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Understanding the factors and mechanisms involved in beta-cell development will guide therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) is the key transcription factor that marks endocrine progenitors and drives beta-cell differentiation. Here we screen for binding partners of NGN3 and identify the deubiquitylating enzyme USP7 as a key regulator of NGN3

The failure of many countries in the Global South to catch up economically to the advanced economies of the Global North has long been a topic of interest to economic historians and development economists. Traditionally, researchers focused their attention on the question of growth –how can a country achieve growth to catch up? In recent years, however, a new research programme has begun to shift

Perceived fairness is a central determinant of acceptance or resistance toclimate policies. Resistance to climate policies is shaped by structural factors,including socio-economic conditions and cultural identities. But policy designaspects that are sensitive to perceptions of fairness can increase the public’sacceptance of the measures proposed. Overcoming resistance requires anunderstanding of t

Energy communities (ECs) are considered important in transitioning the energy system. They are of particular interest due to their potential to empower citizens and support a more just energy transition. However, experiences from ECs remain limited and vary across countries, thus raising questions on potential future advancements. In this article, we explore experiences from ECs in several Europea

Le philosophe Jean-François Lyotard fut invité en 1983 par le Centre de création industrielle (CCI) à rejoindre le projet d’une manifestation qui s’ouvrirait finalement deux ans plus tard. Intitulée « Les Immatériaux », elle allait constituer un jalon majeur dans l’histoire des expositions au xxe siècle. Appelé en tant que commissaire principal, Lyotard fit néanmoins le choix de s’acquitter de sa

En kort introduktion med övningar och lektionsplan med lärarhandledning för gymnasieskolan.Målet med detta material... är att för lärare erbjuda att så gott som färdigt lektionsupplägg för lärare i gymnasieskolan för att ta upp och behandla ämnet hatretorik på ett konstruktivt sätt. Ett bakgrundsavsnitt (INTRODUKTION, s. 4–21) ger en översikt och bakgrund till ämnet så att läraren kan känna sig tr

Covid-19 has triggered a massive global challenge with 1,576,069 overall confirmed cases, 1,545,429 recovered cases, and 30,640 deaths across Pakistan. Epidemiological models have always played an important role in understanding the dynamics of such infectious diseases. The severity of Covid-19 infection depends on several factors such as immune system and virus variants. Although detailed epidemi

Med utgångspunkt i unikt arkivmaterial undersöker denna avhandling skillnader i hur västliga demokratier styrt radio och television. Genom en jämförande studie av fyra länder följer den de intressekonflikter som präglat etermediepolitiken — från de tidigaste radioregleringarna till kabel- och satellit-tv:s genomslag under slutet av nittonhundratalet.Snarare än att tolka politiska konflikter kring Using original archival evidence, this doctoral dissertation describes and explains differences in how Western democracies have governed radio and television, tracing interest group struggles over broadcasting in four countries from early radio policy to the rise of cable and satellite television in the late twentieth century.Rather than framing political conflicts over radio and television as a b

Recension av Fred Radenbachs bok Nasjonalidretter

Private labels (PL) have gone from being a marginal and rather odd phenomenon in the gro-cery sector 20 years ago, to having a prominent role in the grocery retailing landscape, ac-counting for approximately 25-30% of what is sold in Swedish food stores today. Given the enormous turnover of the grocery trade, amounting to 326 billion SEK in 2023 according to Statistics Sweden (SCB), this is a rema

BACKGROUND: The MeToo-movement challenges the 'culture of silence' regarding sexual harassment (SH). There are few studies regarding this phenomenon in academic settings. The aim of this study was to investigate the relationship between having reported or disclosed SH, on the one hand, and background factors and general health and wellbeing of exposed individuals, types of SH and perpetrator chara

Abstract NRWC 2024 Internal marketing in changing times - Supporting personnel meeting customers in physical retail storesUlf Johansson, Lund School of Economics and management, Center for retail studies at Lund universityKristina Bäckström, Campus Helsingborg, Lund university, Center for retail studies at Lund universityA lot has been written about the change of retail in later years (Berman, 201

Den här rapporten syftar till att undersöka och analysera frågor kring handelns egna märkesvaror (EMV) och deras påverkan på konkurrens, priser, produktutveckling och maktbalans i dagligvarukedjan. Genom att betrakta EMV från ett konkurrensperspektiv, undersöker rapporten motiv och strategier bakom användningen av EMV, samt dess effekter på marginaler, prissättning och sortimentsbredd.Rapporten ko

Exceptional are the instances where explicit solutions to optimal control problems are obtainable. Of particular interest are the explicit solutions derived for minimax problems, as they provide a framework for addressing challenges involving adversarial conditions and uncertainties. This thesis presents explicit solutions to a novel class of minimax optimal control problems for positive linear sy

We present an explicit solution to the discrete-time Bellman equation for minimax optimal control of positive systems under unconstrained disturbances. The primary contribution of our result relies on deducing a bound for the disturbance penalty, which characterizes the existence of a finite solution to the problem class. Moreover, this constraint on the disturbance penalty reveals that, in scenar