis, or a dystrophic nail plate. Herein, we report a further case of SEI in a f
Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading source of health and social care expenditure for society. Before the advent of biomarkers, post-mortem examination was the only method available to establish a definitive diagnosis.
Reflection seismic data were acquired in the Sudret area of Gotland between 6 and 13 November 2023. Objectives of the survey were to obtain images of the subsurface down to the Precambrian basement in the vicinity of two cored boreholes that had been drilled earlier down to about 800 m. The seismic profiles were positioned to provide a better understanding of the sedimentary strata and local struc
The Kant Walks, 2003–2004 - Photographic seriesJoachim Koester’s series The Kant Walks explores the physical paths once walked by philosopher Immanuel Kant in 18th-century Königsberg (now Kaliningrad) Bydocumenting these routes, Koester uncovers physical layers of history, abandoned settlements, and forgotten places His photographs – often depicting empty,decaying urban landscapes – pose the quest
This chapter explores the production of Kalak (2023), emphasising the significance of locations, historical contexts and emotional economies in filmmaking in a Danish-Greenlandic context. This production navigates narrative and practical challenges through three layers of legitimisation. First, centring the narrative on a Danish character allows both Danish and Greenlandic filmmakers to engage wit
The molecular chaperone αB-crystallin is a small heat shock protein that inhibits the aggregation of, among others, Aβ42 and α-synuclein. These proteins are major hallmarks of Alzheimer's and Parkinson's disease, respectively. In order to understand the mechanism with which αB-crystallin performs its chaperone function it is essential to characterize its self-assembly in terms of aggregate size di
This chapter explores the emerging cinemas of Greenland and the Faroe Islands, two ultrasmall national film industries navigating the complexities of cultural identity, transnational collaboration, and economic constraints. While Greenlandic cinema has evolved through two distinct waves, first marked by national television productions and later by internationally recognized feature films, the Faro
Environmental stress can alter not only trait means but also trait variances - an often-overlooked evolvable feature with ecological and evolutionary relevance. We examine how dietary stress affects both the mean and variance of morphological and reproductive traits across two generations in clonal Daphnia. We manipulated maternal and offspring environments with high- (algae) or low-quality (cyano
This introduction to the In Focus section ‘Runaway Scandinavia’ provides background on the phenomenon of runaway and mobile screen production and presents the four short articles that follow. As the first joint effort to address this topic, the In Focus outlines, from a range of perspectives, how the region has become increasingly shaped by global production mobility, incentive-driven competition
Individuals can gain substantial benefits from collective actions.1,2,3,4,5,6,7 However, collective behaviors introduce new challenges, like coordinating actions, maintaining cohesion, and meeting the needs of different individuals. When making collective movements, leaders are typically thought to gain disproportionate benefits through the choice of more beneficial resources3 and/or earlier acces
More than 3500 samples of lichen genus Xanthoria s.l. were collected at 135 localities in the Baltic Sea–Kattegat area during 2022–2025. Of these, 177 were selected for phylogenetic analyses using ITS and mt-sequences. The phylogenetic tree of Xanthoria s.str. reveals 24 clades possibly corresponding to species, six of which are described, i. e. X. calcicola, X. coomae, X. ectaneoides, X. pedersen
The biogeographical origin of Betonica officinalis L. in Sweden has long been debated as to whether its populations represent natural postglacial relicts or human introductions. Using RADseq data from 42 individuals across 35 sites in 14 European countries, we analysed 9,598 SNPs to map genetic structure and infer relationships among regions. We found strong differentiation between western and cen
