Celiaki som modell för autoimmun sjukdom. Transglutaminas har nyckelroll--stressreaktion sätter fart på ond cirkel
The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if
