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Despite the rich societal multilingualism of the United States, the ideological construction of English dominance continues to cast a shadow over other languages. Among the mechanisms that contribute to this state of affairs (e.g. educational policy and conservative language activism), visual language use in public spaces plays a salient role. A growing body of linguistic landscape research highli

AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function. METHODS: This Phase 2, placebo-controlled, dose-escalation clinical trial, which was randomized through a central office, was performed in 47 GADA-positive type 2 diabe

BACKGROUND: We have previously shown that a myocardial topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of different TNP levels between -50 and -150 mmHg on microvascular flow in normal and ischemic myocardium. MATER

The aim of the present study was to examine parity and age at first childbirth, in relation to the risk of specific breast cancer subgroups. A prospective cohort, The Malmö Diet and Cancer Study, including 17,035 women were followed with linkage to Swedish Cancer Registry until December 31, 2004. A total of 622 incident breast cancers were diagnosed during follow-up and were evaluated regarding in

Gastrointestinal (GI) complications are serious consequences of cardiac surgery. The aim of this study was to develop, evaluate and validate a new risk score model for GI complications after cardiac surgery. The risk score model, named gastrointestinal complication score (GICS), was developed using prospectively collected data from 5593 patients who underwent 5636 cardiac surgical procedures betwe

T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draini

In human skin, two main populations of dendritic cells (DC) can be discriminated: dermal DC (DDC) and epidermal Langerhans cells (LC). Although extensively studied, most of the knowledge about DDC and LC phenotype and function is obtained from studying DDC and LC cultured in vitro or DDC and LC migrated from skin explants. These studies have left the exact relationship between steady-state human L

OBJECTIVE: To compare the performance of the Cook Sydney IVF (SIVF) embryo transfer (ET) catheter and the Edwards-Wallace (EW) ET catheter. DESIGN: Prospective randomized controlled clinical trial with an intention-to-treat analysis. SETTING: Two-center study. PATIENT(S): Four hundred consecutive women <40 years undergoing ET with two fresh embryos. INTERVENTION(S): Women were randomly allocated t

Summary. The haemophilia literature increasingly contains reports describing the use of bypassing agent prophylaxis (BAP) in patients with severe haemophilia A and inhibitors. However, it is difficult to interpret and compare the results and draw conclusions about treatment efficacy because of small patient numbers and a lack of standardization among BAP studies. This article presents consensus re

Testing is used to ensure production of high quality integrated circuits. High test quality implies the application of high quality test data; however, technology development has led to a need to increase test data volumes to ensure high test quality. The problem is that the high test data volume leads to long test application times and high automatic test equipment memory requirement. For a modul

We study experimentally how to control and improve phase matching of high-order harmonic generation. We use a birefringent lens and a birefringent compensator to obtain a fundamental laser pulse (150 fs, 800 nm, similar to 4 mJ) With two foci Separated by 6.2 mm along the propagation axis and with a controllable phase delay between the polarizations along the optic axes of the birefringent optical

beta-Microseminoprotein (MSP), a 10kDa protein in human seminal plasma, binds human cysteine-rich secretory protein-3 (CRISP-3) with high affinity. CRISP-3 is a member of the family of CRISPs, which are widespread among animals. In this work we show that human as well as porcine MSP binds catrin, latisemin, pseudecin, and triflin, which are CRISPs present in the venoms of the snakes Crotalus atrox

In patients with severe haemophilia, spontaneous bleeding into joints initiates a sequence of events culminating in disabling arthropathy. Early evidence from Sweden suggested that clotting factor prophylaxis improved patient outcomes. Recent randomized, controlled trials comparing prophylaxis with on-demand treatment have definitively shown that prophylaxis reduces bleeding and improves joint out

BACKGROUND: Hazardous alcohol use is associated with an increased risk for development of a substance use disorder, leading to negative outcomes in psychiatric patients. AIMS: In order to investigate whether psychiatric outpatients' hazardous alcohol consumption could be reduced by way of a brief intervention by telephone. METHOD: Non-psychotic psychiatric outpatients, n = 1,670, completed a self-

Debate still surrounds which level of analysis (individual vs. contextual) is most appropriate to investigate the effects of social capital on health. Applying multilevel ecometric analyses to British Household Panel Survey data, we estimated fixed and random effects between five individual-, household- and small area-level social capital indicators and general health. We further compared the vari