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Ibrutinib, a Bruton’s tyrosine kinase inhibitor is approved for relapsed/refractory and del(17p)/TP53 mutated chronic lymphocytic leukemia. Discrepancies between clinical trials and routine healthcare are commonly observed in oncology. Herein we report real-world results for 95 poor prognosis Swedish patients treated with ibrutinib in a compassionate use program. Ninety-five consecutive patients (

Purpose: Survival after cancer has increased, and the question of risks in later pregnancies has become important. A previous malignancy may affect pregnancy outcome. Methods: Comparison of women with malignant disease before pregnancy with all other women giving birth during 1994-2011. Data were obtained by linkage between Swedish national health registers. Subfertility, evaluated as time to preg

A β-decay study of Cu77 has been performed at the ISOLDE mass separator with the aim to deduce its β-decay properties and to obtain spectroscopic information on Zn77. Neutron-rich copper isotopes were produced by means of proton- or neutron-induced fission reactions on U238. After the production, Cu77 was selectively laser ionized, mass separated, and sent to different detection systems where β-γ

The break-up of the 18.2 MeV state in 11Be was studied in a 11Li β-decay experiment. We report here on the study of the dominating breakup channels involving na6He or 3n2α in the final state, with special emphasis dedicated in this contribution to the three-particle channel. The two emitted charged particles were detected in coincidence using a highly segmented experimental set-up. The observed ex

The 9Li + 2H reaction has been investigated at 2.36 MeV/u at the REX-ISOLDE facility. In this Letter we focus on the 10Li + p channel which potentially holds spectroscopic information on the unbound nucleus 10Li. The experimental excitation energy spectrum and angular distribution are compared with CCBA calculations. These calculations clearly support the existence of a low-lying (s) virtual state

The β-delayed triple-α particle decay of 12B has been measured with a setup that favours coincidence detection. A broad state in 12C, previously reported around 10 MeV, has been seen and its properties determined through R-matrix analysis of the excitation spectrum. The spin and parity are 0+. Interference between this state and the Hoyle state at 7.654 MeV has a marked influence on the spectrum.

The neutron-rich nuclei 72Ni and 72Cu have been produced in the proton-induced fission of 238U at the LISOL and ISOLDE facilities of Louvain-La-Neuve and CERN. Partial β-decay schemes are presented, giving some information about the nuclear structure of their daughter nuclei 72Cu and 72Zn. The lifetime of 72Cu was determined to be T1/2 = 6.63(3) s, in line with previous measurements. No β-decaying

We report here on the recent β-decay studies of the A = 9 isobar made at ISOLDE/CERN. Mirror beta transitions in the A=9 chain are compared and a large asymmetry factor is deduced for the transitions to high excitation energy in 9Be (11.8 MeV) arid 9B (12.2 MeV) fed in the β-decay of 9Li and 9C respectively. It is shown that the asymmetry is not due to experimental problems or differences in the m

We discuss the importance of the spectroscopic properties of the resonances of 12C just above the 3α-threshold, and review the existing experimental information of this region with emphasis on O+ and 2+ states. A new experimental approach for studying the β-decays of 12B and 12N is presented based on techniques developed in the context of Radioactive beam (rare isotope) physics. Finally preliminar

The γ-ray spectrum following β-decay of 11Li has been remeasured at the ISOLDE facility at CERN. Two new transitions were observed through the use of large Ge-detectors. Most γ-decays will follow β-delayed neutron emission. Information on the energy of the neutron is derived from analysis of the γ line-shape and used to construct a partial decay scheme for 11Li. Lifetime values for the 1- and 2- l

The particle unbound nucleus 10Li has been investigated at the newly constructed post-accelerator REX-ISOLDE at CERN via the 9Li+d →+ 10Li+p reaction at 2.36 MeV/u. We present here the preliminary analysis of our first data from REX-ISOLDE.

Nature-based rehabilitation (NBR) has convincing support in research, yet the underlying mechanisms are not fully understood. The present study sought to increase understanding of the role of soundscapes in NBR, an aspect paid little attention thus far. Transcribed interviews with 59 patients suffering from stress-related mental disorders and undergoing a 12-week therapy programme in the rehabilit

Information on gross β-decay properties of neutron-rich noble gas isotopes 49,50Ar was obtained at the PSB-ISOLDE facility at CERN using isobaric selectivity achieved by the combination of a plasma ion source with a cooled transfer line and subsequent mass separation. A doubly charged beam was used in the case of 49Ar to suppress the corresponding multicharged background from heavier noble gas fis

Yields of He, Ne, Ar, Kr and Xe isotopic chains were measured from UCx/graphite and ThCx/graphite targets at the PSB-ISOLDE facility at CERN using isobaric selectivity achieved by the combination of a plasma-discharge ion source with a water-cooled transfer line. The delay times measured for a UCx/graphite target allow for an extrapolation to the expected yields of very neutron-rich noble gas isot

At REX-ISOLDE at ISOLDE/CERN radioactive ions are post accelerated with a 10 meters linac for experiments in nuclear-, astro- and solid state physics. For the efficient acceleration to energies between 0.8 and 2.3 MeV/u the principles of charge breeding of radioactive ions by an electron beam source was introduced at REX. The linac in its current stage consists of a 4-rod RFQ, a 20-gap IH drift tu

Event-based sensing and communication holds the promise of lower resource utilization and/or better performance for remote state estimation applications found in e.g. networked control systems. Recently, stochastic event-triggering rules have been proposed as a means to avoid the complexity of the problem that normally arises in event-based estimator design. By using a scaled Gaussian function in

Beta delayed charged particles from 14Be have been measured and give an upper limit on beta delayed alpha particles of B(βα)<6.7×10-5 and a tentative branching ratio on beta delayed tritons of 7.5×10-5

The radioactive beam experiment (REX-ISOLDE) is now in the commissioning phase. REX-ISOLDE is a pilot experiment for testing a new concept of post acceleration at ISOLDE/CERN. The concept of REX-ISOLDE using a Penning trap-EBIS combination as a charge breeder and a compact LINAC for post acceleration requires detailed tests of all components in order to get a high efficiency. First measurements wi