Systemic lupus erythematosus (SLE) is an autoimmune disease involving many organ systems. The cause is not known, but a complex combination of environmental and genetic factors seems to be involved. In SLE upregulation of type I interferons, a hyperactive B-cell response, presence of autoantibodies against modified nuclear components, increased complement consumption, increased apoptosis and decre

Stable isotope analyses of tissues have been used to help delineate natal regions and routes of migratory animals. The foundations of such studies are isotopic gradients or differences representing geographic regions and habitat used by the organism that are retained in selected tissues. We sampled peacock butterflies Inachis io on a regional level in southern Sweden to study natural variation and

This article presents a research agenda about waste management from the perspective of management and organization studies. The agenda suggests that scholars should draw upon research on waste governance, lean management, the circular economy, and sustainable consumption. It also suggests, in a crossdisciplinary spirit, that scholars should heed research on waste within other social sciences and t

The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z, 8Z, 11Z, 14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 in the central nervous system (CNS) has provided a potential strategy for developing novel analgesics. Here we validated this strategy by examining

BACKGROUND: Sexual conflict theory predicts sexually antagonistic coevolution of reproductive traits driven by conflicting evolutionary interests of two reproducing individuals. Most studies of the evolutionary consequences of sexual conflicts have, however, to date collectively investigated only a few species. In this study we used the annual herb Collinsia heterophylla to experimentally test the

In order to deliver innovative and cost-effective IP multimedia applications over mobile devices, there is a need to develop a unified service platform for the future mobile Internet referred as the Next Generation (NG) all-IP network. It is convincingly demonstrated by numerous recent studies that modern multimedia network traffic exhibits long-range dependence (LRD) and self-similarity. These ch

Experiments with the new recoil separator, Transactinide Separator and Chemistry Apparatus (TASCA), at the GSI were performed by using beams of Ca-48 to irradiate targets of Pb206-208, which led to the production of No252-254 isotopes. These studies allowed for evaluation of the performance of TASCA when coupled to a new detector and electronics system. By following these studies, the isotopes of

According to our study, based on interviews with households in a residential area in Sweden, uncertainty is a cultural barrier to improved recycling. Four causes of uncertainty are identified. Firstly, professional categories not matching cultural categories—people easily discriminate between certain categories (e.g., materials such as plastic and paper) but not between others (e.g., packaging and

Abstract in Spanish A pesar de que el mercado laboral sueco ha permanecido relativamente intacto durante la crisis económica en los últimos seis años, la integración de personas con capacidad laboral reducida a causa de discapacidades es significativamente menor que la de otros grupos sociales. La legislación sueca sobre discapacidad y trabajo cubre varios aspectos en medidas de integración, antidEven though the Swedish labour market has been more or less intact during the financial crisis in the past six years, persons with reduced working capacity due to disabilities are significantly less integrated in the labour market than other groups in society. Swedish legislation on disability and work provides for a number of different aspects of integrative measures, anti-discrimination and prov

Immunoglobulin constant heavy G chain (IGHG) gene polymorphisms are associated with atopy and can be determined by the serum Gm allotypes. We studied whether certain polymorphisms are related to asthma severity and to the extent or intensity of allergic sensitization in asthmatic subjects followed from childhood to young middle age. Fifty-five subjects (28 males) with childhood asthma were all fo

The issue of strengthening local research capacity in Africa is again high on the health and development agenda. The latest initiative comes from the Wellcome Trust. But when it comes to capacity development, one of the chief obstacles that health sectors in the region must confront is the migration of health professionals to countries that offer more lucrative opportunities, like those in western

The model for permanent deformation in asphalt concrete (AC) layers used in the Mechanistic-Empirical Pavement Design Guide (MEPDG) was evaluated. Two instrumented flexible pavements were subjected to heavy vehicle simulator testing at three constant temperatures. Permanent deformation modelling was carried out using the MEPDG software v1.003 at the highest accuracy level. The nationally calibrate

Popular Abstract in Swedish SVENSK SAMMANFATTNING (SUMMARY IN SWEDISH) Hematopoes och leukemi Hematopoes är benämningen på den process vari alla blodceller genom hela livet kontinuerligt utvecklas i benmärgen, samt vid bildandet av lymfocyter även i lymfkörtlarna. Varje dygn bildas det ca 1012 nya celler i benmärgen för att ersätta uttjänta blodceller som dör och bryts ned. Ett litet antal stamcelWilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. In adult tissues WT1 expression is restricted to few organs, but various forms of cancers express high WT1 levels, suggesting an oncogenic potential

The various types of treatment of lymphedema are under discussion and there has been some controversy regarding liposuction for lymphedema. Although it is clear that conservative therapies such as complex decongestive therapy (CDT) and controlled compression therapy (CCT) should be tried in the first instance, options for the treatment of late-stage lymphedema that is not responding to such treatm

In this paper we argue that the emergence of the dominant model of university organization, which is characterized by a large agglomeration of many (often loosely affiliated) small research groups, might have an economic explanation that relates to the features of the scientific production process. In particular, we argue that there are decreasing returns to scale on the level of the individual re

Lärande sker i sociala sammanhang. Genom nätet är klassrummet idag globalt. Tusentals universitet, skolor och lärare i världen delar idag med sig av kursmaterial, föreläsningar, experiment, reportage och bilder så att andra kan återanvända materialet i sin undervisning.

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma