Proactive identification of chemicals with skin sensitizing properties is a key toxicological endpoint within chemical safety assessment, as required by legislation for registration of chemicals. In order to meet demands of increased animal welfare and facilitate increased testing efficiency also in nonregulatory settings, considerable efforts have been made to develop nonanimal approaches to repl

Life in modern society is intricately intertwined with the results of continuous technological advances. Thishas given rise to daily routines where people are frequently exposed to a wide variety of chemicals.Though many of the chemicals do not generally induce adverse health effects upon normal exposure,several of them has the potential to negatively impact health. Indeed, in order to create prod

Glacier retreat caused by global warming alters the hydrological regime and poses far-reaching challenges to water resources and nature conservation of the headwater of Yangtze River, and its vast downstream regions with dense population. However, there is still lack of a robust modeling framework of the “climate-glacier-streamflow” in this water tower region, to project the future changes of glac

To protect public health, heat-related policies are increasingly being adopted by city authorities to address the unequal impact of heatwaves. Ahmedabad’s Heat Action Plan (HAP) is an acclaimed and successful policy response in India and beyond. While the pilot evaluation of the initiative suggests that almost a thousand deaths were avoided annually after its implementation, it is not yet clear wh

8 poems by Scottish poet Kathleen Jamie (b. 1962) in translation from English of Lars Gustaf Andersson, with a brief commentary.

The growth of building energy simulation tools has provided users with a variety of alternatives to model and simulate buildings. The algorithms used in each building energy simulation software are different and range from simple to highly complex. TEKNOsim is a simple design tool based on analytical and empirical algorithms. It is used for calculating building thermal loads and simulating indoor

The evolution of the traditional nuclear magic numbers away from the valley of stability is an active field of research. Experimental efforts focus on providing key spectroscopic information that will shed light into the structure of exotic nuclei and understanding the driving mechanism behind the shell evolution. In this work, we investigate the Z=6 spin-orbit shell gap towards the neutron dripli

Osteoarthritis of the carpometacarpal joint at the base of the thumb (CMC1 OA) is common and causes difficulty in grasp, grip, and fine manipulation of the hand. Surgery is recommended after failure of non-operative treatment, andevidence from short and medium-term follow-up studies shows successful relief of pain and return of function. Previous investigations of epidemiology and risk factors wer

Although some characteristics of incorporating verbs and non-incorporating verbs have been proposed in previous studies, little systematic cross-linguistic research has been done on restrictions on the types of verbs that incorporate nouns. Knowledge about possible verb-based restrictions on noun incorporation may, however, provide important insights for theoretical approaches to noun incorporatio

Städer var nykomlingar i det medeltida Skandinavien. Efterhand blev dock stadslivet något att eftersträva, en rikare tillvaro med en mångsidig miljö. Städer växte fram ur existerande behov och utifrån nya maktrelationer. Under lång tid hade människor inte behövt staden och det sammanträngda liv som den erbjöd. Landskapet bestod i stället av enstaka gårdar, hushåll med gemensam bebyggelse, jordagod

Our submission to the UNSR on the Right to Development (RTD) focuses on the significant changes that are taking place within the international architecture for Financing for Development (FFD) and their impact on the realization of the RTD. A key plank of the new FFD framework is the engagement of the private sector in the mobilisation and delivery of development finance, including the use of publi

Braided convolutional codes (BCCs) are a class of spatially coupled turbo-like codes that can be described by a (2), (3)-regular compact graph. In this paper, we introduce a family of (d v , d c )-regular GLDPC codes with convolutional code constraints (CC-GLDPC codes), which form an extension of classical BCCs to arbitrary regular graphs. In order to characterize the performance in the waterfall

Genomic instability is a characteristic of a majority of human malignancies. Chromosomal instability is a common form of genomic instability that can be caused by defects in mitotic checkpoint genes. Chromosomal aberrations in peripheral blood are also indicative of genotoxic exposure and potential cancer risk. We evaluated associations between inherited genetic variants in 33 mitotic checkpoint g